当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS期刊下所有文献 > Target site bacterial killing of cefpirome and fosfomycin in critically ill patients.

Target site bacterial killing of cefpirome and fosfomycin in critically ill patients.

Abstract：

:We employed an in-vivo pharmacokinetic/in-vitro pharmacodynamic method to simulate bacterial killing in plasma and the interstitium of skeletal muscle tissue after intravenous administration of 2 g of cefpirome and 8 g of fosfomycin alone and in combination to patients with sepsis. Interstitial antimicrobial concentrations were determined by use of in-vivo microdialysis. CFU/ml of Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (clinical isolate) decreased by approximately 2log(10) for plasma and muscle tissue 6 h after cefpirome and fosfomycin administration compared with the baseline, respectively. The simulation of plasma and tissue pharmacokinetics for the combined administration of these antibiotics resulted in complete eradication of S. aureus within 5 h after drug exposure. No bacterial re-growth occurred in any of the simulations within 6 h. The in-vitro simulation of in-vivo plasma and tissue pharmacokinetics of cefpirome and fosfomycin has shown that both antimicrobial agents kill S. aureus and P. aeruginosa strains effectively after single dose administration. This effect was most pronounced by the combined use of these antimicrobial agents. Therefore, this data corroborates antimicrobial strategies of simultaneous administration of cefpirome and fosfomycin in patients with severe soft tissue infection.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Zeitlinger MA,Marsik C,Georgopoulos A,Müller M,Heinz G,Joukhadar C

doi

10.1016/s0924-8579(03)00047-5

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

562-7

issue

6

eissn

0924-8579

issn

1872-7913

pii

S0924857903000475

journal_volume

21

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS文献大全
  • Molecular identification of aminoglycoside-modifying enzymes in clinical isolates of Escherichia coli resistant to amoxicillin/clavulanic acid isolated in Spain.

    abstract：:The activity of eight aminoglycosides (amikacin, apramycin, arbekacin, gentamicin, kanamycin, neomycin, netilmicin and tobramycin) against a collection of 257 amoxicillin/clavulanic acid (AMC)-resistant Escherichia coli isolates was determined by microdilution. Aminoglycoside resistance rates, the prevalence of aminog...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijantimicag.2015.03.008

    authors： Fernández-Martínez M,Miró E,Ortega A,Bou G,González-López JJ,Oliver A,Pascual A,Cercenado E,Oteo J,Martínez-Martínez L,Navarro F,Spanish Network for the Research in Infectious Diseases (REIPI).

    更新日期：2015-08-01 00:00:00

  • Chemical and biological metal nanoparticles as antimycobacterial agents: A comparative study.

    abstract：:Resistance among mycobacteria leading to multidrug-resistant and extensively drug-resistant tuberculosis is a major threat. However, nanotechnology has provided new insights in drug delivery and medicine development. This is the first comparative report to determine the activity of chemically and biologically synthesi...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2015.03.014

    authors： Singh R,Nawale LU,Arkile M,Shedbalkar UU,Wadhwani SA,Sarkar D,Chopade BA

    更新日期：2015-08-01 00:00:00

  • Modulation of mgrB gene expression as a source of colistin resistance in Klebsiella oxytoca.

    abstract：:Gene modifications in the PmrAB and PhoPQ two-component regulatory systems, as well as inactivation of the mgrB gene, are known to be causes of colistin resistance in Klebsiella pneumoniae. The objective of this study was to characterise the mechanism involved in colistin resistance in a Klebsiella oxytoca isolate. A ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2015.02.015

    authors： Jayol A,Poirel L,Villegas MV,Nordmann P

    更新日期：2015-07-01 00:00:00

  • Forecasting carbapenem resistance from antimicrobial consumption surveillance: Lessons learnt from an OXA-48-producing Klebsiella pneumoniae outbreak in a West London renal unit.

    abstract：:This study aimed to forecast the incidence rate of carbapenem resistance and to assess the impact of an antimicrobial stewardship intervention using routine antimicrobial consumption surveillance data. Following an outbreak of OXA-48-producing Klebsiella pneumoniae (January 2008-April 2010) in a renal cohort in London...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2015.03.005

    authors： Gharbi M,Moore LS,Gilchrist M,Thomas CP,Bamford K,Brannigan ET,Holmes AH

    更新日期：2015-08-01 00:00:00

  • Infective endocarditis caused by USA300 methicillin-resistant Staphylococcus aureus (MRSA).

    abstract：:We report seven cases of infective endocarditis caused by USA300 methicillin-resistant Staphylococcus aureus (MRSA) at an urban, tertiary care, academic institution. Five strains were community associated and two were healthcare associated. All patients were injection drug users. Staphylococcus aureus isolates were ch...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2007.02.007

    authors： Haque NZ,Davis SL,Manierski CL,Vager D,Donabedian SM,Perri MB,Sabbagh R,Cheema F,Zervos MJ

    更新日期：2007-07-01 00:00:00

  • Rational diagnostic steps in acute pyelonephritis with special reference to ultrasonography and computed tomography scan.

    abstract：:Depending on the severity of the clinical syndrome, acute pyelonephritis may require more extensive imaging diagnostics. In the uncomplicated form of the disease, ultrasonography does not appear to be absolutely necessary. In clinically severe cases, however, which fail to respond to antibiotic therapy, ultrasound is ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(99)00026-6

    authors： Weidner W,Ludwig M,Weimar B,Rau W

    更新日期：1999-05-01 00:00:00

  • Lipid-based amphotericin B: a review of the last 10 years of use.

    abstract：:The last decade has been remarkable for the dramatic increase in the prevalence of serious fungal infections in patients with haematological disorders and neutropenic cancer patients. The mortality rate of deep-seated infection has been in excess of 90% and there is no doubt that this is one of the greatest challenges...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/s0924-8579(00)00341-1

    authors： Hann IM,Prentice HG

    更新日期：2001-03-01 00:00:00

  • Ridinilazole: a novel therapy for Clostridium difficile infection.

    abstract：:Clostridium difficile infection (CDI) is the leading cause of infectious healthcare-associated diarrhoea. Recurrent CDI increases disease morbidity and mortality, posing a high burden to patients and a growing economic burden to the healthcare system. Thus, there exists a significant unmet and increasing medical need ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2016.04.026

    authors： Vickers RJ,Tillotson G,Goldstein EJ,Citron DM,Garey KW,Wilcox MH

    更新日期：2016-08-01 00:00:00

  • Why new antibiotics are not obviously useful now.

    abstract：:For several years, the threat of antibiotic resistance and its health cost has dramatically risen and various alarming figures have been proposed to illustrate the mortality due to antibiotic resistance. However, predictions concerning different living beings are doomed to failure, as theorised in Alice's 'living croq...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2016.11.015

    authors： Dubourg G,Abat C,Raoult D

    更新日期：2017-05-01 00:00:00

  • Variability of piperacillin concentrations in relation to tazobactam concentrations in critically ill patients.

    abstract：:Therapeutic drug monitoring for critically ill patients receiving piperacillin/tazobactam is described as a useful tool. However, the minimum inhibitory concentration of piperacillin depends on a sufficiently high concentration of tazobactam in case of β-lactamase-producing strains. Therefore, the relationship between...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.06.013

    authors： Zander J,Döbbeler G,Nagel D,Scharf C,Huseyn-Zada M,Jung J,Frey L,Vogeser M,Zoller M

    更新日期：2016-10-01 00:00:00

  • In vitro activity of older and newer fluoroquinolones against efflux-mediated high-level ciprofloxacin-resistant Streptococcus pneumoniae.

    abstract：:The effect of high-level efflux activity on the MICs of fluoroquinolones against Streptococcus pneumoniae in the absence of topoisomerase mutations leading to fluoroquinolones resistance was investigated. A S. pneumoniae ATCC 46619-derived strain with high-level efflux activity was obtained (SP-25A). Both the parent a...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.01.012

    authors： Daporta MT,Muñoz Bellido JL,Guirao GY,Hernández MS,García-Rodríguez JA

    更新日期：2004-08-01 00:00:00

  • Antimicrobial growth promoter use in livestock: a requirement to understand their modes of action to develop effective alternatives.

    abstract：:Antimicrobial agents (AMAs) have been used in agriculture since the 1950s as growth-promoting agents [antimicrobial growth promoters (AGPs)]. They have provided benefits to the agricultural industry by increasing production efficiencies and maximising livestock health, yet the potential risks surrounding resistance to...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2016.08.006

    authors： Brown K,Uwiera RRE,Kalmokoff ML,Brooks SPJ,Inglis GD

    更新日期：2017-01-01 00:00:00

  • Role of gemifloxacin in the management of community-acquired lower respiratory tract infections.

    abstract：:Respiratory tract infections (RTIs) form a substantial clinical and financial burden, with the increasing complication of antimicrobial resistance. This resistance may compromise the use of many empirically prescribed antimicrobials. The new respiratory fluoroquinolones have been developed to overcome this burgeoning ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2007.12.003

    authors： Blondeau JM,Tillotson G

    更新日期：2008-04-01 00:00:00

  • What is the relevance of fosfomycin pharmacokinetics in the treatment of serious infections in critically ill patients? A systematic review.

    abstract：:As treatment options for critically ill patients with multidrug-resistant bacteria diminish, older antibiotics such as fosfomycin are being investigated for use as last-resort drugs. Fosfomycin is a broad-spectrum antibiotic with activity both against Gram-positive and Gram-negative bacteria. The aim of this review wa...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2013.05.018

    authors： Parker S,Lipman J,Koulenti D,Dimopoulos G,Roberts JA

    更新日期：2013-10-01 00:00:00

  • Emergence of a cefepime- and cefpirome-resistant Citrobacter freundii clinical isolate harbouring a novel chromosomally encoded AmpC beta-lactamase, CMY-37.

    abstract：:Citrobacter freundii strain 4306 was isolated from a urine specimen of a patient in March 2006 in Palestine. This strain showed a unique multidrug resistance phenotype, as it was resistant both to 7-alpha-methoxy- and oxyimino-cephalosporins, including cefepime, cefpirome and monobactams, in addition to quinolones, st...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2008.04.019

    authors： Ahmed AM,Shimamoto T

    更新日期：2008-09-01 00:00:00

  • Investigations into the in vitro antimicrobial activity and mode of action of the phenazine antibiotic D-alanylgriseoluteic acid.

    abstract：:D-Alanylgriseoluteic acid (AGA) is a potent antimicrobial phenazine compound produced by Pantoea agglomerans (Erwinia herbicola) Eh1087. Susceptibility tests against a range of microbes indicated that AGA had a broad spectrum of antimicrobial activity and was particularly active against Gram-positive pathogens. Compar...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.08.028

    authors： Giddens SR,Bean DC

    更新日期：2007-01-01 00:00:00

  • Activity of linezolid-containing regimens against multidrug-resistant tuberculosis in mice.

    abstract：:The objective of the present study was to compare the activities of regimens containing linezolid (LZD) with those not containing LZD against Mycobacterium tuberculosis infection in mice. The three regimens excluding LZD selected in this study are often used in practice against multidrug-resistant tuberculosis (MDR-TB...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2013.10.010

    authors： Zhao W,Guo Z,Zheng M,Zhang J,Wang B,Li P,Fu L,Liu S

    更新日期：2014-02-01 00:00:00

  • Resistance to macrolides by ribosomal mutation in clinical isolates of Turicella otitidis.

    abstract：:The genetic basis of erythromycin resistance in Turicella otitidis, a coryneform bacteria associated with otitis, was studied in five macrolide-resistant clinical isolates. Macrolide resistance genes were searched for by polymerase chain reaction (PCR). Genes for domain V of 23S rRNA (rrl) as well as rplD (L4 protein)...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2009.03.023

    authors： Boumghar-Bourtchai L,Chardon H,Malbruny B,Mezghani S,Leclercq R,Dhalluin A

    更新日期：2009-09-01 00:00:00

  • In vitro activity of KRM-1648, either singly or in combination with ofloxacin, against Mycobacterium ulcerans.

    abstract：:The antimicrobial effect of a benzoxazinorifamycin, KRM-1648, either alone or in combination with ofloxacin, was evaluated in vitro against two type strains and six clinical isolates of Mycobacterium ulcerans. Growth of M. ulcerans was measured by plate counts and the BACTEC radiometric method. The minimal inhibitory ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(00)00306-x

    authors： Dhople AM

    更新日期：2001-01-01 00:00:00

  • Antibiotic prophylaxis in head and neck oncologic surgery: the role of gram-negative coverage.

    abstract：:Many studies have elucidated the risk factors associated with peri-operative infection following head and neck cancer surgery (HNS), the implications of infection for total treatment cost, and the clinical benefits of successful antimicrobial prophylaxis. The most appropriate antibiotic use is achieved by focusing on ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/s0924-8579(99)00088-6

    authors： Callender DL

    更新日期：1999-08-01 00:00:00

  • Effect of administration of diethylcarbamazine on experimental bacterial and fungal infections in mice.

    abstract：:Other researchers have found that diethylcarbamazine (DEC) is effective treatment for filariasis despite a lack of demonstrated in vitro antifilarial activity. The results of our previous investigations using feline and murine leukemia virus models encouraged us to investigate the use of DEC with other infections. In ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/0924-8579(92)90037-r

    authors： Kitchen LW,Ross JA,Hernandez JE,Zarraga AL,Mather FJ

    更新日期：1992-09-01 00:00:00

  • Cellulitis syndromes: an update.

    abstract：:Cellulitis is a commonly seen clinical syndrome that is most often associated with beta-haemolytic streptococci and Staphylococcus aureus. Several medical conditions and a variety of procedures can predispose to the development of cellulitis by a common mechanism: venous and lymphatic compromise. The precise pathophys...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(99)00169-7

    authors： Baddour LM

    更新日期：2000-03-01 00:00:00

  • Ciprofloxacin versus chloramphenicol in the treatment of salmonella infection.

    abstract：:Strains of Salmonella typhi resistant to chloramphenicol and ampicillin have been isolated in several countries. This study compares treatment of Salmonella infection using ciprofloxacin (500 mg twice daily) for 10 days with chloramphenicol (50 mg/kg per day divided into four doses) for 14 days. The pathogen eradicati...

    journal_title：International journal of antimicrobial agents

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0924-8579(00)00262-4

    authors： Liberti A,Loiacono L

    更新日期：2000-11-01 00:00:00

  • Susceptibility of contemporary isolates to fosfomycin: a systematic review of the literature.

    abstract：:The aim of this review was to evaluate the susceptibility of contemporary Gram-positive and Gram-negative bacteria to fosfomycin. PubMed and Scopus databases were systematically searched to identify studies published in print or electronically from January 2010 until June 2015. In total, 84 studies were selected. Susc...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2016.02.001

    authors： Vardakas KZ,Legakis NJ,Triarides N,Falagas ME

    更新日期：2016-04-01 00:00:00

  • Over-the-counter acquisition of antibiotics in the Maltese general population.

    abstract：:Few studies have studied the frequency of over-the-counter acquisition of antibiotics in western countries. In order to provide an insight into these practices in Malta, attitudes towards antibiotic use in the general public were researched through a structured interview. Nineteen percent admitted that they took antib...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(02)00194-2

    authors： Borg MA,Scicluna EA

    更新日期：2002-10-01 00:00:00

  • Levofloxacin versus ceftriaxone plus clarithromycin in the treatment of adults with community-acquired pneumonia requiring hospitalization.

    abstract：:Consecutive adult patients admitted to the hospital with community-acquired pneumonia from January 2000 to September 2003 were included in this prospective observational cohort study. A total of 459 patients, 259 treated with levofloxacin in single drug therapy at a dose of 500 mg once a day and 209 with the combinati...

    journal_title：International journal of antimicrobial agents

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ijantimicag.2004.07.013

    authors： Querol-Ribelles JM,Tenías JM,Querol-Borrás JM,Labrador T,Nieto A,González-Granda D,Martínez I

    更新日期：2005-01-01 00:00:00

  • Fosfomycin trometamol and N-acetyl-L-cysteine as combined oral therapy of difficult-to-treat chronic bacterial prostatitis: Results of a pilot study.

    abstract：:This paper presents the results of a pilot study of difficult-to-treat patients (exhibiting several previous treatment failures or detection of extended-spectrum beta-lactamase [ESBL] strains) with chronic bacterial prostatitis (CBP) who underwent treatment with fosfomycin trometamol (FT) and N-acetyl-L-cysteine (NAC)...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.105935

    authors： Cai T,Tamanini I,Mattevi D,Verze P,Palmieri A,Malossini G,Mirone V,Novelli A,Tascini C,Johansen TEB

    更新日期：2020-07-01 00:00:00

  • Direct confocal microscopy studies of the bacterial colonization in vitro of a silver-coated heart valve sewing cuff.

    abstract：:The antimicrobial coating of prosthetic heart valve sewing cuffs has been considered a potentially effective method for preventing prosthetic valve endocarditis. Although traditional in vitro bacterial adherence studies are often useful as screening tools, they can be inadequate in examining the antiinfective efficacy...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(99)00120-x

    authors： Cook G,Costerton JW,Darouiche RO

    更新日期：2000-01-01 00:00:00

  • Moxifloxacin is non-inferior to combination therapy with ceftriaxone plus metronidazole in patients with community-origin complicated intra-abdominal infections.

    abstract：:Management of community-origin complicated intra-abdominal infections (cIAIs) requires surgical intervention and antimicrobial therapy. This multinational, randomised, double-blind clinical trial carried out in Asia compared the efficacy and safety of moxifloxacin monotherapy and ceftriaxone/metronidazole combination ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ijantimicag.2009.06.022

    authors： Solomkin J,Zhao YP,Ma EL,Chen MJ,Hampel B,DRAGON Study Team.

    更新日期：2009-11-01 00:00:00

  • Evaluation of the in vitro activities of ceftobiprole and comparators in staphylococcal colony or microtitre plate biofilm assays.

    abstract：:The aim of this study was to evaluate the in vitro efficacy of ceftobiprole and comparator antibiotics, either alone or in combination, in staphylococcal MBEC™ (minimum biofilm eradication concentration) and colony biofilm assays at dilutions of the maximum free-drug plasma concentration attained during clinical use (...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2013.09.013

    authors： Abbanat D,Shang W,Amsler K,Santoro C,Baum E,Crespo-Carbone S,Lynch AS

    更新日期：2014-01-01 00:00:00