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Treatment of murine Fusarium verticillioides infection with liposomal amphotericin B plus terbinafine.

Abstract：

:Using a murine model of disseminated infection by Fusarium verticillioides, the efficacy of liposomal amphotericin (L-AmB) B at 10mg/kg body weight once daily and terbinafine (TRB) at 150 mg/kg body weight twice daily, alone and in combination, was evaluated. The combination of L-AmB with TRB was the only treatment able to prolong survival and to reduce fungal loads in the spleen and kidneys of mice infected with either strain of F. verticillioides used. The results suggest that this combination may have a role in the treatment of F. verticillioides infection.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Ruíz-Cendoya M,Pastor FJ,Capilla J,Guarro J

doi

10.1016/j.ijantimicag.2010.08.008

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

58-61

issue

1

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(10)00367-5

journal_volume

37

pub_type

杂志文章

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