当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS期刊下所有文献 > A broad-spectrum antifungal from the marine sponge Hyrtios erecta.

A broad-spectrum antifungal from the marine sponge Hyrtios erecta.

Abstract：

:Spongistatin 1, a macrocyclic lactone polyether from the marine sponge Hyrtios erecta, was fungicidal for a variety of opportunistic yeasts and filamentous fungi, including strains resistant to amphotericin B, ketoconazole and flucytosine. In broth macrodilution assays, MICs ranged from 0.195 to 12.5 microg/ml, and minimum fungicidal concentrations ranged from 3.12 to 25 microg/ml. Initial disk diffusion screens with six related macrocyclic lactone polyethers from H. erecta and Spirastrella spinispirulifera, revealed that these polyethers were also antifungal. The fungicidal activity of spongistatin 1 was confirmed in killing kinetics studies, where killing of Candida albicans and Cryptococcus neoformans occurred within 6 and 12 h, respectively. During the killing kinetics experiments, non-treated C. albicans maintained the yeast morphology. However, elongated forms resembling germ tubes were the predominant morphologic form in spongistatin 1-treated C. albicans cultures. The spongistatins show promise as potential antifungal agents and as probes to study fungal morphogenesis and nuclear division.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Pettit RK,McAllister SC,Pettit GR,Herald CL,Johnson JM,Cichacz ZA

doi

10.1016/s0924-8579(97)00044-7

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

147-52

issue

3

eissn

0924-8579

issn

1872-7913

pii

S0924857997000447

journal_volume

9

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS文献大全
  • Macrolides: pharmacokinetics and pharmacodynamics.

    abstract：:Three pharmacokinetic/pharmacodynamic parameters--(i) the peak concentration to the minimum inhibitory concentration ratio (C(max)/MIC); (ii) the area under the concentration-time curve to MIC ratio (AUC(24h)/MIC); and (iii) the time the concentration exceeds the MIC (T>MIC)--are important predictors of the clinical e...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/s0924-8579(01)00406-x

    authors： Van Bambeke F,Tulkens PM

    更新日期：2001-01-01 00:00:00

  • Cellulitis syndromes: an update.

    abstract：:Cellulitis is a commonly seen clinical syndrome that is most often associated with beta-haemolytic streptococci and Staphylococcus aureus. Several medical conditions and a variety of procedures can predispose to the development of cellulitis by a common mechanism: venous and lymphatic compromise. The precise pathophys...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(99)00169-7

    authors： Baddour LM

    更新日期：2000-03-01 00:00:00

  • Vancomycin resistance in Enterococcus faecium isolated from Danish chicken meat is located on a pVEF4-like plasmid persisting in poultry for 18 years.

    abstract：:The occurrence of vancomycin-resistant Enterococcus faecium (VREfm) in food is relevant to public health as foodborne VREfm may colonize the gut of consumers and transfer vancomycin resistance genes to the indigenous gut microbiota. Therefore, we determined occurrence and elucidated genetic traits of VREfm in Danish r...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.03.019

    authors： Leinweber H,Alotaibi SMI,Overballe-Petersen S,Hansen F,Hasman H,Bortolaia V,Hammerum AM,Ingmer H

    更新日期：2018-08-01 00:00:00

  • Combined treatment of Pseudomonas aeruginosa biofilm with lactoferrin and xylitol inhibits the ability of bacteria to respond to damage resulting from lactoferrin iron chelation.

    abstract：:With an ageing and ever more obese population, chronic wounds such as diabetic ulcers, pressure ulcers and venous leg ulcers are an increasingly relevant medical concern. Identification of bacterial biofilm contamination as a major contributor to non-healing wounds demands biofilm-targeted strategies to manage chronic...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2010.12.019

    authors： Ammons MC,Ward LS,Dowd S,James GA

    更新日期：2011-04-01 00:00:00

  • Antifungal activities of azole agents against the Malassezia species.

    abstract：:In this paper, we identified 95 Malassezia isolates by morphological and biochemical criteria and assessed the in vitro activity of fluconazole, itraconazole, ketoconazole and voriconazole by broth microdilution against these species using slightly modified Leeming-Notman medium. The Malassezia isolates were identifie...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.09.016

    authors： Miranda KC,de Araujo CR,Costa CR,Passos XS,de Fátima Lisboa Fernandes O,do Rosário Rodrigues Silva M

    更新日期：2007-03-01 00:00:00

  • Global coronavirus disease 2019: What has daily cumulative index taught us?

    abstract：:In addition to the absolute case number, a rapid increase in the number of COVID-19 cases within a short time results in insufficiency of healthcare systems and further negatively affects patient outcomes. This study was conducted to investigate the association between the outcomes of COVID-19 patients and daily cumul...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.106001

    authors： Lai CC,Wang CY,Wang YH,Hsueh PR

    更新日期：2020-06-01 00:00:00

  • A cohort study of treatment-experienced HIV-1-infected patients treated with raltegravir: factors associated with virological response and mutations selected at failure.

    abstract：:This study aimed to identify factors associated with virological response (VR) to raltegravir (RAL)-containing regimens in 468 treatment-experienced but integrase inhibitor-naive HIV-1 patients receiving a RAL-containing regimen. VR was defined at Month 6 (M6) as HIV-1 RNA viral load (VL) <50 copies/mL. The impacts on...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2013.02.016

    authors： Marcelin AG,Delaugerre C,Beaudoux C,Descamps D,Morand-Joubert L,Amiel C,Schneider V,Ferre V,Izopet J,Si-Mohamed A,Maillard A,Henquell C,Desbois D,Lazrek M,Signori-Schmuck A,Rogez S,Yerly S,Trabaud MA,Plantier JC,Fou

    更新日期：2013-07-01 00:00:00

  • Drug combinations with amoxycillin reduce selection of clarithromycin resistance during Helicobacter pylori eradication therapy.

    abstract：:This study investigated the relationship between the drug combinations of the eradication regimens and the prevalence of acquired resistance to clarithromycin. Of 540 patients treated with anti-Helicobacter pylori regimens containing clarithromycin, 55 patients (31 males, mean age, 45.6 years) with failed eradication ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(01)00456-3

    authors： Murakami K,Fujioka T,Okimoto T,Sato R,Kodama M,Nasu M

    更新日期：2002-01-01 00:00:00

  • Role of piperacillin/tazobactam as a carbapenem-sparing antibiotic for treatment of acute pyelonephritis due to extended-spectrum β-lactamase-producing Escherichia coli.

    abstract：:Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) is a frequent cause of acute pyelonephritis (APN), requiring carbapenem therapy. However, alternatives to carbapenems are needed due to the emergence of carbapenemase-producing micro-organisms. The purpose of this study was to compare the clinical effi...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.12.017

    authors： Yoon YK,Kim JH,Sohn JW,Yang KS,Kim MJ

    更新日期：2017-04-01 00:00:00

  • Review and mapping of carbapenem-resistant Enterobacteriaceae in Africa: Using diverse data to inform surveillance gaps.

    abstract：:Carbapenem-resistant Enterobacteriaceae (CRE) are among the most difficult to treat emerging multidrug-resistant organisms. Major limitations exist in surveillance needed to address CRE, particularly in areas with inadequate resources. We utilised optimised strategies to search for data on carbapenem susceptibility of...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2018.05.019

    authors： Mitgang EA,Hartley DM,Malchione MD,Koch M,Goodman JL

    更新日期：2018-09-01 00:00:00

  • In vitro prevention of Pseudomonas aeruginosa early biofilm formation with antibiotics used in cystic fibrosis patients.

    abstract：:The ability of antibiotics used in bronchopulmonary infections in cystic fibrosis (CF) patients to prevent Pseudomonas aeruginosa early biofilm formation was studied using a biofilm microtitre assay with 57 non-mucoid P. aeruginosa isolates (44 first colonisers and 13 recovered during the initial intermittent colonisa...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2012.04.006

    authors： Fernández-Olmos A,García-Castillo M,Maiz L,Lamas A,Baquero F,Cantón R

    更新日期：2012-08-01 00:00:00

  • Susceptibility and resistance genes to fluoroquinolones in methicillin-resistant Staphylococcus aureus isolated in 2002.

    abstract：:The activity of six fluoroquinolones (FQs) was determined against 100 methicillin-resistant Staphylococcus aureus (MRSA) isolated in 2002 along with mutations in the grlA and gyrA genes and in the norA promoter of these isolates. Of the isolates tested, 97% had mutations in grlA and gyrA. A single mutation in grlA and...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.11.016

    authors： Noguchi N,Okihara T,Namiki Y,Kumaki Y,Yamanaka Y,Koyama M,Wakasugi K,Sasatsu M

    更新日期：2005-05-01 00:00:00

  • Sequences of a co-existing SXT element, a chromosomal integron (CI) and an IncA/C plasmid and their roles in multidrug resistance in a Vibrio cholerae O1 El Tor strain.

    abstract：:The ongoing seventh cholera pandemic is attributed to Vibrio cholerae O1 El Tor biotype strains. Although antibiotic therapy ameliorates symptoms in patients and reduces pathogen transfer to the environment, multidrug resistance remains a major clinical threat. An O1 El Tor strain isolated from a patient in 1998 was i...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.05.020

    authors： Wang R,Li J,Kan B

    更新日期：2016-09-01 00:00:00

  • Potency of DX-619, a novel des-F(6)-quinolone, in haematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.

    abstract：:In this study, the potency of DX-619, a novel des-fluoro(6)-quinolone agent, was compared with that of vancomycin (VCM) in a murine model of haematogenous bronchopneumonia infection caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate S. aureus (VISA). The minimum inhibitory concent...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.03.026

    authors： Yanagihara K,Seki M,Izumikawa K,Higashiyama Y,Miyazaki Y,Hirakata Y,Tomono K,Mizuta Y,Tsukamoto K,Kohno S

    更新日期：2006-09-01 00:00:00

  • Do antibacterial and antifungal combinations have better activity against clinically relevant fusarium species? in vitro synergism.

    abstract：:The aim of this study was to evaluate the susceptibility of 20 clinical isolates of Fusarium spp. to classic antifungals [amphotericin B (AmB), itraconazole (ITR), voriconazole (VRC) and caspofungin (CAS)] and to non-antifungal agents [amiodarone (AMD), doxycycline (DOX) and moxifloxacin (MFX)] by the broth microdilut...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.10.017

    authors： Venturini TP,Al-Hatmi AMS,Rossato L,Azevedo MI,Keller JT,Weiblen C,Santurio JM,Alves SH

    更新日期：2018-05-01 00:00:00

  • Pan-European resistance monitoring programmes encompassing food-borne bacteria and target pathogens of food-producing and companion animals.

    abstract：:Antimicrobial resistance is a concern both for animal and human health. Veterinary programmes monitoring resistance of animal and zoonotic pathogens are therefore essential. Various European countries have implemented national surveillance programmes, particularly for zoonotic and commensal bacteria, and the European ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2012.11.004

    authors： de Jong A,Thomas V,Klein U,Marion H,Moyaert H,Simjee S,Vallé M

    更新日期：2013-05-01 00:00:00

  • Antimicrobial resistance of Neisseria gonorrhoeae in Japan, 1993-2002: continuous increasing of ciprofloxacin-resistant isolates.

    abstract：:Susceptibility testing was conducted on 1357 isolates of Neisseria gonorrhoeae isolated from 1993 through 2002 in Japan to assess the antimicrobial resistance. Selected isolates were characterised by auxotype and analysis was done for mutations within the quinolone resistance-determining region (QRDR) in the gyrA and ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.02.005

    authors： Tanaka M,Nakayama H,Notomi T,Irie S,Tsunoda Y,Okadome A,Saika T,Kobayashi I

    更新日期：2004-09-01 00:00:00

  • Predictive value of nalidixic acid resistance for detecting salmonellae with decreased ciprofloxacin susceptibility.

    abstract：:Seventy-three Salmonella isolates classified as ciprofloxacin susceptible when using the criteria of the National Committee for Clinical Laboratory Standards were studied for nalidixic acid (NA) resistance. The aim of the study was to determine the predictive value of nalidixic acid resistance in screening for decreas...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2003.09.014

    authors： Albayrak F,Cokca F,Erdem B,Aysev AD

    更新日期：2004-04-01 00:00:00

  • Detection of amp C in Enterobacter cloacae in China.

    abstract：:PCR amplification of 55 strains of Enterobacter cloacae indicated 51 of them had amp C structural gene verified by DNA sequence and Southern blotting. All PCR products were cleaved into 666- and 328-bp fragments by Kpn1 restriction enzyme. Imipenem was the most potent inducer for mRNA expression of amp C gene and beta...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(01)00414-9

    authors： Zhang YL,Li JT,Zhao MW

    更新日期：2001-10-01 00:00:00

  • Antibiotic susceptibilities of livestock isolates of leptospira.

    abstract：:Leptospirosis is the most common zoonotic disease and is endemic worldwide. The antibiotic susceptibilities of Leptospira strains isolated from both humans and animals are poorly documented. This issue is particularly important for isolates from food-producing animals which are regularly exposed to antibiotic treatmen...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.12.024

    authors： Liegeon G,Delory T,Picardeau M

    更新日期：2018-05-01 00:00:00

  • Uncommon Detection of Mixed HCV Genotype Infections in Recently Infected Men Who Have Sex with Men.

    abstract：INTRODUCTION:Mixed hepatitis C virus (HCV) genotype (GT) infections are clinically important as different genotypes have varied sensitivities to direct-acting antivirals (DAAs). A high prevalence of mixed GT infections was observed in individuals who inject drugs and had multiple HCV exposures. The prevalence of mixed ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.06.001

    authors： Nguyen T,Delaugerre C,Valantin MA,Amiel C,Netzer E,L'Yavanc T,Ohayon M,Israel G,Valin N,Day N,Kreplak G,Pialoux G,Calvez V,Molina JM,Marcelin AG,Todesco E

    更新日期：2019-10-01 00:00:00

  • Azole resistance mechanisms in Aspergillus: update and recent advances.

    abstract：:Aspergillus fumigatus is the main causal agent of invasive aspergillosis (IA), however other species of the genus can also cause IA, such as Aspergillus flavus, Aspergillus terreus, Aspergillus niger and related cryptic species. This infectious disease mainly affects immunosuppressed patients and is linked to elevated...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2019.09.011

    authors： Pérez-Cantero A,López-Fernández L,Guarro J,Capilla J

    更新日期：2020-01-01 00:00:00

  • Disposition and intracellular activity of azithromycin in human THP-1 acute monocytes.

    abstract：:Uptake of [14C]-azithromycin into THP-1 human monocytes was determined at pH 7.4, 6.8 or 5.5 over 4-log antibiotic concentrations for 24 h under a number of conditions. Stimulation of cells was with bacteria, latex beads, lipopolysaccharide (LPS), or zymogen A. Subcellular organelle disposition was determined after is...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(02)00187-5

    authors： Hall IH,Schwab UE,Ward ES,Butts JD,Wolford ET,Ives TJ

    更新日期：2002-11-01 00:00:00

  • Knockdown of different influenza A virus subtypes in cell culture by a single antisense oligodeoxyribonucleotide.

    abstract：:Influenza is a heavy socially significant viral infection that affects humans, birds, and wild and domestic animals. The threat of existing and new highly pathogenic subtypes of influenza A virus (IAV) makes it necessary to develop an effective drug that may affect different IAV strains. For this purpose, oligodeoxynu...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2015.03.004

    authors： Levina AS,Repkova MN,Mazurkova NA,Makarevich EV,Ismagilov ZR,Zarytova VF

    更新日期：2015-07-01 00:00:00

  • Molecular characterisation of cyp51A and cyp51B genes coding for P450 14alpha-lanosterol demethylases A (CYP51Ap) and B (CYP51Bp) from voriconazole-resistant laboratory isolates of Aspergillus flavus.

    abstract：:Aspergillus flavus is the second most common Aspergillus spp. causing invasive infections in immunocompromised patients. Extensive prophylactic use of voriconazole (VCZ) in immunocompromised patients may enhance the selection of VCZ-resistant clinical isolates of A. flavus, compromising the effectiveness of this antif...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2008.06.018

    authors： Krishnan-Natesan S,Chandrasekar PH,Alangaden GJ,Manavathu EK

    更新日期：2008-12-01 00:00:00

  • In vitro activity of the novel fluorocycline TP-6076 against carbapenem-resistant Acinetobacter baumannii.

    abstract：:The activity of the novel, fully synthetic fluorocycline antibiotic TP-6076 against carbapenem-resistant Acinetobacter baumannii (CRAB) isolates with defined carbapenem resistance mechanisms was compared against reference antimicrobials with known activity against Acinetobacter spp. The susceptibility of 323 non-dupli...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.10.010

    authors： Seifert H,Stefanik D,Olesky M,Higgins PG

    更新日期：2020-01-01 00:00:00

  • Use of colistin-containing products within the European Union and European Economic Area (EU/EEA): development of resistance in animals and possible impact on human and animal health.

    abstract：:Since its introduction in the 1950s, colistin has been used mainly as a topical treatment in human medicine owing to its toxicity when given systemically. Sixty years later, colistin is being used as a last-resort drug to treat infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa, Acinetobacter bauman...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2015.06.005

    authors： Catry B,Cavaleri M,Baptiste K,Grave K,Grein K,Holm A,Jukes H,Liebana E,Lopez Navas A,Mackay D,Magiorakos AP,Moreno Romo MA,Moulin G,Muñoz Madero C,Matias Ferreira Pomba MC,Powell M,Pyörälä S,Rantala M,Ružauskas M,Sa

    更新日期：2015-09-01 00:00:00

  • Emergence of Escherichia coli sequence type 410 (ST410) with KPC-2 β-lactamase.

    abstract：:Fifteen carbapenem-non-susceptible Escherichia coli isolates obtained during the period May 2010 to April 2011 in a hospital and a long-term care facility (LTCF) in Larissa (Central Greece) were investigated. Minimum inhibitory concentrations (MICs) to various antimicrobial agents were determined by Etest. Carriage of...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2011.11.003

    authors： Mavroidi A,Miriagou V,Malli E,Stefos A,Dalekos GN,Tzouvelekis LS,Petinaki E

    更新日期：2012-03-01 00:00:00

  • Identification and screening for antimicrobial activity against Clostridium difficile of Bifidobacterium and Lactobacillus species isolated from healthy infant faeces.

    abstract：:The antimicrobial activity against Clostridium difficile of 109 lactic acid bacteria (LAB) isolated from 32 healthy Korean infants was measured. The ability to show similar activity against Escherichia coli O157:H7 and Staphylococcus aureus was also looked for. Twelve of the 109 LAB showed activity against C. difficil...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(02)00389-8

    authors： Lee YJ,Yu WK,Heo TR

    更新日期：2003-04-01 00:00:00

  • Resistance to third-generation cephalosporins in Escherichia coli in the French community: The times they are a-changin'?

    abstract：OBJECTIVES:Since the early 2000s, Escherichia coli resistance to third-generation cephalosporins (3GCs) has been increasing in all European countries, mainly due to the spread of extended spectrum β-lactamases (ESBLs). Here we present a retrospective study that combines resistance of E. coli to 3GCs and quinolones with...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.105909

    authors： Jeanvoine A,Bouxom H,Leroy J,Gbaguidi-Haore H,Bertrand X,Slekovec C

    更新日期：2020-05-01 00:00:00