Abstract：
:As treatment options for critically ill patients with multidrug-resistant bacteria diminish, older antibiotics such as fosfomycin are being investigated for use as last-resort drugs. Fosfomycin is a broad-spectrum antibiotic with activity both against Gram-positive and Gram-negative bacteria. The aim of this review was to examine the effectiveness of current fosfomycin dosing strategies in critically ill patients. These patients can be subject to pathophysiology that can impact antibiotic pharmacokinetic (PK) profiles and potentially the effectiveness of their treatment. As a hydrophilic drug with negligible protein binding, fosfomycin is eliminated almost entirely by glomerular filtration and is subject to patient renal function. If altered as seen in augmented renal clearance, renal function in a critically ill patient may lead to low blood concentrations and predispose patients to the risk of treatment failure. If altered as seen in acute kidney injury, toxic blood concentrations may develop. Fosfomycin has a volume of distribution comparable with β-lactams and aminoglycosides and may therefore increase in critically ill patients. Altered dosing strategies may be required to optimise dosing given these PK changes, although the current paucity of data on fosfomycin in critically ill patients prevents accurate dosing guidance being recommended at this time.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Parker S,Lipman J,Koulenti D,Dimopoulos G,Roberts JAdoi
10.1016/j.ijantimicag.2013.05.018subject
Has Abstractpub_date
2013-10-01 00:00:00pages
289-93issue
4eissn
0924-8579issn
1872-7913pii
S0924-8579(13)00209-4journal_volume
42pub_type
杂志文章,评审abstract：:No vaccine exists against any form of leishmaniasis. Because recovery from infection is usually accompanied by a strong immunity and because it is possible to protect experimental animals against live challenge, hope for the development of a vaccine for humans has been high. However, leishmaniasis is a disease of the ...
journal_title：International journal of antimicrobial agents
pub_type： 杂志文章,评审
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更新日期：2010-11-01 00:00:00
abstract：:This study aimed to assess the clinical impact and potential risk factors associated with polymyxin-resistant Enterobacteriaceae strains isolated from patients hospitalized in adult and neonatal intensive care units. A case-control study was conducted from September 2015 to January 2017. Antimicrobial susceptibility o...
journal_title：International journal of antimicrobial agents
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journal_title：International journal of antimicrobial agents
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更新日期：2005-02-01 00:00:00
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章
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更新日期：1997-06-01 00:00:00
abstract：OBJECTIVES:Since the early 2000s, Escherichia coli resistance to third-generation cephalosporins (3GCs) has been increasing in all European countries, mainly due to the spread of extended spectrum β-lactamases (ESBLs). Here we present a retrospective study that combines resistance of E. coli to 3GCs and quinolones with...
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pub_type： 杂志文章
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章
doi：10.1016/j.ijantimicag.2018.04.023
更新日期：2018-11-01 00:00:00
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章,评审
doi：10.1016/s0924-8579(00)00233-8
更新日期：2000-10-01 00:00:00
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章
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更新日期：2001-10-01 00:00:00
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章,评审
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更新日期：2003-05-01 00:00:00
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章,评审
doi：10.1016/j.ijantimicag.2007.07.019
更新日期：2007-12-01 00:00:00
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章
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更新日期：2001-12-01 00:00:00
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章
doi：10.1016/j.ijantimicag.2008.09.006
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pub_type： 杂志文章
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journal_title：International journal of antimicrobial agents
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pub_type： 临床试验,杂志文章,多中心研究
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pub_type： 杂志文章
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更新日期：2004-08-01 00:00:00
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abstract：:There is a lack of surveillance data on resistance to fusidic acid (FA) in Asia, and no reviews of FA usage for the treatment of orthopaedic infections have been conducted since the year 2000. In this study, we present a systemic literature review of FA resistance in Asia and the clinical use of FA for the treatment o...
journal_title：International journal of antimicrobial agents
pub_type： 杂志文章,评审
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章
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更新日期：2014-03-01 00:00:00
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journal_title：International journal of antimicrobial agents
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章
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更新日期：2002-11-01 00:00:00
abstract：:Owing to its high morbidity and mortality, nosocomial pneumonia represents a particularly serious illness and one of the most frequent complications in ventilated patients admitted to the Intensive Care Unit. Gram-negative microorganisms, such as Pseudomonas aeruginosa, Acinetobacter baumannii and Stenotrophomonas mal...
journal_title：International journal of antimicrobial agents
pub_type： 杂志文章,评审
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更新日期：2006-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-11-01 00:00:00
abstract：:Antimicrobial agents (AMAs) have been used in agriculture since the 1950s as growth-promoting agents [antimicrobial growth promoters (AGPs)]. They have provided benefits to the agricultural industry by increasing production efficiencies and maximising livestock health, yet the potential risks surrounding resistance to...
journal_title：International journal of antimicrobial agents
pub_type： 杂志文章,评审
doi：10.1016/j.ijantimicag.2016.08.006
更新日期：2017-01-01 00:00:00
