Abstract：
:There is a lack of surveillance data on resistance to fusidic acid (FA) in Asia, and no reviews of FA usage for the treatment of orthopaedic infections have been conducted since the year 2000. In this study, we present a systemic literature review of FA resistance in Asia and the clinical use of FA for the treatment of bone and joint infections (BJIs). The in vitro activity of FA against meticillin-resistant Staphylococcus aureus (MRSA) isolates remains good, with low (<10%) resistance rates in most Asian countries. FA in Asia appears to be a better oral anti-MRSA agent than trimethoprim/sulfamethoxazole and clindamycin. More than 80 cases of FA use for BJI have been reported since 2000 and the recurrence or failure rate is <10%. There is much evidence supporting the use of FA in combination with other antibiotics (e.g. rifampicin) as an oral treatment following intravenous glycopeptide treatment for BJIs.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Wang JL,Tang HJ,Hsieh PH,Chiu FY,Chen YH,Chang MC,Huang CT,Liu CP,Lau YJ,Hwang KP,Ko WC,Wang CT,Liu CY,Liu CL,Hsueh PRdoi
10.1016/j.ijantimicag.2012.03.010subject
Has Abstractpub_date
2012-08-01 00:00:00pages
103-7issue
2eissn
0924-8579issn
1872-7913pii
S0924-8579(12)00127-6journal_volume
40pub_type
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