Abstract:
:Since its introduction in the 1950s, colistin has been used mainly as a topical treatment in human medicine owing to its toxicity when given systemically. Sixty years later, colistin is being used as a last-resort drug to treat infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa, Acinetobacter baumannii and Enterobacteriaceae (e.g., Escherichia coli, Klebsiella pneumoniae), for which mortality can be high. In veterinary medicine, colistin has been used for decades for the treatment and prevention of infectious diseases. Colistin has been administered frequently as a group treatment for animal gastrointestinal infections caused by Gram-negative bacteria within intensive husbandry systems. Given the ever-growing need to retain the efficacy of antimicrobials used to treat MDR infections in humans, the use of colistin in veterinary medicine is being re-evaluated. Despite extensive use in veterinary medicine, there is limited evidence for the development of resistance to colistin and no evidence has been found for the transmission of resistance in bacteria that have been spread from animals to humans. Since surveillance for colistin resistance in animals is limited and the potential for such transmission exists, there is a clear need to reinforce systematic monitoring of bacteria from food-producing animals for resistance to colistin (polymyxins). Furthermore, colistin should only be used for treatment of clinically affected animals and no longer for prophylaxis of diseases, in line with current principles of responsible use of antibiotics.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Catry B,Cavaleri M,Baptiste K,Grave K,Grein K,Holm A,Jukes H,Liebana E,Lopez Navas A,Mackay D,Magiorakos AP,Moreno Romo MA,Moulin G,Muñoz Madero C,Matias Ferreira Pomba MC,Powell M,Pyörälä S,Rantala M,Ružauskas M,Sadoi
10.1016/j.ijantimicag.2015.06.005subject
Has Abstractpub_date
2015-09-01 00:00:00pages
297-306issue
3eissn
0924-8579issn
1872-7913pii
S0924-8579(15)00222-8journal_volume
46pub_type
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journal_title:International journal of antimicrobial agents
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journal_title:International journal of antimicrobial agents
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