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Treatment of symptomatic amebic colitis in human immunodeficiency virus-infected persons.

Abstract：

:While most Entamoeba histolytica appearing in male homosexuals infected with human immunodeficiency virus (HIV) is considered non-invasive in Western countries, and treatment of amebiasis in these persons has received very little attention, in Japan some male homosexual amebiasis patients infected with HIV complain of symptoms attributable to E. histolytica infection. We investigated whether symptomatic E histolytica amebic colitis in HIV-infected persons requires higher doses or longer duration of antiamebic drug therapy than in non HIV-infected patients. Four symptomatic amebic colitis patients infected with HIV-1, three of them severely immunocompromised, with CD4 cell counts <200/mm(3), were treated with oral metronidazole: 1500 mg a day for 10 days in 2 patients, 1000 mg a day for 10 days in 1 patient, and 1000 mg a day for 6 days and then 750 mg for 4 days in 1 patient, and good therapeutic results with no side effects were obtained. This indicates that symptomatic amebic colitis in HIV-infected persons can be successfully treated with metronidazole at the same dose and duration of treatment used in non-HIV-infected persons.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Ohnishi K,Murata M

doi

10.1016/s0924-8579(96)00327-5

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

231-3

issue

4

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(96)00327-5

journal_volume

7

pub_type

杂志文章

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