Abstract：
:Citrobacter freundii strain 4306 was isolated from a urine specimen of a patient in March 2006 in Palestine. This strain showed a unique multidrug resistance phenotype, as it was resistant both to 7-alpha-methoxy- and oxyimino-cephalosporins, including cefepime, cefpirome and monobactams, in addition to quinolones, streptomycin and trimethoprim/sulfamethoxazole. Clavulanic acid did not act synergistically with cephalosporins by the double-disk synergy test. Molecular characterisation showed that the resistance to 7-alpha-methoxy- and oxyimino-cephalosporins was due to a novel AmpC beta-lactamase, designated CMY-37, with an isoelectric point of approximately 9.0. CMY-37 is a variant of C. freundii chromosomal AmpC enzymes with at least seven amino acid substitutions. One of these substitutions, L316I, is located within the R2 loop that is considered the hotspot region responsible for the extended substrate spectrum in class C beta-lactamases. The blaCMY-37 gene was cloned and expressed in Escherichia coli TG1. CMY-37 is chromosomally encoded and is not associated with ISEcp1-like element. Phylogenetic analysis suggested that CMY-37 is the origin of many plasmid-mediated AmpC beta-lactamases. This study highlights the emergence of cefepime and cefpirome resistance in C. freundii owing to a new type of AmpC beta-lactamase.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Ahmed AM,Shimamoto Tdoi
10.1016/j.ijantimicag.2008.04.019subject
Has Abstractpub_date
2008-09-01 00:00:00pages
256-61issue
3eissn
0924-8579issn
1872-7913pii
S0924-8579(08)00198-2journal_volume
32pub_type
杂志文章abstract：:The purpose of this study was to compare the safety and efficacy of lomefloxacin with that of cefaclor in the treatment of adult secondary bacterial skin and skin structure infections. The study was conducted as a randomized, single-blind comparison. Eighty patients enrolled in the study, of which 74 were evaluable: 3...
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pub_type： 杂志文章
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更新日期：2017-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-03-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：International journal of antimicrobial agents
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journal_title：International journal of antimicrobial agents
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更新日期：2010-11-01 00:00:00
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journal_title：International journal of antimicrobial agents
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更新日期：2010-03-01 00:00:00
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