当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS期刊下所有文献 > Simplified dosing regimens of teicoplanin for patient groups stratified by renal function and weight using Monte Carlo simulation.

Simplified dosing regimens of teicoplanin for patient groups stratified by renal function and weight using Monte Carlo simulation.

Abstract：

:The purpose of this study was (i) to determine the optimal dosage of teicoplanin for each patient group stratified by renal function and weight based on a population pharmacokinetic model and observed distribution of patient characteristics and (ii) to develop new simplified dosing regimens designed to achieve 15-30 μg/mL. Patient data were collected retrospectively from routine therapeutic drug monitoring files of adult patients who were given the standard loading dose regimen of teicoplanin (400 mg twice on Day 1, followed by 400 mg once daily for 2 days) and whose trough concentration was measured just before administration on Day 4. Monte Carlo simulation was conducted to estimate the trough concentration at 72 h after the initial loading dose (C(min)(72 h)) and at steady state (C(ss)(min)). The percentage of observed C(min)(72 h) in patients who received the standard loading dose regimen outside the non-parametric 90% prediction interval (from 5th to 95th percentile) of the simulated C(min)(72 h) was <10%. Simplified loading dose and maintenance dose regimens for each group stratified by renal function and weight were created to achieve C(min)(72 h) and C(ss)(min) of 15 μg/mL and 20-25 μg/mL, respectively. The percentage of C(min)(72 h) and C(ss)(min) in the range 15-30 μg/mL was 43-65% and 61-82% across each renal function and weight strata, respectively. These new simplified dosing regimens of teicoplanin could be helpful in individual adjustment of the loading and maintenance doses to achieve 15-30 μg/mL.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Yamada T,Nonaka T,Yano T,Kubota T,Egashira N,Kawashiri T,Oishi R

doi

10.1016/j.ijantimicag.2012.05.025

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

344-8

issue

4

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(12)00256-7

journal_volume

40

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS文献大全
  • Current challenges in the diagnosis and management of invasive fungal infections: report from the 15th International Symposium on Infections in the Immunocompromised Host: Thessaloniki, Greece, 22-25 June 2008.

    abstract：:New, aggressive forms of immunosuppression and an increasing population of patients at risk provide fertile ground for opportunistic invasive fungal infections (IFIs). Particularly challenging is the changing epidemiology of IFIs: rare pathogens are now more common and resistant strains are emerging among species that...

    journal_title：International journal of antimicrobial agents

    pub_type：

    doi：10.1016/j.ijantimicag.2008.08.014

    authors： Groll AH,McNeil Grist L

    更新日期：2009-02-01 00:00:00

  • Genetic diversity of Streptococcus pneumoniae in Tunisia.

    abstract：OBJECTIVES:This study aimed to explore the genetic diversity of Streptococcus pneumoniae isolates in a Tunisian pneumology hospital. METHODS:A total of 141 S. pneumoniae strains isolated between 2009-2016 in the microbiology laboratory at A. Mami Hospital of Pneumology were investigated. Antimicrobial susceptibility t...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.09.023

    authors： Midouni B,Mehiri E,Ghariani A,Draoui H,Essalah L,Bouzouita I,Raoult D,Slim-Saidi L,Fournier PE

    更新日期：2019-01-01 00:00:00

  • In vitro and intracellular activities of fosfomycin against clinical strains of Listeria monocytogenes.

    abstract：:This study was designed to evaluate the potential role of fosfomycin as a therapeutic agent in human listeriosis. The in vitro activity of fosfomycin against 154 Listeria monocytogenes clinical isolates under conditions that mimic the induction of prfA expression was determined and was correlated with fosfomycin intra...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2013.10.018

    authors： Lepe JA,Torres MJ,Smani Y,Parra-Millán R,Pachón J,Vazquez-Barba I,Aznar J

    更新日期：2014-02-01 00:00:00

  • Activity of combinations of ceftazidime, imipenem and pefloxacin against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.

    abstract：:The chequerboard technique was used to look for synergistic combinations of ceftazidime, imipenem and pefloxacin. The synergistic combinations were used in vivo in mice experimentally infected with Escherichia coli, Salmonella typhimurium and Pseudomonas aeruginosa. In vitro ceftazidime/imipenem, ceftazidime/pefloxaci...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(03)00127-4

    authors： El-Sukhon SN,Faiza Boukhatem Z

    更新日期：2003-12-01 00:00:00

  • Prophylaxis, pre-emptive or empirical antifungal therapy: which is best in non-lung transplant recipients?

    abstract：:Renal, liver, heart and lung transplantation are now considered to be the standard therapeutic interventions in patients with end-stage organ failure. Infectious complications following solid organ transplantation (SOT) are relatively common owing to the transplant recipient's overall immunosuppressed status. The inci...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/S0924-8579(08)70017-7

    authors： Salavert M

    更新日期：2008-11-01 00:00:00

  • Subtleties in practical application of prolonged infusion of β-lactam antibiotics.

    abstract：:Prolonged infusion (PI) of β-lactam antibiotics is increasingly used in order to optimise antibiotic exposure in critically ill patients. Physicians are often not aware of a number of subtleties that may jeopardise the treatment. In this clinically based paper, we stress pragmatic issues, such as the importance of a l...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2015.01.007

    authors： De Waele JJ,Lipman J,Carlier M,Roberts JA

    更新日期：2015-05-01 00:00:00

  • Current and future approaches to antimycotic treatment in the era of resistant fungi and immunocompromised hosts.

    abstract：:Due to the ever-increasing number of immunocompromised patients, both localised and life-threatening systemic fungal infections are on the increase. Conventional treatment is of limited help, not in the least due to a less optimum benefit-to-risk ratio. Moreover, emerging pathogens with reduced antimicrobial susceptib...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/s0924-8579(00)00323-x

    authors： Bastert J,Schaller M,Korting HC,Evans EG

    更新日期：2001-02-01 00:00:00

  • Changes before and after a policy to restrict antimicrobial usage in upper respiratory infections in Taiwan.

    abstract：:The Bureau of National Health Insurance (BNHI) of Taiwan issued a new reimbursement regulation effective from 1 February 2001 forbidding the use of antimicrobials in ambulatory patients with upper respiratory infections (URI) without evidence of bacterial infection. We evaluated the effect of this regulation by analys...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2003.10.013

    authors： Ho M,Hsiung CA,Yu HT,Chi CL,Chang HJ

    更新日期：2004-05-01 00:00:00

  • Clinical features of patients with bacteraemia caused by Mycobacterium avium complex species and antimicrobial susceptibility of the isolates at a medical centre in Taiwan, 2008-2014.

    abstract：:Advanced molecular typing methods have greatly expanded the taxonomy of Mycobacterium avium complex (MAC) species; however, little is known about the epidemiology and clinical features of bacteraemia caused by different MAC species. In this study, the clinical characteristics of patients treated for MAC bacteraemia in...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.02.016

    authors： Lee MR,Chien JY,Huang YT,Liao CH,Shu CC,Yu CJ,Hsueh PR

    更新日期：2017-07-01 00:00:00

  • Do raspberry extracts and fractions have antifungal or anti-adherent potential against Candida spp.?

    abstract：:Candida spp., especially Candida albicans, is one of the main colonisers of the oral cavity. Due to its ability to form biofilms, it can be implicated in dental caries, periodontal disease and denture stomatitis. Microbial cells in biofilms are minimally impacted by conventional drugs. The aim of this study was to fin...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.08.020

    authors： Dutreix L,Bernard C,Juin C,Imbert C,Girardot M

    更新日期：2018-12-01 00:00:00

  • Five-year trends for ventilator-associated pneumonia: Correlation between microbiological findings and antimicrobial drug consumption.

    abstract：:The epidemiology of multidrug-resistant bacteria (MDRB) has changed significantly in European healthcare settings, with a decrease in frequency of meticillin-resistant Staphylococcus aureus and an increase in extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. Little is known about the effects of these ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2015.07.010

    authors： Fihman V,Messika J,Hajage D,Tournier V,Gaudry S,Magdoud F,Barnaud G,Billard-Pomares T,Branger C,Dreyfuss D,Ricard JD

    更新日期：2015-11-01 00:00:00

  • Vancomycin-associated nephrotoxicity: A meta-analysis of administration by continuous versus intermittent infusion.

    abstract：:Vancomycin is a glycopeptide antibiotic widely used in the management of meticillin-resistant Staphylococcus aureus (MRSA). Guidelines currently recommend vancomycin be administered by intermittent infusion, despite recent research suggesting that continuous infusion (CI) may be associated with lower rates of vancomyc...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ijantimicag.2015.04.013

    authors： Hanrahan T,Whitehouse T,Lipman J,Roberts JA

    更新日期：2015-09-01 00:00:00

  • Clinical efficacy, cost analysis and patient acceptability of outpatient parenteral antibiotic therapy (OPAT): a decade of Sheffield (UK) OPAT service.

    abstract：:Outpatient parenteral antimicrobial therapy (OPAT) has evolved relatively slowly in the UK. This study describes the OPAT service based in a large UK teaching hospital in Sheffield, and examines the clinical efficacy, patient acceptability and costs saved over a 10-year period. Data on 3812 episodes of OPAT administer...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.03.016

    authors： Durojaiye OC,Bell H,Andrews D,Ntziora F,Cartwright K

    更新日期：2018-01-01 00:00:00

  • Surveillance of antimicrobial resistance among Escherichia coli in wastewater in Stockholm during 1 year: does it reflect the resistance trends in the society?

    abstract：:The resistance patterns of Escherichia coli in untreated (raw) urban wastewater (UW) was monitored by repeated sampling during 1 year. Comparison with data from wastewater samples collected from hospital wastewater (HW) in the same urban area was made. A total of 1326 E. coli isolates from 17 UW samples and 451 isolat...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2014.09.016

    authors： Kwak YK,Colque P,Byfors S,Giske CG,Möllby R,Kühn I

    更新日期：2015-01-01 00:00:00

  • Tuberculosis in patients with systemic rheumatic or pulmonary diseases treated with glucocorticosteroids and the preventive role of isoniazid: a review of the available evidence.

    abstract：:Development of tuberculosis (TB) is a concern in patients who receive glucocorticosteroids for the treatment of chronic rheumatic or pulmonary diseases. However, the incidence of development of TB in such patients and the prophylactic role of isoniazid (INH) are unclear. We evaluated the available evidence from 20 rel...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2007.07.010

    authors： Falagas ME,Voidonikola PT,Angelousi AG

    更新日期：2007-12-01 00:00:00

  • Antimicrobial drug resistance in Taiwan.

    abstract：:Antimicrobial resistance is a major health problem worldwide, but marked variations in the resistance profiles of bacterial pathogens are found between countries and in different patient settings, especially in Asia. In Taiwan, the strikingly high prevalence of resistance to macrolides and streptogramins in clinical i...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/S0924-8579(08)70023-2

    authors： Huang YT,Hsueh PR

    更新日期：2008-11-01 00:00:00

  • Point prevalence survey of antibiotic use in Scottish hospitals utilising the Glasgow Antimicrobial Audit Tool (GAAT).

    abstract：:A point prevalence survey of antimicrobial prescribing was performed in 10 Scottish hospitals using the Glasgow Antimicrobial Audit Tool (GAAT). Appropriateness of the intravenous (IV) route was determined by an infectious diseases physician (IDP) and by a computerised algorithm. The IDP also estimated IV agent approp...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.10.020

    authors： Seaton RA,Nathwani D,Burton P,McLaughlin C,MacKenzie AR,Dundas S,Ziglam H,Gourlay Y,Beard K,Douglas E

    更新日期：2007-06-01 00:00:00

  • Epidemiological shifts in opportunistic and nosocomial Candida infections: mycological aspects.

    abstract：:Increases in the prevalence of yeast species other than C. albicans as agents of disseminated mycoses in immunosuppressed patients and of fluconazole-resistant C. albicans isolates from patients infected with HIV indicate changes in the epidemiology of Candida infections. The precise reasons for alterations in prevale...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/0924-8579(95)00049-6

    authors： Odds FC

    更新日期：1996-02-01 00:00:00

  • In vitro activity of KRM-1648, either singly or in combination with ofloxacin, against Mycobacterium ulcerans.

    abstract：:The antimicrobial effect of a benzoxazinorifamycin, KRM-1648, either alone or in combination with ofloxacin, was evaluated in vitro against two type strains and six clinical isolates of Mycobacterium ulcerans. Growth of M. ulcerans was measured by plate counts and the BACTEC radiometric method. The minimal inhibitory ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(00)00306-x

    authors： Dhople AM

    更新日期：2001-01-01 00:00:00

  • Increased rifampicin resistance in blood isolates of meticillin-resistant Staphylococcus aureus (MRSA) amongst patients exposed to rifampicin-containing antituberculous treatment.

    abstract：:The aim of this study was to determine the rifampicin (RIF) resistance rate of meticillin-resistant Staphylococcus aureus (MRSA) amongst patients with MRSA bacteraemia who have or have not been exposed to RIF-containing antituberculous (anti-TB) treatment. From 2000 to 2008, patients with MRSA bacteraemia and previous...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2011.01.018

    authors： Tan CK,Lai CC,Liao CH,Lin SH,Huang YT,Hsueh PR

    更新日期：2011-06-01 00:00:00

  • Cranberry high molecular weight constituents promote Streptococcus sobrinus desorption from artificial biofilm.

    abstract：:Dental biofilm harbouring oral bacteria is highly correlated with the progression of dental diseases. Disruption of biofilm formation via anti-adhesion agents is an alternative means to the antibacterial approach. Previous studies have shown that high molecular weight non-dialysable material (NDM) derived from cranber...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.10.014

    authors： Steinberg D,Feldman M,Ofek I,Weiss EI

    更新日期：2005-03-01 00:00:00

  • Assessing antimicrobial stewardship initiatives: Clinical evaluation of cefepime or piperacillin/tazobactam in patients with bloodstream infections secondary to AmpC-producing organisms.

    abstract：:Management of micro-organisms harbouring AmpC β-lactamases remains challenging. Carbapenems are often considered first-line agents. Due to growing concern regarding carbapenem-resistant Enterobacteriaceae, integrating non-carbapenem treatment strategies is being explored for these pathogens. The primary objective of t...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.08.007

    authors： McKamey L,Venugopalan V,Cherabuddi K,Borgert S,Voils S,Shah K,Klinker KP

    更新日期：2018-11-01 00:00:00

  • Transcriptional profiling of the two-component regulatory system VraSR in Staphylococcus aureus with low-level vancomycin resistance.

    abstract：:The objective of this study was to comprehensively identify the target genes regulated by the two-component regulatory system VraSR in Staphylococcus aureus and to clarify the role of VraSR in low-level vancomycin resistance. Expression of vraS was determined by real-time quantitative reverse transcriptase PCR (qRT-PC...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.02.003

    authors： Chen H,Xiong Z,Liu K,Li S,Wang R,Wang X,Zhang Y,Wang H

    更新日期：2016-05-01 00:00:00

  • Inhibitory activity of bovine lactoferrin against echovirus induced programmed cell death in vitro.

    abstract：:Lactoferrin is a glycoprotein and plays an important role in defence against pathogens. Although the antiviral activity of lactoferrin is one of the major biological functions of such protein, the mechanism of action is still under debate. The effect of lactoferrin on echovirus 6 infection in vitro was analysed and re...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2005.02.011

    authors： Tinari A,Pietrantoni A,Ammendolia MG,Valenti P,Superti F

    更新日期：2005-05-01 00:00:00

  • Subinhibitory concentrations of beta-lactams and other cell-wall antibiotics inhibit listeriolysin production by Listeria monocytogenes.

    abstract：:In the present study we tested the ability of beta-lactam antibiotics and other cell-wall antibiotics to inhibit the production of listeriolysin which is the main virulence factor of L. monocytogenes. The amount of listeriolysin produced was measured in the supernatants with a sensitive hemolysin assay and as beta-gal...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/0924-8579(96)00014-3

    authors： Nichterlein T,Domann E,Kretschmar M,Bauer M,Hlawatsch A,Hof H,Chakraborty T

    更新日期：1996-05-01 00:00:00

  • Strategies for the control of catheter encrustation.

    abstract：:Two general strategies have been adopted to develop catheter materials that resist encrustaion by bacterial biofilms: (a) the incorporation of antimicrobial agents into the polymers and (b) the production of materials with surface properties which prevent the adherence of bacterial cells. Our experience to develop non...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(02)00091-2

    authors： Stickler DJ,Evans A,Morris N,Hughes G

    更新日期：2002-06-01 00:00:00

  • Colistin resistance emerges in pandrug-resistant Klebsiella pneumoniae epidemic clones in Rio de Janeiro, Brazil.

    abstract：:Klebsiella pneumoniae is an important human pathogen, able to accumulate and disseminate a variety of antimicrobial resistance genes. Resistance to colistin, one of the last therapeutic options for multi-drug-resistant bacteria, has been reported increasingly. Colistin-resistant K. pneumoniae (ColRKp) emerged in two h...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.08.017

    authors： Longo LGA,de Sousa VS,Kraychete GB,Justo-da-Silva LH,Rocha JA,Superti SV,Bonelli RR,Martins IS,Moreira BM

    更新日期：2019-11-01 00:00:00

  • The role of the hospital pharmacist in cost control and antibiotic policy.

    abstract：:The pharmacist provides a vital role in the management of antibiotic policy. Consumers and payers demand quality care at a significantly reduced price. It is imperative that health care adapt to the times. Physicians must be involved in all phases of programmes that are viewed as cost saving. These programmes should i...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(00)00250-8

    authors： Milkovich G

    更新日期：2000-11-01 00:00:00

  • Resistance to macrolides by ribosomal mutation in clinical isolates of Turicella otitidis.

    abstract：:The genetic basis of erythromycin resistance in Turicella otitidis, a coryneform bacteria associated with otitis, was studied in five macrolide-resistant clinical isolates. Macrolide resistance genes were searched for by polymerase chain reaction (PCR). Genes for domain V of 23S rRNA (rrl) as well as rplD (L4 protein)...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2009.03.023

    authors： Boumghar-Bourtchai L,Chardon H,Malbruny B,Mezghani S,Leclercq R,Dhalluin A

    更新日期：2009-09-01 00:00:00

  • Dissemination of carbapenem-resistant Pseudomonas aeruginosa isolates and their susceptibilities to ceftolozane-tazobactam in Germany.

    abstract：:Pseudomonas aeruginosa (PA) is a major cause of healthcare-associated infections. Antipseudomonal carbapenems are among the antimicrobial agents used to treat PA infections, but several mechanisms of resistance, including the production of a carbapenemase (CP), may compromise their clinical efficacy. The objectives of...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.105959

    authors： Kresken M,Körber-Irrgang B,Korte-Berwanger M,Pfennigwerth N,Gatermann SG,Seifert H,German Carbapenem Resistance Study Group.

    更新日期：2020-06-01 00:00:00