Abstract:
:Dental biofilm harbouring oral bacteria is highly correlated with the progression of dental diseases. Disruption of biofilm formation via anti-adhesion agents is an alternative means to the antibacterial approach. Previous studies have shown that high molecular weight non-dialysable material (NDM) derived from cranberry juice inhibits the adhesion of Escherichia coli and the coaggregation of a variety of oral bacteria. In addition, it inhibits the formation of glucans and fructans synthesised by GTF and FTF. In the present study, we examined the anti-adhesion effect of NDM on S. sobrinus. NDM promoted desorption of S. sobrinus from biofilm in the presence and absence of extracellular glucans and fructans, although the effect was more pronounced in the absence of these polysaccharides. Precoating of the bacteria with NDM reduced their ability to form biofilm. Our results indicate that NDM could be exploited as an anti-biofilm agent.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Steinberg D,Feldman M,Ofek I,Weiss EIdoi
10.1016/j.ijantimicag.2004.10.014subject
Has Abstractpub_date
2005-03-01 00:00:00pages
247-51issue
3eissn
0924-8579issn
1872-7913pii
S0924-8579(04)00437-6journal_volume
25pub_type
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