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Integron presence in a multiresistant Morganella morganii isolate.

Abstract：

:A multiresistant strain of Morganella morganii was isolated from a patient affected by several severe pathologies. The isolate was found to be resistant to the following antimicrobials: ampicillin, nalidixic acid, cefalothin, cefoxitin, ceftriaxone, ciprofloxacin, chloramphenicol, streptomycin, erythromycin, gentamicin, novobiocin, penicillin, rifampicin, tetracycline and violet crystal. Mechanisms leading to this multiresistance were studied. Porins of M. morganii multiresistant and wild-type strains were analysed by sodium dodecylsulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and were characterised by their ability to form channels in planar black lipid bilayers. The channels formed by porins from multiresistant and susceptible strains suggested that the porins of the multiresistant strain were not responsible for resistance. A 6.6 kb plasmid (pML2003) was detected, isolated and studied. pML2003 included two integrons. Direct sequencing revealed that one of the integrons contained two cassettes, aminoglycoside adenyltransferase (aadB) and chloramphenicol acetyltransferase (catB3) conferring resistance to aminoglycosides and chloramphenicol, respectively. The second integron contained carbenicillinase (blaP1b) and adenyltransferase (aadA2), which confer resistance to beta-lactamases and streptomycin, respectively.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Rojas L,Vinuesa T,Tubau F,Truchero C,Benz R,Viñas M

doi

10.1016/j.ijantimicag.2006.01.006

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

505-12

issue

6

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(06)00084-7

journal_volume

27

pub_type

杂志文章

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