当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS期刊下所有文献 > The safety of azithromycin in the treatment of adults with community-acquired respiratory tract infections.

The safety of azithromycin in the treatment of adults with community-acquired respiratory tract infections.

Abstract：

:The comparative safety of azithromycin was assessed in adult patients (> or =12 years) with community-acquired respiratory tract infections. Of 3229 patients evaluated, 1616 received azithromycin 500 mg once daily for 3 days and 1613 received standard regimens of amoxycillin, amoxycillin/clavulanic acid, cefaclor, clarithromycin, or roxithromycin. A similar incidence of treatment-related adverse events occurred with azithromycin (10.3%) and comparators (11.5%). Significantly fewer patients were withdrawn from azithromycin than comparator treatment (0.4 versus 2.1%; P=0.0001). Most adverse events were mild/moderate in intensity and affected the gastrointestinal system. Azithromycin was as well tolerated as other antibiotics commonly used for bacterial infections in adults.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Treadway G,Pontani D,Reisman A

doi

10.1016/s0924-8579(01)00490-3

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

189-94

issue

3

eissn

0924-8579

issn

1872-7913

pii

S0924857901004903

journal_volume

19

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS文献大全
  • Pharmacokinetic/pharmacodynamic modeling of in vitro activity of azithromycin against four different bacterial strains.

    abstract：:The bacterial time-kill curves of azithromycin against four bacterial strains (Streptococcus pneumoniae/penicillin-intermediate, S. pneumoniae/penicillin-sensitive, Haemophilus influenzae and Moraxella catarrhalis) were determined by in vitro infection models. Eighteen different pharmacokinetic/pharmacodynamic models ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.08.049

    authors： Treyaprasert W,Schmidt S,Rand KH,Suvanakoot U,Derendorf H

    更新日期：2007-03-01 00:00:00

  • Drivers and impact of antifungal therapy in critically ill patients with Aspergillus-positive respiratory tract cultures.

    abstract：:Invasive pulmonary aspergillosis (IPA) is an increasingly recognised problem in critically ill patients. Little is known about how intensivists react to an Aspergillus-positive respiratory sample or the efficacy of antifungal therapy (AFT). This study aimed to identify drivers of AFT prescription and diagnostic workup...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.05.017

    authors： Paiva JA,Mergulhão P,Gomes A,Taccone FS,Van den Abeele AM,Bulpa P,Misset B,Meersseman W,Dimopoulos G,Rello J,Vogelaers D,Blot S

    更新日期：2017-10-01 00:00:00

  • Synergistic effect between nisin and polymyxin B against pandrug-resistant and extensively drug-resistant Acinetobacter baumannii.

    abstract：:Acinetobacter baumannii is an opportunistic pathogen predominantly associated with nosocomial infections. The World Health Organization's data on antibiotic-resistant 'priority pathogens' reports carbapenem-resistant A. baumannii as a pathogen which is in critical need of research and development of new antimicrobials...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.03.009

    authors： Thomas VM,Brown RM,Ashcraft DS,Pankey GA

    更新日期：2019-05-01 00:00:00

  • Molecular characterisation of macrolide resistance mechanisms of Streptococcus pneumoniae and Streptococcus pyogenes isolated in Germany, 2002-2003.

    abstract：:In the present study, a real-time PCR protocol was developed for the detection of macrolide resistance determinants and was validated in a nationwide study in Germany covering a total of 236 Streptococcus pyogenes and 241 Streptococcus pneumoniae strains collected from children < or = 16 years of age with community-ac...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.02.020

    authors： Reinert RR,Franken C,van der Linden M,Lütticken R,Cil M,Al-Lahham A

    更新日期：2004-07-01 00:00:00

  • Analysis of topoisomerase mutations in fluoroquinolone-resistant and -susceptible Campylobacter jejuni strains isolated in Senegal.

    abstract：:In this study, topoisomerase mutations in ciprofloxacin-resistant and -susceptible Campylobacter jejuni were analysed by DNA sequencing. In certain ciprofloxacin-resistant C. jejuni, the mechanism of resistance was complex. The Thr86-Ala substitution in the GyrA protein appears to play a role in increasing the minimum...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.11.012

    authors： Kinana AD,Cardinale E,Bahsoun I,Tall F,Sire JM,Garin B,Boye CS,Dromigny JA,Perrier-Gros-Claude JD

    更新日期：2007-04-01 00:00:00

  • Interaction of local anaesthetics with other antifungal agents against pathogenic Aspergillus.

    abstract：:Aspergillus spp. are responsible for an increasing number of fungal infections in immunocompromised and transplant patients. Local anaesthetics (LAs) are growth inhibitors of bacteria and yeasts. Subinhibitory concentrations of the LAs lidocaine and bupivacaine blocked the germination of Aspergillus fumigatus, Aspergi...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2005.11.011

    authors： Rodrigues AG,Araujo R,Pina-Vaz C

    更新日期：2006-04-01 00:00:00

  • Assessing antimicrobial stewardship initiatives: Clinical evaluation of cefepime or piperacillin/tazobactam in patients with bloodstream infections secondary to AmpC-producing organisms.

    abstract：:Management of micro-organisms harbouring AmpC β-lactamases remains challenging. Carbapenems are often considered first-line agents. Due to growing concern regarding carbapenem-resistant Enterobacteriaceae, integrating non-carbapenem treatment strategies is being explored for these pathogens. The primary objective of t...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.08.007

    authors： McKamey L,Venugopalan V,Cherabuddi K,Borgert S,Voils S,Shah K,Klinker KP

    更新日期：2018-11-01 00:00:00

  • Drug combinations with amoxycillin reduce selection of clarithromycin resistance during Helicobacter pylori eradication therapy.

    abstract：:This study investigated the relationship between the drug combinations of the eradication regimens and the prevalence of acquired resistance to clarithromycin. Of 540 patients treated with anti-Helicobacter pylori regimens containing clarithromycin, 55 patients (31 males, mean age, 45.6 years) with failed eradication ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(01)00456-3

    authors： Murakami K,Fujioka T,Okimoto T,Sato R,Kodama M,Nasu M

    更新日期：2002-01-01 00:00:00

  • Review and mapping of carbapenem-resistant Enterobacteriaceae in Africa: Using diverse data to inform surveillance gaps.

    abstract：:Carbapenem-resistant Enterobacteriaceae (CRE) are among the most difficult to treat emerging multidrug-resistant organisms. Major limitations exist in surveillance needed to address CRE, particularly in areas with inadequate resources. We utilised optimised strategies to search for data on carbapenem susceptibility of...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2018.05.019

    authors： Mitgang EA,Hartley DM,Malchione MD,Koch M,Goodman JL

    更新日期：2018-09-01 00:00:00

  • Combination therapy with polymyxin B for carbapenemase-producing Klebsiella pneumoniae bloodstream infection.

    abstract：:Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) bloodstream infections (BSIs) are related to high mortality rates, and combination therapy has been associated with lower mortality in patients treated mostly with colistin. There is a paucity of studies addressing polymyxin B (PMB) treatment for KPC...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.10.010

    authors： Medeiros GS,Rigatto MH,Falci DR,Zavascki AP

    更新日期：2019-02-01 00:00:00

  • Pharmacokinetic and pharmacodynamic profiling of cefepime in plasma and peritoneal fluid of abdominal surgery patients.

    abstract：:This study was conducted to characterise the pharmacokinetics and pharmacodynamics of cefepime in plasma and peritoneal fluid (PF). One gram of cefepime was administered to eight laparotomy patients and plasma and PF samples were collected at the end of 0.5 h infusion and every hour for 6 h. Drug concentrations were d...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2007.04.012

    authors： Ikawa K,Morikawa N,Hayato S,Ikeda K,Ohge H,Sueda T

    更新日期：2007-09-01 00:00:00

  • Meta-analysis and systematic review of the efficacy and resistance for human immunodeficiency virus type 1 integrase strand transfer inhibitors.

    abstract：:Integrase strand transfer inhibitors (INSTIs) are the most recent class of antiretroviral drugs with potent and durable antiviral activity used to treat human immunodeficiency virus type 1 (HIV-1) infection. However, development of drug resistance increases the risk of treatment failure, disease progression and mortal...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ijantimicag.2019.08.008

    authors： Yang LL,Li Q,Zhou LB,Chen SQ

    更新日期：2019-11-01 00:00:00

  • Antibacterial activity of moxifloxacin against periodontal anaerobic pathogens involved in systemic infections.

    abstract：:The in vitro activity of moxifloxacin was compared with that of penicillin G, amoxycillin/clavulanate, cefoxitin, erythromycin, clindamycin and metronidazole against 158 isolates associated with periodontal infections. MIC(50)/MIC(90) values of moxifloxacin were respectively 0.06/0.5 mg/l for Porphyromonas gingivalis ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(02)00190-5

    authors： Milazzo I,Blandino G,Musumeci R,Nicoletti G,Lo Bue AM,Speciale A

    更新日期：2002-12-01 00:00:00

  • 'To bead or not to bead?' Treatment of osteomyelitis and prosthetic joint-associated infections with gentamicin bead chains.

    abstract：:Gentamicin-containing polymethylmethacrylate (PMMA) beads are frequently used to prevent and treat orthopaedic infections. The beads are typically inserted to fill anatomical defects secondary to surgical debridement. Local gentamicin use results in low serum levels whilst achieving high concentrations at the site of ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2011.03.008

    authors： Barth RE,Vogely HC,Hoepelman AI,Peters EJ

    更新日期：2011-11-01 00:00:00

  • Contribution of β-lactamase and efflux pump overproduction to tazobactam-piperacillin resistance in clinical isolates of Escherichia coli.

    abstract：INTRODUCTION:Tazobactam-piperacillin (TZP) is a mixture of a broad-spectrum penicillin and an irreversible β-lactamase inhibitor. TZP is effective against Gram-negative bacteria that produce extended-spectrum β-lactamases, and it is used as a first-line or second-line drug to treat serious infections. METHODS:This stu...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.105919

    authors： Suzuki Y,Sato T,Fukushima Y,Nakajima C,Suzuki Y,Takahashi S,Yokota SI

    更新日期：2020-04-01 00:00:00

  • Simultaneous detection of mutations associated with resistance to macrolides and quinolones in Campylobacter jejuni and C. coli using a PCR-line probe assay.

    abstract：:Quinolone and macrolide resistance of Campylobacter jejuni and Campylobacter coli mainly depend on a mutation in gyrA and in 23S rDNA, respectively. In order to detect quinolone and/or macrolide resistant C. jejuni and C. coli strains, a macrolide and quinolone line probe assay (MQ-LiPA) was developed and 42 C. jejuni...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(03)00178-x

    authors： Niwa H,Chuma T,Okamoto K,Itoh K

    更新日期：2003-10-01 00:00:00

  • Azole resistance mechanisms in Aspergillus: update and recent advances.

    abstract：:Aspergillus fumigatus is the main causal agent of invasive aspergillosis (IA), however other species of the genus can also cause IA, such as Aspergillus flavus, Aspergillus terreus, Aspergillus niger and related cryptic species. This infectious disease mainly affects immunosuppressed patients and is linked to elevated...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2019.09.011

    authors： Pérez-Cantero A,López-Fernández L,Guarro J,Capilla J

    更新日期：2020-01-01 00:00:00

  • Investigations into the in vitro antimicrobial activity and mode of action of the phenazine antibiotic D-alanylgriseoluteic acid.

    abstract：:D-Alanylgriseoluteic acid (AGA) is a potent antimicrobial phenazine compound produced by Pantoea agglomerans (Erwinia herbicola) Eh1087. Susceptibility tests against a range of microbes indicated that AGA had a broad spectrum of antimicrobial activity and was particularly active against Gram-positive pathogens. Compar...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.08.028

    authors： Giddens SR,Bean DC

    更新日期：2007-01-01 00:00:00

  • Acquired sulphonamide resistance genes in faecal Escherichia coli from healthy children in Bolivia and Peru.

    abstract：:Antimicrobial resistance and sulphonamide resistance determinants were studied in 20 co-trimoxazole resistant Escherichia coli in faecal samples from healthy children in Bolivia and Peru. Methods used were disc diffusion susceptibility tests, PCR, sequence analysis and plasmid conjugation assays. All isolates but one ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.12.004

    authors： Infante B,Grape M,Larsson M,Kristiansson C,Pallecchi L,Rossolini GM,Kronvall G

    更新日期：2005-04-01 00:00:00

  • Population pharmacokinetics and dosing optimization of latamoxef in neonates and young infants.

    abstract：OBJECTIVES:There has been recent renewed interest in historical antibiotics because of the increased antibiotic-resistant bacterial strains. Latamoxef, a semi-synthetic oxacephem antibiotic developed in 1980s, has recently been brought back into use for treatment of infections in newborns; however, it is still used off...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.11.017

    authors： Qi H,Kou C,Qi YJ,Tang BH,Wu YE,Jin F,Luo XJ,Shen YH,Guo YJ,Qi X,Wang YC,Dong Q,Chen XK,Shi HY,Zheng Y,Zhao W,Shen AD

    更新日期：2019-03-01 00:00:00

  • Pharmacokinetics of dolutegravir 100 mg once daily with rifampicin.

    abstract：BACKGROUND:Tuberculosis (TB) causes 25% of all deaths among individuals infected with human immunodeficiency virus (HIV). Rifampicin (RIF) is a potent inducer of drug metabolizing enzymes and drug transporters, and co-administration with dolutegravir (DTG) reduces DTG exposure; this can be overcome by doubling the DTG ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.04.009

    authors： Wang X,Cerrone M,Ferretti F,Castrillo N,Maartens G,McClure M,Boffito M

    更新日期：2019-08-01 00:00:00

  • Outpatient parenteral antibiotic therapy (OPAT) in different countries: a comparison.

    abstract：:In order to assess how outpatient parenteral antibiotic therapy (OPAT) is managed in different countries, we analyzed the data collected in the USA, UK and Italy by the International OPAT Registry using an ad hoc Access/Excel Microsoft program. The analysis of data concerned 9826 patients in the USA, 981 in the UK and...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.06.004

    authors： Esposito S,Noviello S,Leone S,Tice A,Seibold G,Nathwani D,Scaglione F,International OPAT Registry.

    更新日期：2004-11-01 00:00:00

  • Appropriate use of antimicrobials: the peculiarity of septic patients.

    abstract：:The treatment of bloodstream infections remains a significant challenge, with persisting high mortality and morbidity. To optimize antimicrobial therapy, the clinician must possess knowledge of the pharmacokinetic and pharmacodynamic properties of commonly used antimicrobials, and how these parameters may be affected ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/S0924-8579(09)70568-0

    authors： Scaglione F

    更新日期：2009-01-01 00:00:00

  • Survey of extended-spectrum beta-lactamases in Escherichia coli isolates from a Portuguese hospital and characterisation of a novel class 1 integron (In60A) carrying the blaCTX-M-9 gene.

    abstract：:Between November 2001 and November 2004, 231 Escherichia coli isolates resistant to beta-lactam antibiotics were identified. In 14 isolates, bla(TEM-24) (2 isolates), bla(TEM-52) (5 isolates) and bla(TEM-26) (7 isolates) were identified. In 145 E. coli isolates with the same M13 fingerprinting profile and the same res...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.08.002

    authors： Brizio A,Vasco S,Gonçalves AR,Lito LM,Cristino JM,Salgado MJ,Duarte A

    更新日期：2006-10-01 00:00:00

  • Fusidic acid for the treatment of bone and joint infections caused by meticillin-resistant Staphylococcus aureus.

    abstract：:There is a lack of surveillance data on resistance to fusidic acid (FA) in Asia, and no reviews of FA usage for the treatment of orthopaedic infections have been conducted since the year 2000. In this study, we present a systemic literature review of FA resistance in Asia and the clinical use of FA for the treatment o...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2012.03.010

    authors： Wang JL,Tang HJ,Hsieh PH,Chiu FY,Chen YH,Chang MC,Huang CT,Liu CP,Lau YJ,Hwang KP,Ko WC,Wang CT,Liu CY,Liu CL,Hsueh PR

    更新日期：2012-08-01 00:00:00

  • Antifungal resistance in Candida spp. isolated in Italy between 2002 and 2005 from children and adults.

    abstract：:The activity of amphotericin B, fluconazole, flucytosine, itraconazole and voriconazole was tested in vitro against 618 clinical Candida spp. isolates, using the broth microdilution or the disk diffusion method (voriconazole). Amphotericin B and voriconazole were the most potent antifungal agents assayed (100% of susc...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.08.047

    authors： Gualco L,Debbia EA,Bandettini R,Pescetto L,Cavallero A,Ossi MC,Schito AM,Marchese A

    更新日期：2007-02-01 00:00:00

  • In-vitro development of an effective treatment for Acanthamoeba keratitis.

    abstract：:The aim of this study was to develop an in-vitro topical treatment for Acanthamoeba keratitis (AK) effective against cysts and trophozoites. Qualitative assays were performed with voriconazole, chlorhexidine, propamidine, cellulase, tobramycin, ciprofloxacin and paromomycin as monotherapy and various combinations. Rib...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.03.033

    authors： Ortillés Á,Belloc J,Rubio E,Fernández MT,Benito M,Cristóbal JÁ,Calvo B,Goñi P

    更新日期：2017-09-01 00:00:00

  • Population pharmacokinetics of tobramycin in hospitalized patients receiving once-daily dosing regimen.

    abstract：:The population pharmacokinetics of tobramycin was investigated in a group of 327 adult hospitalized patients receiving once-daily administration of tobramycin at a dose of 7 mg kg(-1). The patients had an average age of 57+/-18 y and an average weight of 65+/-14 kg; 153 of the patients were female. Data, comprised of ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(00)00172-2

    authors： Xuan D,Lu JF,Nicolau DP,Nightingale CH

    更新日期：2000-08-01 00:00:00

  • Target site bacterial killing of cefpirome and fosfomycin in critically ill patients.

    abstract：:We employed an in-vivo pharmacokinetic/in-vitro pharmacodynamic method to simulate bacterial killing in plasma and the interstitium of skeletal muscle tissue after intravenous administration of 2 g of cefpirome and 8 g of fosfomycin alone and in combination to patients with sepsis. Interstitial antimicrobial concentra...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(03)00047-5

    authors： Zeitlinger MA,Marsik C,Georgopoulos A,Müller M,Heinz G,Joukhadar C

    更新日期：2003-06-01 00:00:00

  • Beneficial effect of combination antiplatelet therapy on the development of experimental Staphylococcus aureus endocarditis.

    abstract：:Previous studies in our laboratory have shown that antiplatelet agents, aspirin and ticlopidine, in clinically relevant concentrations influence the development and treatment of experimental endocarditis. To study the influence of combination antiplatelet treatment on the development of aortic vegetations, infected an...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(98)00092-2

    authors： Nicolau DP,Tessier PR,Nightingale CH

    更新日期：1999-02-01 00:00:00