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Investigations into the in vitro antimicrobial activity and mode of action of the phenazine antibiotic D-alanylgriseoluteic acid.

Abstract：

:D-Alanylgriseoluteic acid (AGA) is a potent antimicrobial phenazine compound produced by Pantoea agglomerans (Erwinia herbicola) Eh1087. Susceptibility tests against a range of microbes indicated that AGA had a broad spectrum of antimicrobial activity and was particularly active against Gram-positive pathogens. Comparison of the in vitro efficacy of AGA with eight other antibiotics against 119 clinical isolates of Streptococcus pneumoniae demonstrated that all were inhibited by low concentrations of AGA (minimal inhibitory concentration range

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Giddens SR,Bean DC

doi

10.1016/j.ijantimicag.2006.08.028

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

93-7

issue

1

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(06)00386-4

journal_volume

29

pub_type

杂志文章

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