Abstract:
:It has been previously demonstrated that some antimicrobial agents enhance activities of human polymorphonuclear neutrophils (PMNs). The effect on the release of cytokines in an inflammatory context from PMNs by these antibiotics was evaluated. We studied the effect of the release of some cytokines by human PMNs RT-PCR analysis on a clinical strain of Klebsiella pneumoniae by comparing the effect with that observed in the presence of co-amoxiclav, sanfetrinem, clarithromycin, prulifloxacin and tobramycin. All the drugs tested were capable of modulating PMN synthesis in vitro of pro-inflammatory cytokines IL-8, IL-1beta, TNF-alpha and IL-6, but not that of anti-inflammatory cytokine IL-10. The degree of their stimulatory or inhibitory potency varied with the cytokine examined.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Reato G,Cuffini AM,Tullio V,Mandras N,Roana J,Banche G,Foa R,Carlone NAdoi
10.1016/j.ijantimicag.2003.07.006subject
Has Abstractpub_date
2004-02-01 00:00:00pages
150-4issue
2eissn
0924-8579issn
1872-7913pii
S0924857903003807journal_volume
23pub_type
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