Serum concentrations and pharmacokinetics of moxifloxacin in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass.

Abstract:

:Although cephalosporins are recommended as primary agents, moxifloxacin may be a suitable second-line antibiotic in cardiac surgery, especially if additional Gram-negative coverage is warranted. Cardiopulmonary bypass (CPB) may alter the pharmacokinetics of drugs in numerous ways. Since no such data exist, the aim of this study was to assess the serum concentrations and pharmacokinetics of moxifloxacin in patients undergoing cardiac surgery with CPB. Fourteen coronary artery bypass graft surgery patients received an intravenous infusion of 400 mg moxifloxacin as peri-operative antibiotic prophylaxis. At 15 time points throughout a 24-h period, serum samples were obtained to measure moxifloxacin concentrations using high-performance liquid chromatography. In addition, a non-compartmental pharmacokinetic analysis, i.e. area under the concentration-time curve (AUC), volume of distribution at steady state (V(SS)), drug clearance (CL), elimination half-life (t(1/2)) and mean residence time (MRT), was performed in five patients. Apart from a slight transient decrease in moxifloxacin concentration at the onset, CPB did not affect the concentration-time curve. Mean ± standard deviation maximum drug concentration (C(max)) (5.12 ± 1.58 μg/mL), AUC (36.5 ± 5.40 μgh/mL), VSS (2.03 ± 0.30 L/kg), CL (11.2 ± 1.91 L/h), t(1/2) (9.47 ± 0.92 h) and MRT (12.9 ± 1.52 h) were comparable with historical data for healthy volunteers. We conclude that CPB does not alter the pharmacokinetics of moxifloxacin. No dose adjustments, especially with regard to the CPB circuit and its priming volume, are necessary in cardiac surgical patients.

authors

Wiesner G,Martin K,Gertler R,Braun SL,Tassani P,Lange R,Gruber M

doi

10.1016/j.ijantimicag.2013.01.017

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

473-6

issue

5

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(13)00044-7

journal_volume

41

pub_type

杂志文章
  • Conclusions: the future of antimicrobial therapy - Augmentin and beyond.

    abstract::Since most infectious microorganisms inevitably develop resistance to any agents used to combat them, there has been a constant need to produce improved, more potent, antimicrobials. At least in part, the emergence and spread of resistant organisms has been provoked by inappropriate over-use of antibacterials. In the ...

    journal_title:International journal of antimicrobial agents

    pub_type: 历史文章,杂志文章,评审

    doi:10.1016/j.ijantimicag.2007.08.016

    authors: Ball P

    更新日期:2007-12-01 00:00:00

  • Teicoplanin for treating enterococcal infective endocarditis: A retrospective observational study from a referral centre in Spain.

    abstract::This study aimed to evaluate the effectiveness and safety of teicoplanin for treating enterococcal infective endocarditis (EIE). A retrospective analysis of a prospective cohort of definite EIE patients treated with teicoplanin in a Spanish referral centre (2000-2017) was performed. The primary outcome was mortality d...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2018.10.003

    authors: Escolà-Vergé L,Fernández-Hidalgo N,Rodríguez-Pardo D,Pigrau C,González-López JJ,Bartolomé R,Almirante B

    更新日期:2019-02-01 00:00:00

  • Effect of the antimicrobial decapeptide KSL on the growth of oral pathogens and Streptococcus mutans biofilm.

    abstract::Dental caries and periodontitis are common oral bacterial infectious diseases. Their prevention and treatment requires control of the causative pathogens, such as Streptococcus mutans and Porphyromonas gingivalis, that exist within dental plaque. As one of the attractive future substitutes for conventional antibiotics...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2010.08.014

    authors: Liu Y,Wang L,Zhou X,Hu S,Zhang S,Wu H

    更新日期:2011-01-01 00:00:00

  • Green tea inhibits Helicobacter growth in vivo and in vitro.

    abstract::Helicobacter infection, one of the most common bacterial infections in man worldwide, is a type 1 carcinogen and the most important risk factor for gastric cancer. Helicobacter pylori bacterial factors, components of the host genetics and immune response, dietary cofactors and decreased acid secretion resulting in bac...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2008.10.032

    authors: Stoicov C,Saffari R,Houghton J

    更新日期:2009-05-01 00:00:00

  • Is it possible to achieve bacterial eradication in otitis media with effusion by empirical antibiotic high doses and concomitant administration of acetaminophen? A microbiological and pharmacological study in the gerbil model.

    abstract::The efficacy of amoxycillin-clavulanic acid (10 and 15 mg/kg amoxycillin) and erythromycin (20 and 50 mg/kg) was assessed in a gerbil model of otitis media with effusion induced by beta-lactamase-producing Haemophilus influenzae. Animals were divided into groups receiving acetaminophen concomitantly or not receiving i...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/s0924-8579(03)00148-1

    authors: Parra A,Ponte C,Cenjor C,García-Olmos M,Giménez MJ,Aguilar L,Soriano F

    更新日期:2003-11-01 00:00:00

  • Ex vivo efficacy of gemifloxacin in experimental keratitis induced by methicillin-resistant Staphylococcus aureus.

    abstract::In recent years, the emergence of methicillin-resistant Staphylococcus aureus (MRSA) strains has been observed in ocular infections. Resistance of MRSA to second- and third-generation fluoroquinolones has increased interest in the fourth-generation fluoroquinolones. In this study, the antibacterial activity of gemiflo...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2016.06.026

    authors: Marino A,Blanco AR,Ginestra G,Nostro A,Bisignano G

    更新日期:2016-10-01 00:00:00

  • suPAR: The unspecific marker for disease presence, severity and prognosis.

    abstract::Investigation of biomarkers that can promptly predict unfavourable outcome of critically illness is an emerging necessity taking into consideration the need for early intervention, the shortage of available beds in intensive care units and the considerable cost of hospitalisation. The most promising biomarker is solub...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2015.10.011

    authors: Eugen-Olsen J,Giamarellos-Bourboulis EJ

    更新日期:2015-12-01 00:00:00

  • Combined treatment of Pseudomonas aeruginosa biofilm with lactoferrin and xylitol inhibits the ability of bacteria to respond to damage resulting from lactoferrin iron chelation.

    abstract::With an ageing and ever more obese population, chronic wounds such as diabetic ulcers, pressure ulcers and venous leg ulcers are an increasingly relevant medical concern. Identification of bacterial biofilm contamination as a major contributor to non-healing wounds demands biofilm-targeted strategies to manage chronic...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2010.12.019

    authors: Ammons MC,Ward LS,Dowd S,James GA

    更新日期:2011-04-01 00:00:00

  • Molecular characterisation of cyp51A and cyp51B genes coding for P450 14alpha-lanosterol demethylases A (CYP51Ap) and B (CYP51Bp) from voriconazole-resistant laboratory isolates of Aspergillus flavus.

    abstract::Aspergillus flavus is the second most common Aspergillus spp. causing invasive infections in immunocompromised patients. Extensive prophylactic use of voriconazole (VCZ) in immunocompromised patients may enhance the selection of VCZ-resistant clinical isolates of A. flavus, compromising the effectiveness of this antif...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2008.06.018

    authors: Krishnan-Natesan S,Chandrasekar PH,Alangaden GJ,Manavathu EK

    更新日期:2008-12-01 00:00:00

  • Skin and soft tissue infection: microbiology and epidemiology.

    abstract::Skin and soft tissue infections (SSTIs) are common and range in severity from minor, self-limiting, superficial infections to life-threatening diseases requiring all the resources of modern medicine. The classification of SSTIs can be based on the anatomical site, clinical severity or microbial cause, but some classif...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/S0924-8579(09)70541-2

    authors: Dryden MS

    更新日期:2009-07-01 00:00:00

  • In vitro susceptibility of cultured human methanogens to lovastatin.

    abstract::Lovastatin is a prodrug that is hydrolysed in vivo to β-hydroxy acid lovastatin, which inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-Co-A) reductase (HMGR), thereby lowering cholesterol in humans. A side effect of lovastatin is inhibition of isoprenoid synthesis and cell membrane formation in methanogenic Archae...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2016.09.026

    authors: Demonfort Nkamga V,Armstrong N,Drancourt M

    更新日期:2017-02-01 00:00:00

  • Moxifloxacin is non-inferior to combination therapy with ceftriaxone plus metronidazole in patients with community-origin complicated intra-abdominal infections.

    abstract::Management of community-origin complicated intra-abdominal infections (cIAIs) requires surgical intervention and antimicrobial therapy. This multinational, randomised, double-blind clinical trial carried out in Asia compared the efficacy and safety of moxifloxacin monotherapy and ceftriaxone/metronidazole combination ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ijantimicag.2009.06.022

    authors: Solomkin J,Zhao YP,Ma EL,Chen MJ,Hampel B,DRAGON Study Team.

    更新日期:2009-11-01 00:00:00

  • Combination therapy with polymyxin B for carbapenemase-producing Klebsiella pneumoniae bloodstream infection.

    abstract::Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) bloodstream infections (BSIs) are related to high mortality rates, and combination therapy has been associated with lower mortality in patients treated mostly with colistin. There is a paucity of studies addressing polymyxin B (PMB) treatment for KPC...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2018.10.010

    authors: Medeiros GS,Rigatto MH,Falci DR,Zavascki AP

    更新日期:2019-02-01 00:00:00

  • In-vitro development of an effective treatment for Acanthamoeba keratitis.

    abstract::The aim of this study was to develop an in-vitro topical treatment for Acanthamoeba keratitis (AK) effective against cysts and trophozoites. Qualitative assays were performed with voriconazole, chlorhexidine, propamidine, cellulase, tobramycin, ciprofloxacin and paromomycin as monotherapy and various combinations. Rib...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2017.03.033

    authors: Ortillés Á,Belloc J,Rubio E,Fernández MT,Benito M,Cristóbal JÁ,Calvo B,Goñi P

    更新日期:2017-09-01 00:00:00

  • Meta-analysis and systematic review of the efficacy and resistance for human immunodeficiency virus type 1 integrase strand transfer inhibitors.

    abstract::Integrase strand transfer inhibitors (INSTIs) are the most recent class of antiretroviral drugs with potent and durable antiviral activity used to treat human immunodeficiency virus type 1 (HIV-1) infection. However, development of drug resistance increases the risk of treatment failure, disease progression and mortal...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ijantimicag.2019.08.008

    authors: Yang LL,Li Q,Zhou LB,Chen SQ

    更新日期:2019-11-01 00:00:00

  • Relationship between susceptibility to antimicrobials and virulence factors in paediatric Escherichia coli isolates.

    abstract::The in vitro susceptibilities to several antibiotics of 136 Escherichia coli strains containing virulence factors isolated from children with urinary tract infection were analysed. Escherichia coli strains were analysed by multiplex polymerase chain reaction for genes encoding the following virulence factors: pyelonep...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2007.07.030

    authors: Arisoy M,Rad AY,Akin A,Akar N

    更新日期:2008-02-01 00:00:00

  • Trends in antimicrobial susceptibility of bacterial pathogens isolated from patients with bloodstream infections in the USA, Canada and Latin America. SENTRY Participants Group.

    abstract::From January through June of 1998, 4579 bloodstream infections (BSI) due to bacterial pathogens were reported from SENTRY hospitals in Canada, the USA and Latin America. Staphylococcus aureus, Escherichia coli, and coagulase-negative staphylococcus (CoNS) were the most common pathogens, together accounting for 55.2% o...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/s0924-8579(99)00131-4

    authors: Diekema DJ,Pfaller MA,Jones RN,Doern GV,Kugler KC,Beach ML,Sader HS

    更新日期:2000-02-01 00:00:00

  • Novel anti-microbial therapies for dental plaque-related diseases.

    abstract::Control of dental plaque-related diseases has traditionally relied on non-specific removal of plaque by mechanical means. As our knowledge of oral disease mechanisms increases, future treatment is likely to be more targeted, for example at small groups of organisms, single species or at key virulence factors they prod...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2008.07.014

    authors: Allaker RP,Douglas CW

    更新日期:2009-01-01 00:00:00

  • High rates of off-label use in antibiotic prescriptions in a context of dramatic resistance increase: a prospective study in a tertiary hospital.

    abstract::The use of antibiotics, as any other drug, is regulated by the terms of its marketing authorisation, notified in the Summary of Product Characteristics (SPC). If a prescription is not in accordance with the SPC, the physician prescribes off-label. There is very little literature regarding off-label use of antibiotics ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2016.04.010

    authors: Davido B,Bouchand F,Calin R,Makhloufi S,Lagrange A,Senard O,Perronne C,Villart M,Salomon J,Dinh A

    更新日期:2016-06-01 00:00:00

  • Acute kidney injury risk associated with piperacillin/tazobactam compared with cefepime during vancomycin therapy in hospitalised patients: a cohort study stratified by baseline kidney function.

    abstract::Recent studies have found an association between piperacillin/tazobactam when added to vancomycin and acute kidney injury (AKI) risk. However, studies were limited by the small sample size and residual confounding. The aim of this study was to compare the risk of AKI with vancomycin plus piperacillin/tazobactam (VPT) ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2017.02.023

    authors: Jeon N,Staley B,Klinker KP,Hincapie Castillo J,Winterstein AG

    更新日期:2017-07-01 00:00:00

  • Do antibacterial and antifungal combinations have better activity against clinically relevant fusarium species? in vitro synergism.

    abstract::The aim of this study was to evaluate the susceptibility of 20 clinical isolates of Fusarium spp. to classic antifungals [amphotericin B (AmB), itraconazole (ITR), voriconazole (VRC) and caspofungin (CAS)] and to non-antifungal agents [amiodarone (AMD), doxycycline (DOX) and moxifloxacin (MFX)] by the broth microdilut...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2017.10.017

    authors: Venturini TP,Al-Hatmi AMS,Rossato L,Azevedo MI,Keller JT,Weiblen C,Santurio JM,Alves SH

    更新日期:2018-05-01 00:00:00

  • In vitro activities of fourteen antimicrobial agents against obligately anaerobic bacteria.

    abstract::The in vitro activities of fourteen antimicrobial agents were tested against 292 clinical isolates of obligately anaerobic bacteria using the broth microdilution technique. Taking all strains as a group the MIC(50/90) (mg/l) values were metronidazole and imipenem 0.25/1, meropenem 0.25/0.5, trovafloxacin 0.25/1, gatif...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/s0924-8579(00)00186-2

    authors: Schaumann R,Ackermann G,Pless B,Claros MC,Goldstein EJ,Rodloff AC

    更新日期:2000-11-01 00:00:00

  • Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis.

    abstract::This study aimed to investigate whether fluid shifts alter ciprofloxacin pharmacokinetics in critically ill patients over time. Patients > or = 18 years, with normal renal function, requiring intensive care treatment and parenteral antibiotics were enrolled. Group A (22 patients) included patients with documented intr...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2005.04.005

    authors: Gous A,Lipman J,Scribante J,Tshukutsoane S,Hon H,Pinder M,Mathivha R,Verhoef L,Stass H

    更新日期:2005-07-01 00:00:00

  • Do raspberry extracts and fractions have antifungal or anti-adherent potential against Candida spp.?

    abstract::Candida spp., especially Candida albicans, is one of the main colonisers of the oral cavity. Due to its ability to form biofilms, it can be implicated in dental caries, periodontal disease and denture stomatitis. Microbial cells in biofilms are minimally impacted by conventional drugs. The aim of this study was to fin...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2018.08.020

    authors: Dutreix L,Bernard C,Juin C,Imbert C,Girardot M

    更新日期:2018-12-01 00:00:00

  • The changing epidemiology of invasive fungal infections: new threats.

    abstract::The epidemiology of invasive fungal infections is currently at a crucial stage. Potentially fatal fungal strains are emerging that are resistant to many commonly used antifungal agents. It is therefore important to recognize and minimize the major risk factors associated with infection. This paper summarizes the key e...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2006.03.006

    authors: Maschmeyer G

    更新日期:2006-06-01 00:00:00

  • Whole-genome analysis of an extensively drug-resistant clinical isolate of Acinetobacter baumannii AC12: insights into the mechanisms of resistance of an ST195 clone from Malaysia.

    abstract::Acinetobacter baumannii has emerged as an important nosocomial pathogen owing to its increasing resistance to most, if not all, antibiotics in clinical use. We recently reported the occurrence of extensively drug-resistant (XDR) A. baumannii isolates in a Malaysian tertiary hospital. The genome of one of these XDR iso...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2014.10.015

    authors: Lean SS,Yeo CC,Suhaili Z,Thong KL

    更新日期:2015-02-01 00:00:00

  • Geographically-based evaluation of multidrug resistance trends among Streptococcus pneumoniae in the USA: findings of the FAST surveillance initiative (2003-2004).

    abstract::Surveillance initiatives to track Streptococcus pneumoniae resistance trends are important for understanding the current in vitro effectiveness of available antimicrobial agents. The antimicrobial susceptibility profiles of S. pneumoniae (n=1479 isolates) collected from 17 geographical areas across the USA (2003-2004)...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2006.09.002

    authors: Draghi DC,Jones ME,Sahm DF,Tillotson GS

    更新日期:2006-12-01 00:00:00

  • Increasing nosocomial infections of methicillin-resistant Staphylococcus aureus at a teaching hospital in Taiwan.

    abstract::Methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide important pathogen in nosocomial infections. To investigate the extent of the problem in Taiwan, analysis for the period of 1981-1994 was carried out of prospective surveillance data from the National Taiwan University Hospital, a major university teach...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/s0924-8579(96)00360-3

    authors: Chang SC,Sun CC,Yang LS,Luh KT,Hsieh WC

    更新日期:1997-03-01 00:00:00

  • Biomarkers as a guide for antimicrobial therapy.

    abstract::The use of biomarkers might help to avoid antibiotic misuse and overuse and to curb the rising incidence of microbial resistance. Amongst >100 biomarkers proposed for use as infection/sepsis markers, procalcitonin is the most frequently evaluated. It has been tested in 11 randomised controlled trials with more than 35...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2010.11.009

    authors: Reinhart K,Hartog CS

    更新日期:2010-12-01 00:00:00

  • Synthesis, antimicrobial activity and toxicity to nematodes of cyclam derivatives.

    abstract::The antimicrobial activity and toxicity to nematodes of the cyclam salt [H2{H2(4-CF3PhCH2)2Cyclam}](CH3COO)2⋅(CH3COOH)2 were evaluated. Estimated minimum inhibitory concentrations (MICs) of 9, 261 and 15 µg/mL were obtained for Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, respectively. For selec...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2017.03.002

    authors: Alves LG,Pinheiro PF,Feliciano JR,Dâmaso DP,Leitão JH,Martins AM

    更新日期:2017-05-01 00:00:00