当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS期刊下所有文献 > Ofloxacin and fleroxacin enhance superoxide production in human polymorphonuclear leukocytes by increasing phosphorylation in the signal transduction pathway.

Ofloxacin and fleroxacin enhance superoxide production in human polymorphonuclear leukocytes by increasing phosphorylation in the signal transduction pathway.

Abstract：

:Many antimicrobial agents including new quinolones (NQs) influence the cellular defense mechanisms such as polymorphonuclear leukocytes (PMNs), macrophages and lymphocytes. We examined the effects of NQs on superoxide (SO) production of PMNs following stimulation of phorbol myristate acetate (PMA). Ofloxacin (OFLX) and fleroxacin (FLRX) significantly augmented SO production of PMNs compared to lomefloxacin, sparfloxacin. Staurosporin and H-7, specific inhibitors of protein kinase C of SO production pathway in PMNs, inhibited augmented SO production by OFLX and FLRX in the concentration-dependent manner. NADPH oxidase activity was not influenced by OFLX in cell lysate assay system. These results suggest that OFLX and FLRX augmented PMN function through enhancing protein kinase activity, but not through direct enhancement of NADPH oxidase.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Matsumoto T,Nagafuji T,Takahashi K,Kubo S,Sakumoto M,Mizunoe Y,Kumazawa J

doi

10.1016/0924-8579(95)00024-0

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

85-9

issue

2

eissn

0924-8579

issn

1872-7913

pii

0924-8579(95)00024-0

journal_volume

6

pub_type

杂志文章

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