Abstract：
:This study evaluated the activity of colistin, rifampicin, imipenem and sulbactam/ampicillin alone or in combination against nine epidemic multidrug-resistant Acinetobacter baumannii isolates producing OXA-58 carbapenemase in Naples, Italy. The isolates were susceptible to colistin but differed in their resistance to imipenem and rifampicin. Time-kill studies showed a bactericidal effect for colistin but not for imipenem, rifampicin or sulbactam/ampicillin used as single agents. Synergism was observed with combinations of rifampicin+imipenem or sulbactam/ampicillin for all isolates and with colistin+rifampicin for isolates showing higher minimum inhibitory concentrations for rifampicin. Combined use of the antimicrobials tested may provide good therapeutic options for OXA-58 carbapenemase-producing A. baumannii infections.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Tripodi MF,Durante-Mangoni E,Fortunato R,Utili R,Zarrilli Rdoi
10.1016/j.ijantimicag.2007.07.007subject
Has Abstractpub_date
2007-12-01 00:00:00pages
537-40issue
6eissn
0924-8579issn
1872-7913pii
S0924-8579(07)00321-4journal_volume
30pub_type
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