当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS期刊下所有文献 > Antibacterial activity of high concentrations of carvedilol against Gram-positive and Gram-negative bacteria.

Antibacterial activity of high concentrations of carvedilol against Gram-positive and Gram-negative bacteria.

Abstract：

:Many drugs used to treat non-infectious diseases have also shown excellent antibacterial activity or the ability to enhance the action of antibiotics. The aim of this study was to investigate the antibacterial activity of a popular β-blocker, carvedilol, and its mechanism of antibacterial action. The antibacterial activity of carvedilol was evaluated using the microdilution method and its influence on the viability of bacterial cells was investigated by the alamarBlue® test. Changes in phospholipid and fatty acid composition were analysed using LC-MS/MS and GC-MS techniques. The permeability of bacterial cell membranes following exposure to carvedilol was studied using propidium iodide staining and confocal microscopy. The ability of the tested bacteria to degrade carvedilol was examined by LC-MS/MS. In this study, the antibacterial activity of carvedilol is described for the first time, with a decrease in the viability of all assayed bacteria observed following treatment with the β-blocker. Staphylococcus aureus and Staphylococcus epidermidis were found to be the most sensitive among the tested strains. Significant modifications to fatty acid composition were observed in S. aureus incubated with carvedilol. Moreover, the cell membrane permeability of bacteria incubated with carvedilol was higher for Gram-positive bacteria than for Gram-negative bacteria. Furthermore, Gram-negative Escherichia coli and Pseudomonas aeruginosa strains, which were highly resistant to carvedilol, exhibited an ability to eliminate carvedilol from the growth medium. In addition, three carvedilol metabolites were identified in E. coli and P. aeruginosa cultures. The antibacterial activity of carvedilol may suggest its potential usefulness in the synthesis of new antibacterial drugs.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Zawadzka K,Bernat P,Felczak A,Różalska S,Lisowska K

doi

10.1016/j.ijantimicag.2017.12.014

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

458-467

issue

3

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(17)30448-X

journal_volume

51

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS文献大全
  • Activity of combinations of ceftazidime, imipenem and pefloxacin against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.

    abstract：:The chequerboard technique was used to look for synergistic combinations of ceftazidime, imipenem and pefloxacin. The synergistic combinations were used in vivo in mice experimentally infected with Escherichia coli, Salmonella typhimurium and Pseudomonas aeruginosa. In vitro ceftazidime/imipenem, ceftazidime/pefloxaci...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(03)00127-4

    authors： El-Sukhon SN,Faiza Boukhatem Z

    更新日期：2003-12-01 00:00:00

  • Discontinuation of antibiotic therapy within 24 hours of treatment initiation for patients with no clinical evidence of bacterial infection: a 5-year safety and outcome study from Singapore General Hospital Antimicrobial Stewardship Program.

    abstract：BACKGROUND:Overprescribing antibiotics for patients with no bacterial infection is of growing global concern. It is important for timely Antimicrobial Stewardship Program (ASP) intervention to discontinue antibiotics for patients whose symptoms can be explained by non-infective causes, and without availability of bacte...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.01.008

    authors： Loo LW,Liew YX,Lee W,Lee LW,Chlebicki P,Kwa AL

    更新日期：2019-05-01 00:00:00

  • Effect of the antimicrobial decapeptide KSL on the growth of oral pathogens and Streptococcus mutans biofilm.

    abstract：:Dental caries and periodontitis are common oral bacterial infectious diseases. Their prevention and treatment requires control of the causative pathogens, such as Streptococcus mutans and Porphyromonas gingivalis, that exist within dental plaque. As one of the attractive future substitutes for conventional antibiotics...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2010.08.014

    authors： Liu Y,Wang L,Zhou X,Hu S,Zhang S,Wu H

    更新日期：2011-01-01 00:00:00

  • Therapeutic potential of dalbavancin in a rat model of methicillin-resistant Staphylococcus aureus (MRSA)-osteomyelitis.

    abstract：:Bacterial osteomyelitis is a major clinical challenge in human and veterinary patients. This infection is an infrequent but feared complication of orthopedic surgery and is mainly caused by methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to evaluate the efficacy of dalbavancin (dosed for ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.106021

    authors： Silva V,Miranda C,Antão HS,Guimarães J,Prada J,Pires I,Maltez L,Pereira JE,Capelo JL,Igrejas G,Poeta P

    更新日期：2020-07-01 00:00:00

  • Invasive group A streptococcal infection: New concepts in antibiotic treatment.

    abstract：:The incidence of severe group A streptococcal infection and the streptococcal toxic shock syndrome has increased since 1986. In contrast to earlier times, aggressive streptococal infection is now more likely to affect patients between 20 and 50 years of age who do not have predisposing underlying diseases. Its viral-l...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/0924-8579(94)90029-9

    authors： Stevens DL,Bryant AE,Yan S

    更新日期：1994-01-01 00:00:00

  • Five-year trends for ventilator-associated pneumonia: Correlation between microbiological findings and antimicrobial drug consumption.

    abstract：:The epidemiology of multidrug-resistant bacteria (MDRB) has changed significantly in European healthcare settings, with a decrease in frequency of meticillin-resistant Staphylococcus aureus and an increase in extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. Little is known about the effects of these ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2015.07.010

    authors： Fihman V,Messika J,Hajage D,Tournier V,Gaudry S,Magdoud F,Barnaud G,Billard-Pomares T,Branger C,Dreyfuss D,Ricard JD

    更新日期：2015-11-01 00:00:00

  • Evaluation of the efficacy and safety of ceftazidime/avibactam in the treatment of Gram-negative bacterial infections: a systematic review and meta-analysis.

    abstract：:Data on the efficacy and safety of ceftazidime/avibactam (CAZ-AVI) are limited. A systematic review and meta-analysis was conducted to clarify the role of CAZ-AVI for patients with serious Gram-negative bacterial infections. The PubMed, EMBASE and Cochrane Library databases were searched for randomised controlled tria...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ijantimicag.2018.07.004

    authors： Zhong H,Zhao XY,Zhang ZL,Gu ZC,Zhang C,Gao Y,Cui M

    更新日期：2018-10-01 00:00:00

  • Antimicrobial susceptibilities of Pasteurella strains isolated from humans.

    abstract：:The in vitro susceptibilities of 192 consecutive clinical strains of Pasteurella spp. isolated between 1996 and 2003 from soft tissue pus (n = 146), respiratory tract specimens (n = 38) and blood (n = 8) were studied by an agar dilution method. All isolates were susceptible to minocycline, cefotaxime, ofloxacin, cipro...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.02.004

    authors： Lion C,Conroy MC,Carpentier AM,Lozniewski A

    更新日期：2006-04-01 00:00:00

  • Current challenges in the diagnosis and management of invasive fungal infections: report from the 15th International Symposium on Infections in the Immunocompromised Host: Thessaloniki, Greece, 22-25 June 2008.

    abstract：:New, aggressive forms of immunosuppression and an increasing population of patients at risk provide fertile ground for opportunistic invasive fungal infections (IFIs). Particularly challenging is the changing epidemiology of IFIs: rare pathogens are now more common and resistant strains are emerging among species that...

    journal_title：International journal of antimicrobial agents

    pub_type：

    doi：10.1016/j.ijantimicag.2008.08.014

    authors： Groll AH,McNeil Grist L

    更新日期：2009-02-01 00:00:00

  • In vitro activity of sitafloxacin compared with several fluoroquinolones against Streptococcus anginosus and Streptococcus constellatus.

    abstract：:The in vitro activities of sitafloxacin and seven other fluoroquinolones a (ciprofloxacin, tosufloxacin, sparfloxacin, levofloxacin, T-3811ME, moxifloxacin and trovafloxacin) were examined by the microdilution method against 79 clinically isolated 'Streptococcus milleri' group (SMG) microorganisms. No statistically si...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2005.10.006

    authors： Yamamoto N,Fujita J,Shinzato T,Higa F,Tateyama M,Tohyama M,Nakasone I,Yamane N

    更新日期：2006-02-01 00:00:00

  • Antimicrobial drug resistance mechanisms among Mollicutes.

    abstract：:Representatives of the Mollicutes class are the smallest, wall-less bacteria capable of independent reproduction. They are widespread in nature, most are commensals, and some are pathogens of humans, animals and plants. They are also the main contaminants of cell cultures and vaccine preparations. Despite limited bios...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2020.106253

    authors： Chernova OA,Chernov VM,Mouzykantov AA,Baranova NB,Edelstein IA,Aminov RI

    更新日期：2020-11-29 00:00:00

  • Nosocomial pneumonia: importance of recognition of aetiological agents to define an appropriate initial empirical therapy.

    abstract：:Of the 16,024 patients hospitalized from January 1995 to October 1997, 397 (2.4%) acquired nosocomial pneumonia and the aetiological agent was defined in 101 (25%). About 82% developed late onset pneumonia (>7 days of hospitalization). The site of isolation of microorganisms was bronchoalveolar lavage (BAL) (49%), blo...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(00)00316-2

    authors： Costa SF,Newbaer M,Santos CR,Basso M,Soares I,Levin AS

    更新日期：2001-02-01 00:00:00

  • Does consistent piperacillin dosing result in consistent therapeutic concentrations in critically ill patients? A longitudinal study over an entire antibiotic course.

    abstract：:Piperacillin plasma concentrations are known to vary between critically ill patients. However, there are no comprehensive data on the variability of antibiotic concentrations within the same patient. The purpose of this study was to investigate the adequacy of dosing during an entire 7-day antibiotic course and to inv...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2014.01.028

    authors： Carlier M,Carrette S,Stove V,Verstraete AG,De Waele JJ

    更新日期：2014-05-01 00:00:00

  • The burden of invasive pneumococcal disease and the potential for reduction by immunisation.

    abstract：:Streptococcus pneumoniae causes invasive disease world-wide and in all age groups. The reported incidence varies geographically and is increased in certain population groups. The incidence is highest in children less than 2 years and is also increased in the elderly. Mortality remains substantial even in the developed...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/s0924-8579(01)00491-5

    authors： Parsons HK,Dockrell DH

    更新日期：2002-02-01 00:00:00

  • Susceptibility of lactic acid bacteria, bifidobacteria and other bacteria of intestinal origin to chemotherapeutic agents.

    abstract：:Chemotherapy is a cornerstone of cancer treatment but it can have serious side effects, such as intestinal mucositis. This work reports the susceptibility/resistance profiles of 34 species of lactic acid bacteria (LAB), bifidobacteria and other intestinal bacteria from different collections to various chemotherapeutic...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.07.011

    authors： Flórez AB,Sierra M,Ruas-Madiedo P,Mayo B

    更新日期：2016-11-01 00:00:00

  • Antiviral therapy of herpes simplex.

    abstract：:Herpes simplex virus (HSV) infections in immunocompromised patients are more severe and invasive than in non-immunocompromised patients. They are characterised by prolonged viral shedding and a tendency to heal more slowly. In addition, resistant viruses are exclusively isolated in immunocompromised patients, requirin...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/s0924-8579(00)00233-8

    authors： Snoeck R

    更新日期：2000-10-01 00:00:00

  • Outcomes of adjunctive therapy with intrathecal or intraventricular administration of colistin for post-neurosurgical meningitis and ventriculitis due to carbapenem-resistant acinetobacter baumannii.

    abstract：:The efficacy and safety of intrathecal (ITH) or intraventricular (IVT) colistin in addition to intravenous (IV) colistin for meningitis and ventriculitis due to carbapenem-resistant Acinetobacter baumannii (CRAB) is unclear. In this retrospective observational study of 40 patients with post-neurosurgical meningitis an...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.12.002

    authors： Chusri S,Sakarunchai I,Kositpantawong N,Panthuwong S,Santimaleeworagun W,Pattharachayakul S,Singkhamanan K,Doi Y

    更新日期：2018-04-01 00:00:00

  • Bacterial biofilm formation on urologic devices and heparin coating as preventive strategy.

    abstract：:In the process of endourological development a variety of foreign bodies have been invented besides urinary catheters, on which biofilm can be formed. Bacteria in the biofilm are less susceptible to antibiotics. An additional problem of medical biomaterials in the urinary tract environment is the development of encrus...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2003.12.007

    authors： Tenke P,Riedl CR,Jones GL,Williams GJ,Stickler D,Nagy E

    更新日期：2004-03-01 00:00:00

  • Outpatient parenteral antibiotic therapy (OPAT) in different countries: a comparison.

    abstract：:In order to assess how outpatient parenteral antibiotic therapy (OPAT) is managed in different countries, we analyzed the data collected in the USA, UK and Italy by the International OPAT Registry using an ad hoc Access/Excel Microsoft program. The analysis of data concerned 9826 patients in the USA, 981 in the UK and...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.06.004

    authors： Esposito S,Noviello S,Leone S,Tice A,Seibold G,Nathwani D,Scaglione F,International OPAT Registry.

    更新日期：2004-11-01 00:00:00

  • Subtleties in practical application of prolonged infusion of β-lactam antibiotics.

    abstract：:Prolonged infusion (PI) of β-lactam antibiotics is increasingly used in order to optimise antibiotic exposure in critically ill patients. Physicians are often not aware of a number of subtleties that may jeopardise the treatment. In this clinically based paper, we stress pragmatic issues, such as the importance of a l...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2015.01.007

    authors： De Waele JJ,Lipman J,Carlier M,Roberts JA

    更新日期：2015-05-01 00:00:00

  • Maternal and fetal blood levels of moxifloxacin, levofloxacin, cefepime and cefoperazone.

    abstract：:Wide-spectrum quinolones such as moxifloxacin and levofloxacin as well as high-order cephalosporins such as cefoperazone and cefepime have increased antimicrobial activity. However, little is known about their distribution in fetal blood. Therefore, the aim of this study was to measure and compare maternal and fetal b...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2010.03.011

    authors： Ozyuncu O,Nemutlu E,Katlan D,Kir S,Beksac MS

    更新日期：2010-08-01 00:00:00

  • Potent antiviral activity of brequinar against the emerging Cantagalo virus in cell culture.

    abstract：:In the present work, the antiviral activity of brequinar (BQR) against the replication of Cantagalo virus was evaluated. BQR is a potent inhibitor of cellular dihydroorotate dehydrogenase, an enzyme of the de novo pyrimidine biosynthetic pathway. Infection in the presence of 0.5μM BQR reduced virus progeny production ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2011.07.002

    authors： Schnellrath LC,Damaso CR

    更新日期：2011-11-01 00:00:00

  • In vitro prevention of Pseudomonas aeruginosa early biofilm formation with antibiotics used in cystic fibrosis patients.

    abstract：:The ability of antibiotics used in bronchopulmonary infections in cystic fibrosis (CF) patients to prevent Pseudomonas aeruginosa early biofilm formation was studied using a biofilm microtitre assay with 57 non-mucoid P. aeruginosa isolates (44 first colonisers and 13 recovered during the initial intermittent colonisa...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2012.04.006

    authors： Fernández-Olmos A,García-Castillo M,Maiz L,Lamas A,Baquero F,Cantón R

    更新日期：2012-08-01 00:00:00

  • Effect of drug concentration on adsorption of levofloxacin by polyacrylonitrile haemofilters.

    abstract：:We studied an in vitro model of continuous venovenous haemofiltration to determine levofloxacin adsorption by polyacrylonitrile (PAN) filters. Four doses of levofloxacin (5, 25, 50 and 100 mg) were used, resulting in circulating concentrations of levofloxacin at 120 min of 3.56+/-0.14, 15.84+/-2.08, 31.42+/-1.95 and 5...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.03.025

    authors： Tian Q,Gomersall CD,Wong A,Leung P,Choi G,Joynt GM,Tan P,Lipman J

    更新日期：2006-08-01 00:00:00

  • Chlorhexidine exposure of clinical Klebsiella pneumoniae strains leads to acquired resistance to this disinfectant and to colistin.

    abstract：:Chlorhexidine is widely used as a disinfectant in hospitals, which may impose a selective pressure on bacteria. This study aimed to determine whether continuous exposure to chlorhexidine could lead to adaptive resistance and cross-resistance as well as investigating potential resistance mechanisms. Three clinical Kleb...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.02.012

    authors： Zhang Y,Zhao Y,Xu C,Zhang X,Li J,Dong G,Cao J,Zhou T

    更新日期：2019-06-01 00:00:00

  • Skin and soft tissue infection: microbiology and epidemiology.

    abstract：:Skin and soft tissue infections (SSTIs) are common and range in severity from minor, self-limiting, superficial infections to life-threatening diseases requiring all the resources of modern medicine. The classification of SSTIs can be based on the anatomical site, clinical severity or microbial cause, but some classif...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/S0924-8579(09)70541-2

    authors： Dryden MS

    更新日期：2009-07-01 00:00:00

  • Antimicrobial drug resistance in Taiwan.

    abstract：:Antimicrobial resistance is a major health problem worldwide, but marked variations in the resistance profiles of bacterial pathogens are found between countries and in different patient settings, especially in Asia. In Taiwan, the strikingly high prevalence of resistance to macrolides and streptogramins in clinical i...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/S0924-8579(08)70023-2

    authors： Huang YT,Hsueh PR

    更新日期：2008-11-01 00:00:00

  • Ceftriaxone activity against Gram-positive and Gram-negative pathogens isolated in US clinical microbiology laboratories from 1996 to 2000: results from The Surveillance Network (TSN) Database-USA.

    abstract：:Ceftriaxone was introduced into clinical practice in the USA in 1985 and was the first extended-spectrum (third-generation) cephalosporin approved for once-daily treatment of patients with Gram-positive or Gram-negative infections. Review of ceftriaxone activity is important given its continued use since the mid-1980s...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(02)00010-9

    authors： Karlowsky JA,Jones ME,Mayfield DC,Thornsberry C,Sahm DF

    更新日期：2002-05-01 00:00:00

  • Clinical efficacy, cost analysis and patient acceptability of outpatient parenteral antibiotic therapy (OPAT): a decade of Sheffield (UK) OPAT service.

    abstract：:Outpatient parenteral antimicrobial therapy (OPAT) has evolved relatively slowly in the UK. This study describes the OPAT service based in a large UK teaching hospital in Sheffield, and examines the clinical efficacy, patient acceptability and costs saved over a 10-year period. Data on 3812 episodes of OPAT administer...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.03.016

    authors： Durojaiye OC,Bell H,Andrews D,Ntziora F,Cartwright K

    更新日期：2018-01-01 00:00:00

  • New approach to the management of Clostridium difficile infection: colonisation with non-toxigenic C. difficile during daily ampicillin or ceftriaxone administration.

    abstract：:Non-toxigenic strains of Clostridium difficile are highly effective in preventing toxigenic C. difficile infection in hamsters when given following a single dose of an antimicrobial agent. The goal of this study was to determine the ability of non-toxigenic C. difficile to colonise hamsters during administration of an...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/S0924-8579(09)70017-2

    authors： Merrigan MM,Sambol SP,Johnson S,Gerding DN

    更新日期：2009-03-01 00:00:00