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Mutant prevention concentration for ciprofloxacin and levofloxacin with Pseudomonas aeruginosa.

Abstract：

:The mutant prevention concentration (MPC) was determined by population analysis using six fluoroquinolone-susceptible isolates of Pseudomonas aeruginosa applied to fluoroquinolone-containing agar plates. The MPCs were 3 mg/L and 9.5 mg/L for ciprofloxacin and levofloxacin, respectively. At high concentrations of either compound, single-step gyrA resistance mutants were recovered. Using a modified method for estimating the MPC, 151 clinical isolates were surveyed. Modal MPCs were 2 mg/L and 8 mg/L, respectively, for ciprofloxacin and levofloxacin. Thus, ciprofloxacin is three to four times more active than levofloxacin against resistant mutant subpopulations. For individual isolates, the MPC correlated poorly with the minimum inhibitory concentration (r(2) = 0.41 and 0.39 for ciprofloxacin and levofloxacin, respectively).

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Hansen GT,Zhao X,Drlica K,Blondeau JM

doi

10.1016/j.ijantimicag.2005.10.005

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

120-4

issue

2

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(05)00323-7

journal_volume

27

pub_type

杂志文章

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