Characterisation of a multidrug-resistant Bacteroides fragilis isolate recovered from blood of a patient in Denmark using whole-genome sequencing.

abstract：:Clinafloxacin, levofloxacin, sparfloxacin and trovafloxacin were tested by Etest against 188 Streptococcus pneumoniae isolates. Clinafloxacin and trovafloxacin were 2-4-fold more potent than sparfloxacin and 8-fold more than levofloxacin. Two isolates, both serotype 6, with high-level quinolone resistance (> or = 8 mi...

journal_title：International journal of antimicrobial agents

authors： Waites K,Brookings E,Nix S,Robinson A,Gray B,Swiatlo E

更新日期：1998-02-01 00:00:00

abstract：:The tet(X) gene encodes a flavin-dependent monooxygenase that confers resistance to all clinically relevant tetracycline antibiotics including tigecycline. It has only previously been identified in environmental and non-human pathogenic bacteria. To investigate levels of multidrug resistance in Bo, Sierra Leone, a mol...

journal_title：International journal of antimicrobial agents

authors： Leski TA,Bangura U,Jimmy DH,Ansumana R,Lizewski SE,Stenger DA,Taitt CR,Vora GJ

更新日期：2013-07-01 00:00:00

abstract：:In December 2019, a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged from China causing pneumonia outbreaks, first in the Wuhan region of China and then spread worldwide because of its probable high transmission efficiency. Owing to the lack of efficient and specific treat...

journal_title：International journal of antimicrobial agents

authors： Baron SA,Devaux C,Colson P,Raoult D,Rolain JM

更新日期：2020-04-01 00:00:00

abstract：:Molecular epidemiology studies aiming at understanding the acquisition of antimicrobial resistance by clinical isolates of Klebsiella pneumoniae are regularly published; however, information on the genes that contribute to its characteristic phenotype of resistance to antibiotics (intrinsic resistome) is scarce. To fi...

journal_title：International journal of antimicrobial agents

authors： Bernardini A,Cuesta T,Tomás A,Bengoechea JA,Martínez JL,Sánchez MB

更新日期：2019-01-01 00:00:00

abstract：:The aim of this study was to investigate recurrent infections in individual patients caused by extended-spectrum β-lactamase and plasmid AmpC β-lactamase-producing Escherichia coli (ESBL/pAmpC-Ec) isolates with >12-month interval. The Danish national collection of ESBL/pAmpC-Ec isolates collected from January 2014 thr...

journal_title：International journal of antimicrobial agents

authors： Roer L,Hansen F,Hasman H,Hammerum AM,Cavaco LM

更新日期：2020-07-01 00:00:00

abstract：:This study was conducted to assess the clinical outcomes of bloodstream infections caused by extended-spectrum beta-lactamase-producing Escherichia coli. A total of 53 patients were included in the study. Forty-five patients (84.9%) received appropriate antibiotic therapy. Initial empirical treatment was appropriate i...

journal_title：International journal of antimicrobial agents

authors： Metan G,Zarakolu P,Cakir B,Hascelik G,Uzun O

更新日期：2005-09-01 00:00:00

abstract：:Fluoroquinolones (FQs) are highly effective for treating tularaemia, a zoonosis caused by Francisella tularensis, but failures and relapses remain common in patients with treatment delay or immunocompromised status. FQ-resistant strains of F. tularensis harboring mutations in the quinolone-resistance determining regio...

journal_title：International journal of antimicrobial agents

authors： Sutera V,Hoarau G,Renesto P,Caspar Y,Maurin M

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:We hypothesised that treatment with a tigecycline-based antimicrobial regimen for intra-abdominal infection (IAI) could be associated with lower rates of subsequent carbapenem-resistant Enterobacteriaceae (CRE) colonisation or Clostridium difficile infection (CDI) compared with a meropenem-based regimen. ME...

journal_title：International journal of antimicrobial agents

authors： Bartoletti M,Tedeschi S,Pascale R,Raumer L,Maraolo AE,Palmiero G,Tumietto F,Cristini F,Ambretti S,Giannella M,Lewis RE,Viale P

更新日期：2018-03-01 00:00:00

abstract：:Mutants with oxazolidinone MICs, 2- to 16-fold higher than those of parents, were selected from two of five clinical isolates of Enterococcus faecalis during exposure to AZD2563, but only at frequencies of ca. 10(-8). Resistance was not selected in Enterococcus faecium, Staphylococcus aureus or coagulase-negative stap...

journal_title：International journal of antimicrobial agents

authors： Stockdale MW,Tysall L,Johnson AP,Livermore DM,Woodford N

更新日期：2004-01-01 00:00:00

abstract：:In the process of endourological development a variety of foreign bodies have been invented besides urinary catheters, on which biofilm can be formed. Bacteria in the biofilm are less susceptible to antibiotics. An additional problem of medical biomaterials in the urinary tract environment is the development of encrus...

journal_title：International journal of antimicrobial agents

authors： Tenke P,Riedl CR,Jones GL,Williams GJ,Stickler D,Nagy E

更新日期：2004-03-01 00:00:00

abstract：:The international (non-USA) ZAAPS Program has accumulated 4 years of linezolid resistance surveillance results tracking infections caused by organisms with evolving resistance profiles. The major organism groups monitored were: Staphylococcus aureus and coagulase-negative staphylococci (including methicillin [oxacilli...

journal_title：International journal of antimicrobial agents

authors： Ross JE,Fritsche TR,Sader HS,Jones RN

更新日期：2007-03-01 00:00:00

abstract：:Non-toxigenic strains of Clostridium difficile are highly effective in preventing toxigenic C. difficile infection in hamsters when given following a single dose of an antimicrobial agent. The goal of this study was to determine the ability of non-toxigenic C. difficile to colonise hamsters during administration of an...

journal_title：International journal of antimicrobial agents

authors： Merrigan MM,Sambol SP,Johnson S,Gerding DN

更新日期：2009-03-01 00:00:00

abstract：:The proline-rich antimicrobial peptide oncocin is remarkably active in vitro against a number of important Gram-negative bacteria of concern to humans owing to their increasing resistance to antibiotics, i.e. Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacae) and non-fermenting speci...

journal_title：International journal of antimicrobial agents

authors： Knappe D,Kabankov N,Hoffmann R

更新日期：2011-02-01 00:00:00

abstract：:In this first multi-centre study in Scotland, 1028 consecutive Gram-negative and staphylococci strains were obtained from four major teaching hospitals. E. coli was the most common organism among both intensive care units (ICUs) (39%) and non-ICU strains (46.6%). The prevalence of antibiotic resistance among E. coli w...

journal_title：International journal of antimicrobial agents

authors： Shanahan PM,Thomson CJ,Miles RS,Old D,Hood J,Gould IM,Amyes SG

更新日期：1996-07-01 00:00:00

abstract：:The safety of all drugs is established by animal studies, administration to healthy volunteers and the observations during clinical studies to confirm efficacy. During these studies, patients are questioned about side-effects and extensive laboratory testing of blood and urine samples is performed. Despite these exten...

journal_title：International journal of antimicrobial agents

authors： Williams JD

更新日期：2001-01-01 00:00:00

abstract：:The pharmacokinetic/pharmacodynamic (PK/PD) index for the efficacy of linezolid is a 24-h area under the plasma drug concentration-time curve (AUC₂₄)/minimum inhibitory concentration (MIC) ratio of ≥100. The main adverse event associated with administration of linezolid is thrombocytopenia. Therefore, the aims of the ...

journal_title：International journal of antimicrobial agents

authors： Matsumoto K,Shigemi A,Takeshita A,Watanabe E,Yokoyama Y,Ikawa K,Morikawa N,Takeda Y

更新日期：2014-09-01 00:00:00

abstract：:Invasive aspergillosis of the central nervous system has a mortality rate exceeding 90%. We describe a 29-year-old woman with a medical history of chronic polyarthritis who developed a proven rhinocerebral Aspergillus fumigatus infection refractory to first-line treatment with liposomal amphotericin B. The patient res...

journal_title：International journal of antimicrobial agents

authors： Elter T,Sieniawski M,Gossmann A,Wickenhauser C,Schröder U,Seifert H,Kuchta J,Burhenne J,Riedel KD,Fätkenheuer G,Cornely OA

更新日期：2006-09-01 00:00:00

abstract：:Three pharmacokinetic/pharmacodynamic parameters--(i) the peak concentration to the minimum inhibitory concentration ratio (C(max)/MIC); (ii) the area under the concentration-time curve to MIC ratio (AUC(24h)/MIC); and (iii) the time the concentration exceeds the MIC (T>MIC)--are important predictors of the clinical e...

journal_title：International journal of antimicrobial agents

authors： Van Bambeke F,Tulkens PM

更新日期：2001-01-01 00:00:00

abstract：:There is strong evidence that self-monitoring and feedback are effective behaviour change techniques (BCTs) across a range of healthcare interventions and that their effectiveness is enhanced by goal setting and action planning. Here we report a summary of the update of a systematic review assessing the application of...

journal_title：International journal of antimicrobial agents

authors： Davey P,Peden C,Charani E,Marwick C,Michie S

更新日期：2015-03-01 00:00:00

abstract：:Resistant mutants of Ureaplasma parvum were selected by serial passages of a susceptible strain in subinhibitory concentrations of different macrolides and related antibiotics (erythromycin, azithromycin, josamycin, quinupristin, quinupristin/dalfopristin, pristinamycin and telithromycin). Mechanisms of resistance wer...

journal_title：International journal of antimicrobial agents

authors： Pereyre S,Métifiot M,Cazanave C,Renaudin H,Charron A,Bébéar C,Bébéar CM

更新日期：2007-02-01 00:00:00

abstract：UNLABELLED:Paper-based interventions have been shown to stimulate switching from intravenous (i.v.) to oral (p.o.) antibiotic therapies. Shorter i.v. durations are associated with a lower risk of iatrogenic infections as well as reduced workload and costs. The purpose of this study was to determine whether automated el...

journal_title：International journal of antimicrobial agents

authors： Beeler PE,Kuster SP,Eschmann E,Weber R,Blaser J

更新日期：2015-10-01 00:00:00

abstract：:The epidemiology of invasive fungal infections is currently at a crucial stage. Potentially fatal fungal strains are emerging that are resistant to many commonly used antifungal agents. It is therefore important to recognize and minimize the major risk factors associated with infection. This paper summarizes the key e...

journal_title：International journal of antimicrobial agents

authors： Maschmeyer G

更新日期：2006-06-01 00:00:00

abstract：:The antimicrobial activity of linezolid, a recently developed antibiotic agent active against Gram-positive bacteria, was tested against pathogens from three different collections. (1) Uropathogens from hospitalized urological patients (1990/1991) with complicated and/or hospital-acquired UTIs; Urologic Clinic, Hospit...

journal_title：International journal of antimicrobial agents

authors： Onda H,Wagenlehner FM,Lehn N,Naber KG

更新日期：2001-09-01 00:00:00

abstract：:Isolates of Streptococcus pneumoniae collected over the first 4 years of the PROTEKT study were tested for susceptibility to penicillin, azithromycin and telithromycin. A total of 20,750 isolates were collected from 39 countries. Penicillin non-susceptibility rates were stable over the study period; overall, 21.8% of ...

journal_title：International journal of antimicrobial agents

authors： Schito GC,Felmingham D

更新日期：2005-12-01 00:00:00

abstract：:In this study, the in vitro activity of tigecycline against 1140 enterococci collected from humans, food products, animals and the environment in Portugal (1996-2008) was analysed. Ten isolates (seven Enterococcus faecalis and three Enterococcus spp.) non-susceptible to tigecycline (minimum inhibitory concentrations o...

journal_title：International journal of antimicrobial agents

authors： Freitas AR,Novais C,Correia R,Monteiro M,Coque TM,Peixe L

更新日期：2011-08-01 00:00:00

abstract：:The incidence of severe group A streptococcal infection and the streptococcal toxic shock syndrome has increased since 1986. In contrast to earlier times, aggressive streptococal infection is now more likely to affect patients between 20 and 50 years of age who do not have predisposing underlying diseases. Its viral-l...

journal_title：International journal of antimicrobial agents

authors： Stevens DL,Bryant AE,Yan S

更新日期：1994-01-01 00:00:00

abstract：:Nationwide monitoring of antimicrobial resistance in Campylobacter isolated from food-producing animals on farms was performed in Japan. A total of 468 Campylobacter isolates were obtained during the period from June 1999 to March 2001. Campylobacter species showed high frequencies of resistance to oxytetracycline and...

journal_title：International journal of antimicrobial agents

authors： Ishihara K,Kira T,Ogikubo K,Morioka A,Kojima A,Kijima-Tanaka M,Takahashi T,Tamura Y

更新日期：2004-09-01 00:00:00

abstract：:The ability of antibiotics used in bronchopulmonary infections in cystic fibrosis (CF) patients to prevent Pseudomonas aeruginosa early biofilm formation was studied using a biofilm microtitre assay with 57 non-mucoid P. aeruginosa isolates (44 first colonisers and 13 recovered during the initial intermittent colonisa...

journal_title：International journal of antimicrobial agents

authors： Fernández-Olmos A,García-Castillo M,Maiz L,Lamas A,Baquero F,Cantón R

更新日期：2012-08-01 00:00:00

abstract：:Mechanisms leading to carbapenem and cephalosporin resistance were sought in Enterobacter aerogenes isolates that were highly resistant to carbapenems but had no known carbapenemase. Results were compared with recent work examining carbapenem-resistant Enterobacter cloacae. Eighteen carbapenem-resistant E. aerogenes w...

journal_title：International journal of antimicrobial agents

authors： Babouee Flury B,Ellington MJ,Hopkins KL,Turton JF,Doumith M,Woodford N

更新日期：2016-11-01 00:00:00

abstract：:The in vitro activities of cefixime, a new third-generation cephalosporin, and of 18 other antimicrobial agents against 18 strains of Helicobacter pylori were determined. The strains of H. pylori were isolated from gastric biopsy specimens and tested for sensitivity to antibiotics by an agar dilution technique under m...

journal_title：International journal of antimicrobial agents

authors： Fera MT,Carbone M,Focà A

更新日期：1993-01-01 00:00:00