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Susceptibility of Streptococcus pneumoniae to penicillin, azithromycin and telithromycin (PROTEKT 1999-2003).

Abstract：

:Isolates of Streptococcus pneumoniae collected over the first 4 years of the PROTEKT study were tested for susceptibility to penicillin, azithromycin and telithromycin. A total of 20,750 isolates were collected from 39 countries. Penicillin non-susceptibility rates were stable over the study period; overall, 21.8% of isolates were resistant. Azithromycin resistance increased from 31.0% in Year 1 to 36.3% in Year 4. Resistance rates for penicillin and azithromycin varied between countries and were highest in France, Spain, South Africa, USA and the Far East. Multidrug resistance in S. pneumoniae did not change significantly over the 4 years, with an overall rate of 38.6%. Telithromycin retained good activity against S. pneumoniae (0.1% of isolates resistant), including multidrug-resistant isolates.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Schito GC,Felmingham D

doi

10.1016/j.ijantimicag.2005.04.022

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

479-85

issue

6

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(05)00260-8

journal_volume

26

pub_type

杂志文章,多中心研究

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