Abstract：
:The tet(X) gene encodes a flavin-dependent monooxygenase that confers resistance to all clinically relevant tetracycline antibiotics including tigecycline. It has only previously been identified in environmental and non-human pathogenic bacteria. To investigate levels of multidrug resistance in Bo, Sierra Leone, a molecular epidemiological study was conducted using an antimicrobial resistance determinant microarray (ARDM), PCR and DNA sequencing. The study found that 21% of isolates from Mercy Hospital (Bo, Sierra Leone) were tet(X)-positive, all of which originated from urinary specimens. Use of molecular epidemiological surveillance tools has provided the first evidence of tet(X)-containing multidrug-resistant Gram-negative hospital isolates in a hospital in Sierra Leone.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Leski TA,Bangura U,Jimmy DH,Ansumana R,Lizewski SE,Stenger DA,Taitt CR,Vora GJdoi
10.1016/j.ijantimicag.2013.04.014subject
Has Abstractpub_date
2013-07-01 00:00:00pages
83-6issue
1eissn
0924-8579issn
1872-7913pii
S0924-8579(13)00140-4journal_volume
42pub_type
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