Abstract：
:Nasal colonisation with Staphylococcus aureus is a risk factor for invasive infection in human immunodeficiency virus (HIV)-positive individuals. This study aimed to characterise colonising S. aureus from regions with a high HIV prevalence. Single nasal swabs were taken from a total of 374 HIV-positive and 370 healthy individuals. Overall, 202 S. aureus carriers were detected. Compared with healthy individuals, HIV-positive subjects were more likely to be S. aureus nasal carriers (33% vs. 21%; P=0.0001). Isolates from HIV-positive individuals were more often resistant to meticillin (16% vs. 8%; P=0.13), chloramphenicol (47% vs. 16%; P<0.0001), sulfamethoxazole/trimethoprim (SXT) (90% vs. 55%; P<0.0001) and ciprofloxacin (18% vs. 0%; P<0.0001). Strains belonging to the spa clonal complexes 3772/ST25 and 064/ST8 were significantly more often isolated from HIV-positive individuals and exhibited greater resistance to ciprofloxacin, SXT and chloramphenicol (spa-CC 3772) or to meticillin (spa-CC 064), respectively. Panton-Valentine leukocidin gene content was high overall and was equally distributed between isolates from HIV-positive and healthy individuals (33% vs. 30%). Genotypic characteristics of colonising isolates were similar to those reported to cause invasive infection in Nigeria. The HIV pandemic contributes to the evolution of antimicrobial resistance in S. aureus. Measures to contain antimicrobial resistance of S. aureus in Nigeria must target risk groups such as HIV-positive individuals.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Olalekan AO,Schaumburg F,Nurjadi D,Dike AE,Ojurongbe O,Kolawole DO,Kun JF,Zanger Pdoi
10.1016/j.ijantimicag.2012.05.016subject
Has Abstractpub_date
2012-09-01 00:00:00pages
268-72issue
3eissn
0924-8579issn
1872-7913pii
S0924-8579(12)00245-2journal_volume
40pub_type
杂志文章abstract：:Fresh clinical isolates collected from November 1, 1992 through November 1, 1993, were tested by agar dilution against 26 different antimicrobial agents including FK037 and l-ofloxacin. Among the 10 040 organisms tested were Staphylococcus aureus (n = 1222), methicillin-resistant Staphylococcus aureus (MRSA, n = 455),...
journal_title：International journal of antimicrobial agents
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journal_title：International journal of antimicrobial agents
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abstract：:Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) is a frequent cause of acute pyelonephritis (APN), requiring carbapenem therapy. However, alternatives to carbapenems are needed due to the emergence of carbapenemase-producing micro-organisms. The purpose of this study was to compare the clinical effi...
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更新日期：2009-01-01 00:00:00
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更新日期：2010-12-01 00:00:00
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更新日期：2001-12-01 00:00:00
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doi：10.1016/0924-8579(94)00042-s
更新日期：1995-04-01 00:00:00
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章
doi：10.1016/0924-8579(92)90037-r
更新日期：1992-09-01 00:00:00
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journal_title：International journal of antimicrobial agents
pub_type： 杂志文章
doi：10.1016/0924-8579(96)00310-x
更新日期：1996-07-01 00:00:00
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更新日期：1993-01-01 00:00:00
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更新日期：2019-11-01 00:00:00
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更新日期：2020-02-01 00:00:00
