当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS期刊下所有文献 > Detection of the icaADBC gene cluster and biofilm formation in Staphylococcus epidermidis isolates from catheter-related urinary tract infections.

Detection of the icaADBC gene cluster and biofilm formation in Staphylococcus epidermidis isolates from catheter-related urinary tract infections.

Abstract：

:Biofilm production in Staphylococcus epidermidis is an important virulence factor that is mediated by the expression of the icaADBC operon. In this study 41 S. epidermidis isolates obtained from catheter-related urinary tract infections were analyzed for the presence of the icaADBC operon and biofilm formation. Eighteen of 41 isolates (44%) were shown to carry ica-specific DNA, but only 11 isolates (27%) produced biofilms spontaneously under normal growth conditions. Upon induction by external stress or antibiotics, biofilm formation could be stimulated in five of seven ica-positive, biofilm-negative isolates, indicating that the icaADBC expression was down-regulated in these strains. Genetic analyses of the ica gene clusters of the remaining two ica-positive, biofilm-negative strains revealed a spontaneous ICAC::IS256 insertion in one strain. Insertion of the element caused a target site duplication of seven base pairs and a biofilm-negative phenotype. After repeated passages the insertion mutant was able to revert to a biofilm-forming phenotype which was due to the precise excision of IS256 from the icaC gene. The data show that icaC::IS256 integrations occur during S. epidermidis polymer-related infections and the results highlight the biological relevance of the IS256-mediated phase variation of biofilm production in S. epidermidis during an infection.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Cho SH,Naber K,Hacker J,Ziebuhr W

doi

10.1016/s0924-8579(02)00101-2

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

570-5

issue

6

eissn

0924-8579

issn

1872-7913

pii

S0924857902001012

journal_volume

19

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS文献大全
  • Is it possible to achieve bacterial eradication in otitis media with effusion by empirical antibiotic high doses and concomitant administration of acetaminophen? A microbiological and pharmacological study in the gerbil model.

    abstract：:The efficacy of amoxycillin-clavulanic acid (10 and 15 mg/kg amoxycillin) and erythromycin (20 and 50 mg/kg) was assessed in a gerbil model of otitis media with effusion induced by beta-lactamase-producing Haemophilus influenzae. Animals were divided into groups receiving acetaminophen concomitantly or not receiving i...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(03)00148-1

    authors： Parra A,Ponte C,Cenjor C,García-Olmos M,Giménez MJ,Aguilar L,Soriano F

    更新日期：2003-11-01 00:00:00

  • Effects of sub-minimum inhibitory concentrations of antimicrobial agents on Streptococcus mutans biofilm formation.

    abstract：:Many studies have demonstrated that sub-minimum inhibitory concentrations (sub-MICs) of antimicrobial agents can inhibit bacterial biofilm formation. However, the mechanisms by which antimicrobial agents at sub-MICs inhibit biofilm formation remain unclear. At present, most studies are focused on Gram-negative bacteri...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2012.01.009

    authors： Dong L,Tong Z,Linghu D,Lin Y,Tao R,Liu J,Tian Y,Ni L

    更新日期：2012-05-01 00:00:00

  • Dissemination of the chromosomally encoded CMY-2 cephalosporinase gene in Escherichia coli isolated from animals.

    abstract：:In this study, 619 individual Escherichia coli isolates from food-producing and companion animals were analysed to determine the prevalence of the cephalosporinase gene blaCMY-2. In total, 18 CMY-2-producers (2.9%) were detected and exhibited multidrug-resistant phenotypes. One of the CMY-2-producers was found to poss...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2015.04.003

    authors： Fang LX,Sun J,Li L,Deng H,Huang T,Yang QE,Li X,Chen MY,Liao XP,Liu YH

    更新日期：2015-08-01 00:00:00

  • Ceftriaxone activity against Gram-positive and Gram-negative pathogens isolated in US clinical microbiology laboratories from 1996 to 2000: results from The Surveillance Network (TSN) Database-USA.

    abstract：:Ceftriaxone was introduced into clinical practice in the USA in 1985 and was the first extended-spectrum (third-generation) cephalosporin approved for once-daily treatment of patients with Gram-positive or Gram-negative infections. Review of ceftriaxone activity is important given its continued use since the mid-1980s...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(02)00010-9

    authors： Karlowsky JA,Jones ME,Mayfield DC,Thornsberry C,Sahm DF

    更新日期：2002-05-01 00:00:00

  • In vitro and in vivo evaluation of fluoroquinolone resistance associated with DNA gyrase mutations in Francisella tularensis, including in tularaemia patients with treatment failure.

    abstract：:Fluoroquinolones (FQs) are highly effective for treating tularaemia, a zoonosis caused by Francisella tularensis, but failures and relapses remain common in patients with treatment delay or immunocompromised status. FQ-resistant strains of F. tularensis harboring mutations in the quinolone-resistance determining regio...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.03.022

    authors： Sutera V,Hoarau G,Renesto P,Caspar Y,Maurin M

    更新日期：2017-09-01 00:00:00

  • In vitro and intracellular activities of fosfomycin against clinical strains of Listeria monocytogenes.

    abstract：:This study was designed to evaluate the potential role of fosfomycin as a therapeutic agent in human listeriosis. The in vitro activity of fosfomycin against 154 Listeria monocytogenes clinical isolates under conditions that mimic the induction of prfA expression was determined and was correlated with fosfomycin intra...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2013.10.018

    authors： Lepe JA,Torres MJ,Smani Y,Parra-Millán R,Pachón J,Vazquez-Barba I,Aznar J

    更新日期：2014-02-01 00:00:00

  • Characterisation of the metallo-beta-lactamase VIM-6 and its genetic support.

    abstract：:The purpose of this study was to characterise the metallo-beta-lactamase VIM-6 and the genetic environment of the bla(VIM-6) gene. The bla(VIM-6) gene was cloned into an Escherichia coli expression system and the purified VIM-6 enzyme was obtained. VIM-6 has an isoelectric point of 4.9 and a molecular weight of 28.368...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2008.05.017

    authors： Koh TH,Yamaguchi K,Ishii Y

    更新日期：2008-11-01 00:00:00

  • Antimicrobial drug resistance in Taiwan.

    abstract：:Antimicrobial resistance is a major health problem worldwide, but marked variations in the resistance profiles of bacterial pathogens are found between countries and in different patient settings, especially in Asia. In Taiwan, the strikingly high prevalence of resistance to macrolides and streptogramins in clinical i...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/S0924-8579(08)70023-2

    authors： Huang YT,Hsueh PR

    更新日期：2008-11-01 00:00:00

  • Antimicrobial susceptibilities of Pasteurella strains isolated from humans.

    abstract：:The in vitro susceptibilities of 192 consecutive clinical strains of Pasteurella spp. isolated between 1996 and 2003 from soft tissue pus (n = 146), respiratory tract specimens (n = 38) and blood (n = 8) were studied by an agar dilution method. All isolates were susceptible to minocycline, cefotaxime, ofloxacin, cipro...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.02.004

    authors： Lion C,Conroy MC,Carpentier AM,Lozniewski A

    更新日期：2006-04-01 00:00:00

  • A need to revisit clinical breakpoints of tigecycline: effect of atypical non-linear plasma protein binding.

    abstract：:Tigecycline is highly active against various drug-resistant bacteria. The US Food and Drug Administration (FDA) recently issued a black box warning for tigecycline owing to an associated increase in all-cause mortality. Clinical breakpoints of antibiotics are vital in susceptibility testing of pathogens for the select...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.12.008

    authors： Singh RSP,Mukker JK,Drescher SK,Deitchman AN,Derendorf H

    更新日期：2017-04-01 00:00:00

  • Voriconazole minimum inhibitory concentrations are predictive of treatment outcome in experimental murine infections by Candida glabrata.

    abstract：:In this study, 27 clinical isolates of Candida glabrata with voriconazole (VRC) minimum inhibitory concentrations (MICs) ranging from ≤0.03 μg/mL to 8 μg/mL were tested to determine whether in vitro data are predictive of in vivo efficacy. The efficacy of VRC administered at 40 mg/kg was assayed in a neutropenic murin...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2015.12.020

    authors： Sanchis M,Capilla J,Castanheira M,Martin-Vicente A,Sutton DA,Fothergill AW,Wiederhold NP,Guarro J

    更新日期：2016-04-01 00:00:00

  • Time-kill curves as a tool for targeting ceftazidime serum concentration during continuous infusion for treatment of septicaemic melioidosis.

    abstract：:Melioidosis is a fatal community-acquired infection endemic in tropical areas. Ten isolates of the causative microorganism were subjected to time-kill study using a range of ceftazidime concentrations. This study demonstrated that a ceftazidime concentration of eight times the minimum inhibitory concentration yielded ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2005.07.016

    authors： Soontornpas C,Saraya S,Chulasiri M,Chindavijak B,Mootsikapun P

    更新日期：2005-11-01 00:00:00

  • Differences in the evolution of imipenem susceptibility among Klebsiella pneumoniae and Escherichia coli isolates during a 6-year period in a tertiary care hospital.

    abstract：:The evolution of imipenem disk-diffusion susceptibility results of 2652 strains of Klebsiella pneumoniae and 7596 Escherichia coli isolated during the period 2000-2005 were analysed. Screening for production of metallo-beta-lactamases was performed using the EDTA-synergy method. The percentage rate of K. pneumoniae is...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.09.010

    authors： Papaparaskevas J,Pantazatou A,Stefanou I,Mela V,Galatidis N,Avlamis A

    更新日期：2007-02-01 00:00:00

  • Purification and characterisation of a novel antistaphylococcal peptide (ASP-1) from Bacillus sp. URID 12.1.

    abstract：:A strong antistaphylococcal peptide (ASP-1) from Bacillus subtilis URID 12.1 strain that is active against cefoxitin- and methicillin-resistant Staphylococcus aureus clinical isolates was purified to homogeneity by solvent extraction, silica gel-based adsorption chromatography and reversed-phase high-performance liqui...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.08.030

    authors： Chalasani AG,Roy U,Nema S

    更新日期：2018-01-01 00:00:00

  • Antimicrobial resistance of Neisseria gonorrhoeae in Japan, 1993-2002: continuous increasing of ciprofloxacin-resistant isolates.

    abstract：:Susceptibility testing was conducted on 1357 isolates of Neisseria gonorrhoeae isolated from 1993 through 2002 in Japan to assess the antimicrobial resistance. Selected isolates were characterised by auxotype and analysis was done for mutations within the quinolone resistance-determining region (QRDR) in the gyrA and ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.02.005

    authors： Tanaka M,Nakayama H,Notomi T,Irie S,Tsunoda Y,Okadome A,Saika T,Kobayashi I

    更新日期：2004-09-01 00:00:00

  • Emergence of a cefepime- and cefpirome-resistant Citrobacter freundii clinical isolate harbouring a novel chromosomally encoded AmpC beta-lactamase, CMY-37.

    abstract：:Citrobacter freundii strain 4306 was isolated from a urine specimen of a patient in March 2006 in Palestine. This strain showed a unique multidrug resistance phenotype, as it was resistant both to 7-alpha-methoxy- and oxyimino-cephalosporins, including cefepime, cefpirome and monobactams, in addition to quinolones, st...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2008.04.019

    authors： Ahmed AM,Shimamoto T

    更新日期：2008-09-01 00:00:00

  • Contribution of β-lactamase and efflux pump overproduction to tazobactam-piperacillin resistance in clinical isolates of Escherichia coli.

    abstract：INTRODUCTION:Tazobactam-piperacillin (TZP) is a mixture of a broad-spectrum penicillin and an irreversible β-lactamase inhibitor. TZP is effective against Gram-negative bacteria that produce extended-spectrum β-lactamases, and it is used as a first-line or second-line drug to treat serious infections. METHODS:This stu...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.105919

    authors： Suzuki Y,Sato T,Fukushima Y,Nakajima C,Suzuki Y,Takahashi S,Yokota SI

    更新日期：2020-04-01 00:00:00

  • In vitro activity of four fluoroquinolones against Mycobacterium tuberculosis.

    abstract：:The in vitro activity of ciprofloxacin, ofloxacin, levofloxacin and moxifloxacin against strains of Mycobacterium tuberculosis was studied. Moxifloxacin and levofloxacin showed the greatest activity having an MIC(90) of 1 mg/l. The MIC(90) for ofloxacin was 2 mg/l and for ciprofloxacin 4 mg/l. Further studies should b...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(00)00337-x

    authors： Rodríguez JC,Ruiz M,Climent A,Royo G

    更新日期：2001-03-01 00:00:00

  • Multidrug-resistant high-risk Enterococcus faecium clones: can we really define them?

    abstract：:Enterococcus faecium is a significant opportunistic human pathogen with a broad host range, including humans, farm animals, pets and wildlife. Specialised subpopulations have globally evolved towards a powerful and convergent adaption to the healthcare environment by acquiring a cocktail of key antimicrobial resistanc...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2020.106227

    authors： Freitas AR,Pereira AP,Novais C,Peixe L

    更新日期：2021-01-01 00:00:00

  • The safety of azithromycin in the treatment of adults with community-acquired respiratory tract infections.

    abstract：:The comparative safety of azithromycin was assessed in adult patients (> or =12 years) with community-acquired respiratory tract infections. Of 3229 patients evaluated, 1616 received azithromycin 500 mg once daily for 3 days and 1613 received standard regimens of amoxycillin, amoxycillin/clavulanic acid, cefaclor, cla...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(01)00490-3

    authors： Treadway G,Pontani D,Reisman A

    更新日期：2002-03-01 00:00:00

  • Do antibacterial and antifungal combinations have better activity against clinically relevant fusarium species? in vitro synergism.

    abstract：:The aim of this study was to evaluate the susceptibility of 20 clinical isolates of Fusarium spp. to classic antifungals [amphotericin B (AmB), itraconazole (ITR), voriconazole (VRC) and caspofungin (CAS)] and to non-antifungal agents [amiodarone (AMD), doxycycline (DOX) and moxifloxacin (MFX)] by the broth microdilut...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.10.017

    authors： Venturini TP,Al-Hatmi AMS,Rossato L,Azevedo MI,Keller JT,Weiblen C,Santurio JM,Alves SH

    更新日期：2018-05-01 00:00:00

  • Genetic diversity of Streptococcus pneumoniae in Tunisia.

    abstract：OBJECTIVES:This study aimed to explore the genetic diversity of Streptococcus pneumoniae isolates in a Tunisian pneumology hospital. METHODS:A total of 141 S. pneumoniae strains isolated between 2009-2016 in the microbiology laboratory at A. Mami Hospital of Pneumology were investigated. Antimicrobial susceptibility t...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.09.023

    authors： Midouni B,Mehiri E,Ghariani A,Draoui H,Essalah L,Bouzouita I,Raoult D,Slim-Saidi L,Fournier PE

    更新日期：2019-01-01 00:00:00

  • Effect of the antimicrobial decapeptide KSL on the growth of oral pathogens and Streptococcus mutans biofilm.

    abstract：:Dental caries and periodontitis are common oral bacterial infectious diseases. Their prevention and treatment requires control of the causative pathogens, such as Streptococcus mutans and Porphyromonas gingivalis, that exist within dental plaque. As one of the attractive future substitutes for conventional antibiotics...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2010.08.014

    authors： Liu Y,Wang L,Zhou X,Hu S,Zhang S,Wu H

    更新日期：2011-01-01 00:00:00

  • Continuous versus intermittent infusion of cefepime in neurosurgical patients with post-operative intracranial infections.

    abstract：:Cefepime is administered as an intermittent infusion (II); however, continuous infusion (CI) may be advantageous because β-lactam antibiotics exhibit time-dependent antibacterial activity. This retrospective, non-randomised, comparative study included 68 neurosurgical patients with post-operative intracranial infectio...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2013.08.019

    authors： Huang H,Huang S,Zhu P,Xi X

    更新日期：2014-01-01 00:00:00

  • Impact of vancomycin minimum inhibitory concentration on clinical outcomes of patients with vancomycin-susceptible Staphylococcus aureus infections: a meta-analysis and meta-regression.

    abstract：:Although the vancomycin minimum inhibitory concentration (VMIC) susceptibility breakpoint for Staphylococcus aureus was recently lowered to ≤2 mg/L, it is argued that isolates in the higher levels of the susceptible range may bear adverse clinical outcomes. Clinical outcomes (all-cause mortality and treatment failure)...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ijantimicag.2012.07.023

    authors： Mavros MN,Tansarli GS,Vardakas KZ,Rafailidis PI,Karageorgopoulos DE,Falagas ME

    更新日期：2012-12-01 00:00:00

  • Safety and efficacy of lomefloxacin and cefaclor in the treatment of skin and skin structure infections.

    abstract：:The purpose of this study was to compare the safety and efficacy of lomefloxacin with that of cefaclor in the treatment of adult secondary bacterial skin and skin structure infections. The study was conducted as a randomized, single-blind comparison. Eighty patients enrolled in the study, of which 74 were evaluable: 3...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/0924-8579(92)90028-p

    authors： Amaya-Tapia G,Andrade-Villanueva J,Flores-Gaxiola A,Aguirre-Avalos G,Morfin-Otero R,Esparza-Ahumada S,Rodriguez-Noriega E

    更新日期：1992-12-01 00:00:00

  • Efficacy of NND-502, a novel imidazole antimycotic agent, in experimental models of Candida albicans and Aspergillus fumigatus infections.

    abstract：:In vitro and in vivo anti-Candida albicans and anti-Aspergillus fumigatus activities of NND-502, a new imidazole-antimycotic, were compared with those of fluconazole (FCZ), itraconazole (ITZ) and/or amphotericin B (AmB). NND-502 exhibited strong in vitro antifungal activity against both fungal species; its MIC against...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(99)00076-x

    authors： Niwano Y,Kuzuhara N,Goto Y,Munechika Y,Kodama H,Kanai K,Yoshida M,Miyazaki T,Yamaguchi H

    更新日期：1999-08-01 00:00:00

  • Quinolones in the treatment of complicated urinary tract infection.

    abstract：:Complicated and recurrent urinary tract infections present intriguing clinical management problems. The underlying conditions in patients with complicated urinary tract infections are anatomical abnormalities of the genitourinary tract, neurologic disorders resulting in urinary stasis, obstruction, instrumentation, su...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/0924-8579(94)90019-1

    authors： Graninger W,Wenisch C,Presterl E

    更新日期：1994-07-01 00:00:00

  • Oritavancin: a novel lipoglycopeptide active against Gram-positive pathogens including multiresistant strains.

    abstract：:Oritavancin is a lipoglycopeptide antibiotic under investigation for the treatment of serious infections caused by Gram-positive bacteria. Oritavancin has demonstrated rapid dose-dependent bactericidal activity towards vancomycin-susceptible and -resistant enterococci, meticillin-susceptible and -resistant Staphylococ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2010.06.048

    authors： Bouza E,Burillo A

    更新日期：2010-11-01 00:00:00

  • Resistance patterns in Turkey.

    abstract：:Resistance to antimicrobial agents in Gram-positive and Gram-negative bacteria is common in Turkey. In this review, resistance to several antimicrobial agents in this country is discussed for bacteria which have gained clinical importance in recent years. Among Gram-positives, staphylococci are of major importance bec...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/0924-8579(95)00026-5

    authors： Gür D,Unal S,Akalin HE

    更新日期：1995-09-01 00:00:00