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Comparative in vitro activity of l-ofloxacin and FK037 to other agents against 10,040 fresh clinical isolates.

Abstract：

:Fresh clinical isolates collected from November 1, 1992 through November 1, 1993, were tested by agar dilution against 26 different antimicrobial agents including FK037 and l-ofloxacin. Among the 10 040 organisms tested were Staphylococcus aureus (n = 1222), methicillin-resistant Staphylococcus aureus (MRSA, n = 455), Staphylococcus epidermidis (n = 533), Staphylococcus hominis (n = 90), Staphylococcus hemolyticus (n = 89), Streptococcus pneumoniae (n = 144), Escherichia coli (n = 2326), Klebsiella pneumoniae (n = 745), Enterobacter cloacae (n = 258), Proteus mirabilis (n = 445), Pseudomonas aeruginosa (n = 998), and Stenotrophomonas (Xanthomonas) maltophilia (n = 102). Both l-ofloxacin and FK037 inhibited 98% of S. aureus strains at 4 mug/ml. FK037 was at least 4 times more effective than the third generation cephalosporins against MRSA, inhibiting 79% of the strains at 16 mug/ml. While the potency of these agents looks promising, their clinical utility will depend in part upon the maximal dosage that can be safely administered.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Cooper I,Isbell DJ,Kruszynski JA,Peterson LR

doi

10.1016/0924-8579(95)00039-9

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

201-21

issue

4

eissn

0924-8579

issn

1872-7913

pii

0924-8579(95)00039-9

journal_volume

6

pub_type

杂志文章

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