Abstract:
:The penetration of the new quinolene rufloxacin into human professional phagocytic cells and different cell types was determined. The intracellular distribution was demonstrated in all cells studied. At 4 degrees C the transport of rufloxacin was reduced. An intracellular dose-dependent activity was demonstrated for rufloxacin in monocytes and granulocytes infected with E. coli and S. aureus. In all the experiments rufloxacin was able to eliminate all intracellular bacteria.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Bonina L,Arena A,Cesana M,Costa GB,Mastroeni F,Carbone Mdoi
10.1016/0924-8579(93)90049-bsubject
Has Abstractpub_date
1993-02-01 00:00:00pages
111-6issue
2eissn
0924-8579issn
1872-7913pii
0924-8579(93)90049-Bjournal_volume
2pub_type
杂志文章abstract::The objective of this study was to examine the in vitro synergism of three-drug combinations against Mycobacterium tuberculosis (levofloxacin/linezolid/ethambutol, levofloxacin/amikacin/ethambutol and levofloxacin/linezolid/amikacin) using the time-kill curves method. In total, 8 multidrug-resistant and 12 drug-suscep...
journal_title:International journal of antimicrobial agents
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abstract::Clostridium difficile infection (CDI) is the leading cause of infectious healthcare-associated diarrhoea. Recurrent CDI increases disease morbidity and mortality, posing a high burden to patients and a growing economic burden to the healthcare system. Thus, there exists a significant unmet and increasing medical need ...
journal_title:International journal of antimicrobial agents
pub_type: 杂志文章,评审
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更新日期:2010-02-01 00:00:00
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journal_title:International journal of antimicrobial agents
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abstract::In 2008, the Scottish Management of Antimicrobial Resistance Action Plan (ScotMARAP) was published by the Scottish Government. One of the key actions was initiation of the Scottish Antimicrobial Prescribing Group (SAPG), hosted within the Scottish Medicines Consortium, to take forward national implementation of the ke...
journal_title:International journal of antimicrobial agents
pub_type: 杂志文章,评审
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abstract::Interest in home care for patients with serious infections is increasing. Home care technology needs reliable equipment that can be operated by the patient without constant supervision. To achieve long-term home treatment requires the establishment of protocols, education programmes, patient support and easy hospital ...
journal_title:International journal of antimicrobial agents
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journal_title:International journal of antimicrobial agents
pub_type: 杂志文章
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journal_title:International journal of antimicrobial agents
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journal_title:International journal of antimicrobial agents
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abstract::This study evaluated the activity of colistin, rifampicin, imipenem and sulbactam/ampicillin alone or in combination against nine epidemic multidrug-resistant Acinetobacter baumannii isolates producing OXA-58 carbapenemase in Naples, Italy. The isolates were susceptible to colistin but differed in their resistance to ...
journal_title:International journal of antimicrobial agents
pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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journal_title:International journal of antimicrobial agents
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2009-11-01 00:00:00
abstract::The objective of this study was to obtain data on the susceptibility of pathogens responsible for acute uncomplicated cystitis in South Korea to currently used antimicrobial agents. A total of 239 isolates were obtained from female outpatients with acute uncomplicated cystitis. The most prevalent causative organism wa...
journal_title:International journal of antimicrobial agents
pub_type: 杂志文章,多中心研究
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更新日期:2004-09-01 00:00:00
abstract::Wide-spectrum quinolones such as moxifloxacin and levofloxacin as well as high-order cephalosporins such as cefoperazone and cefepime have increased antimicrobial activity. However, little is known about their distribution in fetal blood. Therefore, the aim of this study was to measure and compare maternal and fetal b...
journal_title:International journal of antimicrobial agents
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journal_title:International journal of antimicrobial agents
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doi:10.1016/j.ijantimicag.2010.12.018
更新日期:2011-04-01 00:00:00
abstract::Oritavancin is a lipoglycopeptide antibiotic under investigation for the treatment of serious infections caused by Gram-positive bacteria. Oritavancin has demonstrated rapid dose-dependent bactericidal activity towards vancomycin-susceptible and -resistant enterococci, meticillin-susceptible and -resistant Staphylococ...
journal_title:International journal of antimicrobial agents
pub_type: 杂志文章,评审
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更新日期:2010-11-01 00:00:00
abstract::In this study, we investigated the in vivo efficacy of anidulafungin during the early phase of disseminated candidiasis in a neutropenic murine model and compared the results with those obtained for fluconazole. Antifungal efficacy was evaluated by reduction of fungal burden in the tissues of infected animals at perio...
journal_title:International journal of antimicrobial agents
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更新日期:1998-08-01 00:00:00
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journal_title:International journal of antimicrobial agents
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更新日期:2008-08-01 00:00:00
abstract::In the process of endourological development a variety of foreign bodies have been invented besides urinary catheters, on which biofilm can be formed. Bacteria in the biofilm are less susceptible to antibiotics. An additional problem of medical biomaterials in the urinary tract environment is the development of encrus...
journal_title:International journal of antimicrobial agents
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doi:10.1016/j.ijantimicag.2003.12.007
更新日期:2004-03-01 00:00:00
abstract::The efficacy of amoxycillin-clavulanic acid (10 and 15 mg/kg amoxycillin) and erythromycin (20 and 50 mg/kg) was assessed in a gerbil model of otitis media with effusion induced by beta-lactamase-producing Haemophilus influenzae. Animals were divided into groups receiving acetaminophen concomitantly or not receiving i...
journal_title:International journal of antimicrobial agents
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journal_title:International journal of antimicrobial agents
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更新日期:2008-09-01 00:00:00
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journal_title:International journal of antimicrobial agents
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journal_title:International journal of antimicrobial agents
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journal_title:International journal of antimicrobial agents
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abstract::Piperacillin-tazobactam (PIP-TAZ) is commonly used to treat intraabdominal infections; however, its penetration into abdominal sites is unclear. A pharmacokinetic analysis of plasma, peritoneal fluid, and peritoneum drug concentrations was conducted to simulate dosing regimens needed to attain the pharmacodynamic targ...
journal_title:International journal of antimicrobial agents
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更新日期:2017-09-01 00:00:00
abstract::In this first multi-centre study in Scotland, 1028 consecutive Gram-negative and staphylococci strains were obtained from four major teaching hospitals. E. coli was the most common organism among both intensive care units (ICUs) (39%) and non-ICU strains (46.6%). The prevalence of antibiotic resistance among E. coli w...
journal_title:International journal of antimicrobial agents
pub_type: 杂志文章
doi:10.1016/0924-8579(96)00310-x
更新日期:1996-07-01 00:00:00
abstract::Recurrence of Clostridium difficile infection (CDI) has major consequences for both patients and the health system. The ability to predict which patients are at increased risk of recurrent CDI makes it possible to select candidates for treatment with new drugs and therapies (including fecal microbiota transplantation)...
journal_title:International journal of antimicrobial agents
pub_type: 杂志文章
doi:10.1016/j.ijantimicag.2017.09.010
更新日期:2018-03-01 00:00:00