当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS期刊下所有文献 > In vitro time-kill curves study of three antituberculous combinations against Mycobacterium tuberculosis clinical isolates.

In vitro time-kill curves study of three antituberculous combinations against Mycobacterium tuberculosis clinical isolates.

Abstract：

:The objective of this study was to examine the in vitro synergism of three-drug combinations against Mycobacterium tuberculosis (levofloxacin/linezolid/ethambutol, levofloxacin/amikacin/ethambutol and levofloxacin/linezolid/amikacin) using the time-kill curves method. In total, 8 multidrug-resistant and 12 drug-susceptible M. tuberculosis isolates were used. Minimum inhibitory concentrations (MICs) of the isolates for each drug were determined by the proportions method. Time-kill curves were studied for the three combinations proposed over 14 days using two different protocols. In protocol 1, 0.5× MIC for each drug was used. In protocol 2, 0.5× MIC for levofloxacin and linezolid and 0.25× MIC for amikacin and ethambutol were used. The MICs for all of the isolates studied were 0.5 mg/L for levofloxacin and linezolid and 2.5 mg/L for ethambutol and amikacin. All of the combinations displayed an additive activity compared with the most active individual drug. In conclusion, these results demonstrate that the three combinations tested were equally effective against M. tuberculosis isolates. The study of antituberculous combinations using in vitro methods is an excellent first step to predict their effect in clinical development phases as well as to test new regimens of the antituberculous drugs currently available.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

López-Gavín A,Tudó G,Rey-Jurado E,Vergara A,Hurtado JC,Gonzalez-Martín J

doi

10.1016/j.ijantimicag.2015.10.016

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

97-100

issue

1

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(15)00367-2

journal_volume

47

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS文献大全
  • The changing epidemiology of invasive fungal infections: new threats.

    abstract：:The epidemiology of invasive fungal infections is currently at a crucial stage. Potentially fatal fungal strains are emerging that are resistant to many commonly used antifungal agents. It is therefore important to recognize and minimize the major risk factors associated with infection. This paper summarizes the key e...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2006.03.006

    authors： Maschmeyer G

    更新日期：2006-06-01 00:00:00

  • Antimicrobial and cancer cell growth inhibitory activities of 3beta-acetoxy-17beta-(L-prolyl)amino-5alpha-androstane in vitro.

    abstract：:The in vitro activity of the steroidal amide 3beta-acetoxy-17beta-(L-prolyl)amino-5alpha-androstane against 179 gram-positive clinical isolates was examined. The minimum bactericidal concentration (MBC)/MIC ratios were < or = 2 for 73% of methicillin-resistant Staphyllococcus aureus, 59% of vancomycin-resistant Entero...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(00)00156-4

    authors： Pettit RK,Cage GD,Pettit GR,Liebman JA

    更新日期：2000-08-01 00:00:00

  • Fusidic acid in bone and joint infections.

    abstract：:The prominence of staphylococci as the causative agent in bone and joint infections suggests that fusidic acid (FA) has a potentially important role in their treatment. FA has been studied in a broad range of orthopaedic infections, mostly in combination with other antimicrobials. For susceptible organisms, particular...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/s0924-8579(98)00077-6

    authors： Atkins B,Gottlieb T

    更新日期：1999-08-01 00:00:00

  • High prevalence of carbapenem resistance among plasmid-mediated AmpC β-lactamase-producing Klebsiella pneumoniae during outbreaks in liver transplantation units.

    abstract：:During a prospective surveillance using PCR for the detection of plasmid-mediated AmpC β-lactamase (pAmpC)-producing Enterobacteriaceae, outbreaks due to pAmpC-producing Klebsiella pneumoniae (pAmpC-Kp) occurred in an adult liver transplantation unit (aLTU) and a paediatric liver transplantation unit (pLTU), with carb...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2014.08.015

    authors： Matsumura Y,Tanaka M,Yamamoto M,Nagao M,Machida K,Ito Y,Takakura S,Ogawa K,Yoshizawa A,Fujimoto Y,Okamoto S,Uemoto S,Ichiyama S

    更新日期：2015-01-01 00:00:00

  • Legal framework of antimicrobial stewardship in hospitals (LEASH): a European Society of Clinical Microbiology and Infectious Diseases (ESCMID) cross-sectional international survey.

    abstract：:Antimicrobial stewardship (AMS) is the cornerstone activity in the combat against antimicrobial resistance. In order to ensure sustainable deployment and development of AMS, a strategic and regulatory framework needs to be provided by national healthcare authorities. Experts from 32 European countries, Israel and Turk...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.07.019

    authors： Beović B,Pulcini C,Dumartin C,Béraud G,Nerat B,Maurel C,Doušak M,Čižman M,LEASH Study Group on behalf of ESCMID Study Group for Antimicrobial StewardshiP (ESGAP).

    更新日期：2018-11-01 00:00:00

  • Synergistic interactions of sulfamethoxazole and azole antifungal drugs against emerging multidrug-resistant Candida auris.

    abstract：:Candida auris is an emerging multidrug-resistant pathogen implicated in numerous outbreaks worldwide, with a notably high mortality rate (ca. 60%). A significant challenge with treatment of these infections is the resistance of C. auris to most antifungal drugs used clinically. Thus, finding co-drugs capable of overco...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.08.016

    authors： Eldesouky HE,Li X,Abutaleb NS,Mohammad H,Seleem MN

    更新日期：2018-12-01 00:00:00

  • Comparative analysis of azithromycin and ciprofloxacin in the treatment of chronic prostatitis caused by Chlamydia trachomatis.

    abstract：:A total of 89 patients, (>18 years), with symptoms of chronic prostatitis and inflammatory findings as well as the presence of Chlamydia trachomatis confirmed by DNA/RNA DIGENE hybridization method and/or by isolation, McCoy culture and Lugol stain in expressed prostatic secretion or in voided bladder urine collected ...

    journal_title：International journal of antimicrobial agents

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0924-8579(03)00056-6

    authors： Skerk V,Schönwald S,Krhen I,Banaszak A,Begovac J,Strugar J,Strapac Z,Vrsalovic R,Vukovic J,Tomas M

    更新日期：2003-05-01 00:00:00

  • Cellulitis syndromes: an update.

    abstract：:Cellulitis is a commonly seen clinical syndrome that is most often associated with beta-haemolytic streptococci and Staphylococcus aureus. Several medical conditions and a variety of procedures can predispose to the development of cellulitis by a common mechanism: venous and lymphatic compromise. The precise pathophys...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(99)00169-7

    authors： Baddour LM

    更新日期：2000-03-01 00:00:00

  • Polymyxin resistance in carbapenem-resistant Enterobacteriaceae isolates from patients without polymyxin exposure: a multicentre study in China.

    abstract：:Polymyxins were recently approved for the clinical treatment of carbapenem-resistant Enterobacteriaceae (CRE) infections in China. The aim of this study was to determine the prevalence and molecular mechanisms of polymyxin-resistant CRE prior to the clinical application of polymyxin and to evaluate the potential for e...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.106262

    authors： Zhang X,Qu F,Jia W,Huang B,Shan B,Yu H,Tang Y,Chen L,Du H

    更新日期：2020-12-23 00:00:00

  • Vancomycin resistance in Enterococcus faecium isolated from Danish chicken meat is located on a pVEF4-like plasmid persisting in poultry for 18 years.

    abstract：:The occurrence of vancomycin-resistant Enterococcus faecium (VREfm) in food is relevant to public health as foodborne VREfm may colonize the gut of consumers and transfer vancomycin resistance genes to the indigenous gut microbiota. Therefore, we determined occurrence and elucidated genetic traits of VREfm in Danish r...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.03.019

    authors： Leinweber H,Alotaibi SMI,Overballe-Petersen S,Hansen F,Hasman H,Bortolaia V,Hammerum AM,Ingmer H

    更新日期：2018-08-01 00:00:00

  • Antibiotic prophylaxis in head and neck oncologic surgery: the role of gram-negative coverage.

    abstract：:Many studies have elucidated the risk factors associated with peri-operative infection following head and neck cancer surgery (HNS), the implications of infection for total treatment cost, and the clinical benefits of successful antimicrobial prophylaxis. The most appropriate antibiotic use is achieved by focusing on ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/s0924-8579(99)00088-6

    authors： Callender DL

    更新日期：1999-08-01 00:00:00

  • In vitro susceptibility of cultured human methanogens to lovastatin.

    abstract：:Lovastatin is a prodrug that is hydrolysed in vivo to β-hydroxy acid lovastatin, which inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-Co-A) reductase (HMGR), thereby lowering cholesterol in humans. A side effect of lovastatin is inhibition of isoprenoid synthesis and cell membrane formation in methanogenic Archae...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.09.026

    authors： Demonfort Nkamga V,Armstrong N,Drancourt M

    更新日期：2017-02-01 00:00:00

  • Clinical outcomes and therapeutic options of bloodstream infections caused by extended-spectrum beta-lactamase-producing Escherichia coli.

    abstract：:This study was conducted to assess the clinical outcomes of bloodstream infections caused by extended-spectrum beta-lactamase-producing Escherichia coli. A total of 53 patients were included in the study. Forty-five patients (84.9%) received appropriate antibiotic therapy. Initial empirical treatment was appropriate i...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2005.06.012

    authors： Metan G,Zarakolu P,Cakir B,Hascelik G,Uzun O

    更新日期：2005-09-01 00:00:00

  • Outcomes of adjunctive therapy with intrathecal or intraventricular administration of colistin for post-neurosurgical meningitis and ventriculitis due to carbapenem-resistant acinetobacter baumannii.

    abstract：:The efficacy and safety of intrathecal (ITH) or intraventricular (IVT) colistin in addition to intravenous (IV) colistin for meningitis and ventriculitis due to carbapenem-resistant Acinetobacter baumannii (CRAB) is unclear. In this retrospective observational study of 40 patients with post-neurosurgical meningitis an...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.12.002

    authors： Chusri S,Sakarunchai I,Kositpantawong N,Panthuwong S,Santimaleeworagun W,Pattharachayakul S,Singkhamanan K,Doi Y

    更新日期：2018-04-01 00:00:00

  • Disposition and intracellular activity of azithromycin in human THP-1 acute monocytes.

    abstract：:Uptake of [14C]-azithromycin into THP-1 human monocytes was determined at pH 7.4, 6.8 or 5.5 over 4-log antibiotic concentrations for 24 h under a number of conditions. Stimulation of cells was with bacteria, latex beads, lipopolysaccharide (LPS), or zymogen A. Subcellular organelle disposition was determined after is...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(02)00187-5

    authors： Hall IH,Schwab UE,Ward ES,Butts JD,Wolford ET,Ives TJ

    更新日期：2002-11-01 00:00:00

  • Development of amikacin resistance in bacterial isolates in Slovakia (1990-1992).

    abstract：:In-vitro susceptibility of 7301 clinical isolates of Gram-negative bacilli, originating from hospitals at and around Bratislava, to amikacin was evaluated during the years 1990-1992. In 1990 amikacin resistance represented 4.1%, in 1991 it increased to 7.3% and in 1992 a slight decline to 6.4% was observed. In Slovaki...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/0924-8579(94)90064-7

    authors： Milosovic P,Macicková T,Kettner M,Kallová J

    更新日期：1994-03-01 00:00:00

  • Adverse events of fluoroquinolones vs. other antimicrobials prescribed in primary care: A systematic review and meta-analysis of randomized controlled trials.

    abstract：BACKGROUND:Fluoroquinolones (FQs) are second-line antimicrobial agents. Once the decision to prescribe an antimicrobial is made, the choice of antimicrobial should be based on both the benefits and adverse effects. This systematic review quantifies the occurrence of common adverse events (AEs) related to FQs in relatio...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.ijantimicag.2018.04.014

    authors： Tandan M,Cormican M,Vellinga A

    更新日期：2018-11-01 00:00:00

  • Clinical relevance of a European collaborative study on comparative susceptibility of gram-positive clinical isolates to teicoplanin and vancomycin.

    abstract：:Seventy laboratories in nine European countries (Belgium, France, Germany, Italy, The Netherlands, Portugal, Spain, Switzerland and the UK) each collected 100 consecutive gram-positive bacterial pathogens during 1995. MICs were determined by a co-ordinating laboratory in each country using an agar incorporation method...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0924-8579(98)00050-8

    authors： Grüneberg RN,Hryniewicz W

    更新日期：1998-11-01 00:00:00

  • Antimicrobial susceptibility of uropathogens causing acute uncomplicated cystitis in female outpatients in South Korea: a multicentre study in 2002.

    abstract：:The objective of this study was to obtain data on the susceptibility of pathogens responsible for acute uncomplicated cystitis in South Korea to currently used antimicrobial agents. A total of 239 isolates were obtained from female outpatients with acute uncomplicated cystitis. The most prevalent causative organism wa...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ijantimicag.2004.02.012

    authors： Lee SJ,Lee SD,Cho IR,Sim BS,Lee JG,Kim CS,Kim ME,Cho YH,Woo YN

    更新日期：2004-09-01 00:00:00

  • The dosing and monitoring of vancomycin: what is the best way forward?

    abstract：:We have evaluated the literature to review optimal dosing and monitoring of intravenous vancomycin in adults, in response to evolving understanding of targets associated with efficacy and toxicity. The area under the total concentration-time curve (0-24 h) divided by the minimum inhibitory concentration (AUC24/MIC) is...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2018.12.014

    authors： Drennan PG,Begg EJ,Gardiner SJ,Kirkpatrick CMJ,Chambers ST

    更新日期：2019-04-01 00:00:00

  • Prevalence of meticillin-resistant and -susceptible coagulase-negative staphylococci with the first detection of the mecC gene among cows, humans and manure in Tunisia.

    abstract：:In Europe, a novel mecA homologue - mecC (formerly mecALGA251) - has emerged recently in staphylococci from animals, humans and the environment. This paper reports the first occurrence of the mecC gene in Staphylococcus sciuri from cows and manure in Tunisia and Africa. Forty-nine coagulase-negative staphylococci (CNS...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.10.007

    authors： Dhaouadi S,Soufi L,Campanile F,Dhaouadi F,Sociale M,Lazzaro L,Cherif A,Stefani S,Elandoulsi RB

    更新日期：2020-01-01 00:00:00

  • Increased rifampicin resistance in blood isolates of meticillin-resistant Staphylococcus aureus (MRSA) amongst patients exposed to rifampicin-containing antituberculous treatment.

    abstract：:The aim of this study was to determine the rifampicin (RIF) resistance rate of meticillin-resistant Staphylococcus aureus (MRSA) amongst patients with MRSA bacteraemia who have or have not been exposed to RIF-containing antituberculous (anti-TB) treatment. From 2000 to 2008, patients with MRSA bacteraemia and previous...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2011.01.018

    authors： Tan CK,Lai CC,Liao CH,Lin SH,Huang YT,Hsueh PR

    更新日期：2011-06-01 00:00:00

  • Uncommon Detection of Mixed HCV Genotype Infections in Recently Infected Men Who Have Sex with Men.

    abstract：INTRODUCTION:Mixed hepatitis C virus (HCV) genotype (GT) infections are clinically important as different genotypes have varied sensitivities to direct-acting antivirals (DAAs). A high prevalence of mixed GT infections was observed in individuals who inject drugs and had multiple HCV exposures. The prevalence of mixed ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.06.001

    authors： Nguyen T,Delaugerre C,Valantin MA,Amiel C,Netzer E,L'Yavanc T,Ohayon M,Israel G,Valin N,Day N,Kreplak G,Pialoux G,Calvez V,Molina JM,Marcelin AG,Todesco E

    更新日期：2019-10-01 00:00:00

  • Emergence of a cefepime- and cefpirome-resistant Citrobacter freundii clinical isolate harbouring a novel chromosomally encoded AmpC beta-lactamase, CMY-37.

    abstract：:Citrobacter freundii strain 4306 was isolated from a urine specimen of a patient in March 2006 in Palestine. This strain showed a unique multidrug resistance phenotype, as it was resistant both to 7-alpha-methoxy- and oxyimino-cephalosporins, including cefepime, cefpirome and monobactams, in addition to quinolones, st...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2008.04.019

    authors： Ahmed AM,Shimamoto T

    更新日期：2008-09-01 00:00:00

  • Survey of extended-spectrum beta-lactamases in Escherichia coli isolates from a Portuguese hospital and characterisation of a novel class 1 integron (In60A) carrying the blaCTX-M-9 gene.

    abstract：:Between November 2001 and November 2004, 231 Escherichia coli isolates resistant to beta-lactam antibiotics were identified. In 14 isolates, bla(TEM-24) (2 isolates), bla(TEM-52) (5 isolates) and bla(TEM-26) (7 isolates) were identified. In 145 E. coli isolates with the same M13 fingerprinting profile and the same res...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.08.002

    authors： Brizio A,Vasco S,Gonçalves AR,Lito LM,Cristino JM,Salgado MJ,Duarte A

    更新日期：2006-10-01 00:00:00

  • Potency of DX-619, a novel des-F(6)-quinolone, in haematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.

    abstract：:In this study, the potency of DX-619, a novel des-fluoro(6)-quinolone agent, was compared with that of vancomycin (VCM) in a murine model of haematogenous bronchopneumonia infection caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate S. aureus (VISA). The minimum inhibitory concent...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.03.026

    authors： Yanagihara K,Seki M,Izumikawa K,Higashiyama Y,Miyazaki Y,Hirakata Y,Tomono K,Mizuta Y,Tsukamoto K,Kohno S

    更新日期：2006-09-01 00:00:00

  • Caspofungin: an advanced treatment approach for suspected or confirmed invasive aspergillosis.

    abstract：:Invasive aspergillosis occurs in a wide range of immunocompromised patients and is typically associated with an extremely poor prognosis. Caspofungin represents an additional therapeutic alternative to standard antifungal therapies in patients with suspected or confirmed invasive aspergillosis, as evidenced by a growi...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2006.03.019

    authors： Maertens J

    更新日期：2006-06-01 00:00:00

  • Approaching zero: temporal effects of a restrictive antibiotic policy on hospital-acquired Clostridium difficile, extended-spectrum β-lactamase-producing coliforms and meticillin-resistant Staphylococcus aureus.

    abstract：:A restrictive antibiotic policy banning routine use of ceftriaxone and ciprofloxacin was implemented in a 450-bed district general hospital following an educational campaign. Monthly consumption of nine antibiotics was monitored in defined daily doses (DDDs) per 1000 patient-occupied bed-days (1000 pt-bds) 9 months be...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2012.10.013

    authors： Dancer SJ,Kirkpatrick P,Corcoran DS,Christison F,Farmer D,Robertson C

    更新日期：2013-02-01 00:00:00

  • Mechanisms of antibiotic neurotoxicity in renal failure.

    abstract：:Neurological complications of antibiotics are relatively common in renal failure. Central nervous system neurotoxicity due to penicillin and beta-lactam antibiotics is best documented with fewer accounts of ototoxicity, peripheral nerve toxicity and neuromuscular blockade. In the context of risk stratification, the go...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2003.11.004

    authors： Chow KM,Szeto CC,Hui AC,Li PK

    更新日期：2004-03-01 00:00:00

  • Activity of linezolid-containing regimens against multidrug-resistant tuberculosis in mice.

    abstract：:The objective of the present study was to compare the activities of regimens containing linezolid (LZD) with those not containing LZD against Mycobacterium tuberculosis infection in mice. The three regimens excluding LZD selected in this study are often used in practice against multidrug-resistant tuberculosis (MDR-TB...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2013.10.010

    authors： Zhao W,Guo Z,Zheng M,Zhang J,Wang B,Li P,Fu L,Liu S

    更新日期：2014-02-01 00:00:00