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HIV resistance and the developing world.

Abstract：

:Rollout of antiretroviral therapy (ART) in resource-limited countries has been identified as a global public health priority. Human immunodeficiency virus (HIV) treatment in the industrialised world is routinely accompanied by regular virological monitoring. By contrast, the implementation of ART in resource-limited settings requires use of standard first- and second-line therapy. One major consequence is the likely emergence of high-level resistance during first-line therapy since most people will stay on a virologically failing regimen for longer periods, potentially compromising the efficacy of second-line therapy. The evidence regarding resistance to triple-drug ART relates to the time at which virological failure occurs in populations from developed countries, with little data from resource-poor contexts where monitoring strategies, HIV subtypes and drug combinations are likely to differ.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Gupta RK,Pillay D

doi

10.1016/j.ijantimicag.2007.01.003

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

510-7

issue

5

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(07)00056-8

journal_volume

29

pub_type

杂志文章,评审

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