Abstract:
OBJECTIVES:This study reported a hospital outbreak due to an extensively drug-resistant (XDR) OXA-72-producing strain of Acinetobacter baumannii (A. baumannii). METHODS AND RESULTS:The isolates were found to be genotypically indistinguishable by whole-genome multiple locus sequence typing, and to belong to the international clonal complex CC2. One of these isolates sequentially developed a high resistance to colistin and rifampicin under treatment, as a result of mutations in genes pmrB and rpoB, respectively. The blaOXA-72 gene was localised on a 10-kb transferable plasmid, named pAB-STR-1, whose sequence is nearly identical to that of another plasmid previously found in Lithuanian strains, pAB120. CONCLUSION:This report highlighted the need to carefully monitor the emergence of colistin and rifampicin resistance in patients treated for infections with multidrug-resistant A. baumannii.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Potron A,Bour M,Triponney P,Muller J,Koebel C,A Bonnin R,Plésiat Pdoi
10.1016/j.ijantimicag.2019.01.012subject
Has Abstractpub_date
2019-05-01 00:00:00pages
669-673issue
5eissn
0924-8579issn
1872-7913pii
S0924-8579(19)30012-3journal_volume
53pub_type
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journal_title:International journal of antimicrobial agents
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