当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS期刊下所有文献 > Antimicrobial activities of LCB10-0200, a novel siderophore cephalosporin, against the clinical isolates of Pseudomonas aeruginosa and other pathogens.

Antimicrobial activities of LCB10-0200, a novel siderophore cephalosporin, against the clinical isolates of Pseudomonas aeruginosa and other pathogens.

Abstract：

:Infections caused by multidrug-resistant bacteria, including Pseudomonas aeruginosa, are threatening public health worldwide. Therefore, a novel antibacterial agent is needed to treat these infections. Here, we investigated the in vitro and in vivo activities of a novel siderophore-conjugated cephalosporin, LCB10-0200, against the clinical isolates of Gram-negative bacteria, including multidrug-resistant P. aeruginosa. In vitro susceptibility to LCB10-0200 was assessed by performing a two-fold agar dilution method, as described by the Clinical and Laboratory Standards Institute. LCB10-0200 showed the most potent antibacterial activity against P. aeruginosa clinical isolates, including β-lactamase-producing strains. Moreover, LCB10-0200 showed better antibacterial activity against recently isolated clinical isolates than its comparators, except colistin. The in vivo activity of LCB10-0200 was examined using four mouse models of systemic, thigh, respiratory tract, and urinary tract infections. LCB10-0200 was more effective than ceftazidime in treating systemic, thigh, respiratory tract, and urinary tract infections caused by drug-susceptible and drug-resistant P. aeruginosa strains in these mouse models. Thus, the potent in vitro and in vivo activities of LCB10-0200 observed in the present study indicate that it has the potential for treating infections caused by Gram-negative bacteria, including P. aeruginosa.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Oh SH,Park HS,Kim HS,Yun JY,Oh K,Cho YL,Kwak JH

doi

10.1016/j.ijantimicag.2017.06.001

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

700-706

issue

6

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(17)30208-X

journal_volume

50

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS文献大全
  • Dissemination of the chromosomally encoded CMY-2 cephalosporinase gene in Escherichia coli isolated from animals.

    abstract：:In this study, 619 individual Escherichia coli isolates from food-producing and companion animals were analysed to determine the prevalence of the cephalosporinase gene blaCMY-2. In total, 18 CMY-2-producers (2.9%) were detected and exhibited multidrug-resistant phenotypes. One of the CMY-2-producers was found to poss...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2015.04.003

    authors： Fang LX,Sun J,Li L,Deng H,Huang T,Yang QE,Li X,Chen MY,Liao XP,Liu YH

    更新日期：2015-08-01 00:00:00

  • Bacterial strain-independent AUC/MIC and strain-specific dose-response relationships reflecting comparative fluoroquinolone anti-pseudomonal pharmacodynamics in an in vitro dynamic model.

    abstract：:To compare the antimicrobial effects (AMEs) of two quinolones in terms of the AUC/MIC- and dose (D)-response relationships, five differentially susceptible clinical isolates of Pseudomonas aeruginosa were exposed to decreasing concentrations of ciprofloxacin (two 12-h doses with T(1/2) = 4 h) and trovafloxacin (a sing...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(02)00116-4

    authors： Lubenko IY,Vostrov SN,Portnoy YA,Zinner SH,Firsov AA

    更新日期：2002-07-01 00:00:00

  • Recent advances and challenges in the treatment of invasive fungal infections.

    abstract：:The frequency of invasive fungal infections (IFIs) has increased over the last decade with the rise in at-risk populations of patients. The morbidity and mortality of IFIs are high and management of these conditions is a great challenge. With the widespread adoption of antifungal prophylaxis, the epidemiology of invas...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2007.07.019

    authors： Shao PL,Huang LM,Hsueh PR

    更新日期：2007-12-01 00:00:00

  • Antimicrobial drug resistance in Taiwan.

    abstract：:Antimicrobial resistance is a major health problem worldwide, but marked variations in the resistance profiles of bacterial pathogens are found between countries and in different patient settings, especially in Asia. In Taiwan, the strikingly high prevalence of resistance to macrolides and streptogramins in clinical i...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/S0924-8579(08)70023-2

    authors： Huang YT,Hsueh PR

    更新日期：2008-11-01 00:00:00

  • Evaluation of antifungal therapy in a neutropenic murine model of Neoscytalidium dimidiatum infection.

    abstract：:We evaluated the efficacy of amphotericin B (1.5mg/kg/day), voriconazole (60mg/kg/day) and posaconazole (60mg/kg/day) in a murine model of systemic infection caused by Neoscytalidium dimidiatum. All the treatments were able to prolong survival and to reduce the tissue burden in the spleen and kidneys of infected mice....

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2009.09.028

    authors： Ruíz-Cendoya M,Madrid H,Pastor J,Guarro J

    更新日期：2010-02-01 00:00:00

  • NCCLS perspectives in changing susceptibility breakpoints for antimicrobial drugs.

    abstract：:The spread of resistance to many antimicrobial agents in various microbial species has been highlighted by the World Health Organisation and many government agencies around the world. The reasons for this increase and spread are complex and are discussed. A number of surveillance studies has monitored the increase in ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2003.08.005

    authors： Gums JG

    更新日期：2003-10-01 00:00:00

  • Combination therapy with polymyxin B for carbapenemase-producing Klebsiella pneumoniae bloodstream infection.

    abstract：:Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) bloodstream infections (BSIs) are related to high mortality rates, and combination therapy has been associated with lower mortality in patients treated mostly with colistin. There is a paucity of studies addressing polymyxin B (PMB) treatment for KPC...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.10.010

    authors： Medeiros GS,Rigatto MH,Falci DR,Zavascki AP

    更新日期：2019-02-01 00:00:00

  • Safety and efficacy of artemisinin-piperaquine for treatment of COVID-19: an open-label, non-randomised and controlled trial.

    abstract：BACKGROUND:There are no effective therapies for patients with coronavirus disease-2019 (COVID-19). METHODS:Forty-one patients with confirmed COVID-19 were enrolled in the study and divided into two groups: artemisinin-piperaquine (AP) (n = 23) and control (n = 18). The primary outcome were the time taken to reach unde...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.106216

    authors： Li G,Yuan M,Li H,Deng C,Wang Q,Tang Y,Zhang H,Yu W,Xu Q,Zou Y,Yuan Y,Guo J,Jin C,Guan X,Xie F,Song J

    更新日期：2021-01-01 00:00:00

  • Lytic bacteriophages against multidrug-resistant Staphylococcus aureus, Enterococcus faecalis and Escherichia coli isolates from orthopaedic implant-associated infections.

    abstract：:Orthopaedic implant-associated infections are a devastating complication of orthopaedic surgery with a significant impact on patients and healthcare systems. The aims of this work were to describe the patterns of antimicrobial resistance, pathogenicity and virulence of clinical bacterial isolates from orthopaedic impl...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.06.007

    authors： Barros J,Melo LDR,Poeta P,Igrejas G,Ferraz MP,Azeredo J,Monteiro FJ

    更新日期：2019-09-01 00:00:00

  • Tigecycline: clinical evidence and formulary positioning.

    abstract：:Tigecycline, is a novel broad-spectrum glycylcycline antibiotic, which has activity against a broad range of Gram-positive, Gram-negative, atypical, anaerobic and antibiotic-resistant bacteria. This includes activity against MRSA, VRE and penicillin resistant Streptococcus pneumoniae. Whilst exhibiting antibacterial a...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2004.11.006

    authors： Nathwani D

    更新日期：2005-03-01 00:00:00

  • Very prolonged liposomal amphotericin B use leading to a lysosomal storage disease.

    abstract：:Amphotericin B is a powerful polyene antifungal drug used for treating systemic fungal infections and is usually administered for a short period. Side effects after prolonged use are unknown in humans. Here we report the case of a 28-year-old man suffering from chronic granulomatous disease (CGD), treated for invasive...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2014.02.015

    authors： Michot JM,Gubavu C,Fourn E,Maigne G,Teicher E,Angoulvant A,Blanche S,Lortholary O,Coilly A,Duclos-Vallée JC,Sebagh M,Guettier C,Aumont C,Delfraissy JF,Lambotte O

    更新日期：2014-06-01 00:00:00

  • Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea.

    abstract：:Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-beta-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, wher...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2008.10.009

    authors： Lee K,Kim MN,Choi TY,Cho SE,Lee S,Whang DH,Yong D,Chong Y,Woodford N,Livermore DM,KONSAR Group.

    更新日期：2009-06-01 00:00:00

  • Antimicrobial drug resistance mechanisms among Mollicutes.

    abstract：:Representatives of the Mollicutes class are the smallest, wall-less bacteria capable of independent reproduction. They are widespread in nature, most are commensals, and some are pathogens of humans, animals and plants. They are also the main contaminants of cell cultures and vaccine preparations. Despite limited bios...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2020.106253

    authors： Chernova OA,Chernov VM,Mouzykantov AA,Baranova NB,Edelstein IA,Aminov RI

    更新日期：2020-11-29 00:00:00

  • Molecular characterisation of cyp51A and cyp51B genes coding for P450 14alpha-lanosterol demethylases A (CYP51Ap) and B (CYP51Bp) from voriconazole-resistant laboratory isolates of Aspergillus flavus.

    abstract：:Aspergillus flavus is the second most common Aspergillus spp. causing invasive infections in immunocompromised patients. Extensive prophylactic use of voriconazole (VCZ) in immunocompromised patients may enhance the selection of VCZ-resistant clinical isolates of A. flavus, compromising the effectiveness of this antif...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2008.06.018

    authors： Krishnan-Natesan S,Chandrasekar PH,Alangaden GJ,Manavathu EK

    更新日期：2008-12-01 00:00:00

  • Eradication of meticillin-resistant Staphylococcus aureus from human skin by the novel LL-37-derived peptide P10 in four pharmaceutical ointments.

    abstract：:Skin bacterial colonization/infection is a frequent cause of morbidity in patients with chronic wounds and allergic/inflammatory skin diseases. This study aimed to develop a novel approach to eradicate meticillin-resistant Staphylococcus aureus (MRSA) from human skin. To achieve this, the stability and antibacterial a...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.07.014

    authors： Nibbering PH,Göblyös A,Adriaans AE,Cordfunke RA,Ravensbergen B,Rietveld MH,Zwart S,Commandeur S,van Leeuwen R,Haisma EM,Schimmel KJM,den Hartigh J,Drijfhout JW,Ghalbzouri AE

    更新日期：2019-11-01 00:00:00

  • Colistin use and colistin resistance in bacteria from animals.

    abstract：:Colistin has been used in veterinary medicine for decades, mainly for the prevention and treatment of Enterobacteriaceae infections. However, data regarding colistin resistance in bacteria from animals and food of animal origin are relatively scarce, partly because there are methodological difficulties hampering the a...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2016.09.016

    authors： Kempf I,Jouy E,Chauvin C

    更新日期：2016-12-01 00:00:00

  • Antimicrobial activity of novel 4H-4-oxoquinolizine compounds against extensively drug-resistant Acinetobacter baumannii strains.

    abstract：:The aim of this study was to screen lead compounds exhibiting potent in vitro antimicrobial activity against multidrug-resistant (MDR) Acinetobacter baumannii strains from a library of chemical compounds. In a high-throughput screening analysis of 7520 compounds representative of 340,000 small molecules, two 4H-4-oxoq...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.10.008

    authors： Na SH,Jeon H,Kim YJ,Kwon HI,Selasi GN,Nicholas A,Yun CS,Lee SH,Lee JC

    更新日期：2017-01-01 00:00:00

  • Antimicrobial susceptibilities of Campylobacter isolated from food-producing animals on farms (1999-2001): results from the Japanese Veterinary Antimicrobial Resistance Monitoring Program.

    abstract：:Nationwide monitoring of antimicrobial resistance in Campylobacter isolated from food-producing animals on farms was performed in Japan. A total of 468 Campylobacter isolates were obtained during the period from June 1999 to March 2001. Campylobacter species showed high frequencies of resistance to oxytetracycline and...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.03.017

    authors： Ishihara K,Kira T,Ogikubo K,Morioka A,Kojima A,Kijima-Tanaka M,Takahashi T,Tamura Y

    更新日期：2004-09-01 00:00:00

  • Quinolones in the treatment of complicated urinary tract infection.

    abstract：:Complicated and recurrent urinary tract infections present intriguing clinical management problems. The underlying conditions in patients with complicated urinary tract infections are anatomical abnormalities of the genitourinary tract, neurologic disorders resulting in urinary stasis, obstruction, instrumentation, su...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/0924-8579(94)90019-1

    authors： Graninger W,Wenisch C,Presterl E

    更新日期：1994-07-01 00:00:00

  • Skin and soft tissue infection: microbiology and epidemiology.

    abstract：:Skin and soft tissue infections (SSTIs) are common and range in severity from minor, self-limiting, superficial infections to life-threatening diseases requiring all the resources of modern medicine. The classification of SSTIs can be based on the anatomical site, clinical severity or microbial cause, but some classif...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/S0924-8579(09)70541-2

    authors： Dryden MS

    更新日期：2009-07-01 00:00:00

  • Treatment of murine Fusarium verticillioides infection with liposomal amphotericin B plus terbinafine.

    abstract：:Using a murine model of disseminated infection by Fusarium verticillioides, the efficacy of liposomal amphotericin (L-AmB) B at 10mg/kg body weight once daily and terbinafine (TRB) at 150 mg/kg body weight twice daily, alone and in combination, was evaluated. The combination of L-AmB with TRB was the only treatment ab...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2010.08.008

    authors： Ruíz-Cendoya M,Pastor FJ,Capilla J,Guarro J

    更新日期：2011-01-01 00:00:00

  • Wide distribution of CC92 carbapenem-resistant and OXA-23-producing Acinetobacter baumannii in multiple provinces of China.

    abstract：:Carbapenem-resistant Acinetobacter baumannii has spread rapidly across China and is currently reported to be a worldwide nosocomial menace. In light of its increasing clinical significance, this study aimed to investigate the molecular epidemiology of carbapenem-resistant and carbapenem-susceptible isolates obtained f...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2013.06.019

    authors： Ruan Z,Chen Y,Jiang Y,Zhou H,Zhou Z,Fu Y,Wang H,Wang Y,Yu Y

    更新日期：2013-10-01 00:00:00

  • P-glycoprotein in helminths: function and perspectives for anthelmintic treatment and reversal of resistance.

    abstract：:Infestation with parasitic helminths is a common problem in human populations of third world countries and is ubiquitous in livestock and other domestic animals. The cell-membrane efflux pump, P-glycoprotein (Pgp), appears to contribute to anthelmintic resistance. Pgp have been identified from both phyla of parasitic ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/s0924-8579(03)00221-8

    authors： Kerboeuf D,Blackhall W,Kaminsky R,von Samson-Himmelstjerna G

    更新日期：2003-09-01 00:00:00

  • Identification and mapping of new chromosomal sites affecting response to beta-lactams in Staphylococcus aureus.

    abstract：:Seven new sites leading to increased beta-lactam susceptibility were identified and mapped in Staphylococcus aureus by Tn551 or Tn917 mediated insertional inactivation. Their effect was more pronounced in methicillin resistant than in susceptible strains. Except for inserts each in SmaI-K and SmaI-B, all were located ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(96)00346-9

    authors： Vasilieva E,Labischinski H,Berger-Bächi B

    更新日期：1997-02-01 00:00:00

  • Evaluation of a risk-guided strategy for empirical carbapenem use in febrile neutropenia.

    abstract：:Febrile neutropenia (FN) is associated with substantial morbidity and necessitates empirical broad-spectrum antimicrobial treatment. In this prospective cohort study, a risk-guided management strategy for FN using empirical piperacillin/tazobactam (TZP) or a carbapenem was evaluated. The analysis involved 723 FN episo...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.04.017

    authors： Khoo AL,Zhao YJ,Teng M,Ying D,Jin J,Chee YL,Poon LM,Lim SE,Koh LP,Chng WJ,Lim BP,Hsu LY,Chai LYA

    更新日期：2018-09-01 00:00:00

  • Discontinuation of antibiotic therapy within 24 hours of treatment initiation for patients with no clinical evidence of bacterial infection: a 5-year safety and outcome study from Singapore General Hospital Antimicrobial Stewardship Program.

    abstract：BACKGROUND:Overprescribing antibiotics for patients with no bacterial infection is of growing global concern. It is important for timely Antimicrobial Stewardship Program (ASP) intervention to discontinue antibiotics for patients whose symptoms can be explained by non-infective causes, and without availability of bacte...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.01.008

    authors： Loo LW,Liew YX,Lee W,Lee LW,Chlebicki P,Kwa AL

    更新日期：2019-05-01 00:00:00

  • Potency of DX-619, a novel des-F(6)-quinolone, in haematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.

    abstract：:In this study, the potency of DX-619, a novel des-fluoro(6)-quinolone agent, was compared with that of vancomycin (VCM) in a murine model of haematogenous bronchopneumonia infection caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate S. aureus (VISA). The minimum inhibitory concent...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.03.026

    authors： Yanagihara K,Seki M,Izumikawa K,Higashiyama Y,Miyazaki Y,Hirakata Y,Tomono K,Mizuta Y,Tsukamoto K,Kohno S

    更新日期：2006-09-01 00:00:00

  • In vitro susceptibility of cultured human methanogens to lovastatin.

    abstract：:Lovastatin is a prodrug that is hydrolysed in vivo to β-hydroxy acid lovastatin, which inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-Co-A) reductase (HMGR), thereby lowering cholesterol in humans. A side effect of lovastatin is inhibition of isoprenoid synthesis and cell membrane formation in methanogenic Archae...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.09.026

    authors： Demonfort Nkamga V,Armstrong N,Drancourt M

    更新日期：2017-02-01 00:00:00

  • Emergence of extended-spectrum β-lactam resistance among Escherichia coli at a US academic children's hospital is clonal at the sequence type level for CTX-M-15, but not for CMY-2.

    abstract：:Resistance to extended-spectrum β-lactams is increasing worldwide among Escherichia coli and has been linked to a small number of emergent clones (e.g. ST38, ST131 and ST405) recovered from extraintestinal infections in community and hospital settings. There are, however, limited data about the relative contributions ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2013.01.006

    authors： Weissman SJ,Adler A,Qin X,Zerr DM

    更新日期：2013-05-01 00:00:00

  • Characterisation and risk factor profiling of Pseudomonas aeruginosa urinary tract infections: pinpointing those likely to be caused by multidrug-resistant strains.

    abstract：:This study aimed to characterise UTIs caused by Pseudomonas aeruginosa in hospitalised adults and to identify risk factors for infections caused by multidrug-resistant (MDR) strains. A retrospective case-case-control study was conducted in two Italian teaching hospitals. Totally, 242 monomicrobial P. aeruginosa UTIs w...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.105900

    authors： Tumbarello M,Raffaelli F,Peghin M,Losito AR,Chirico L,Giuliano G,Spanu T,Sartor A,Fiori B,Bassetti M

    更新日期：2020-04-01 00:00:00