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Very prolonged liposomal amphotericin B use leading to a lysosomal storage disease.

Abstract：

:Amphotericin B is a powerful polyene antifungal drug used for treating systemic fungal infections and is usually administered for a short period. Side effects after prolonged use are unknown in humans. Here we report the case of a 28-year-old man suffering from chronic granulomatous disease (CGD), treated for invasive cerebral aspergillosis with liposomal amphotericin B (L-AmB) for a very long time (8 consecutive years). We describe the efficacy and safety of this treatment in the long term. Aspergillosis was kept under control as long as L-AmB therapy was maintained, but relapsed when the dose was reduced. No overt renal toxicity was noted. The patient gradually developed hepatosplenomegaly and pancytopenia. Abnormalities of bone marrow were similar to the sea-blue histiocyte syndrome. Liver biopsy showed images of nodular regenerative hyperplasia related to CGD as well as a histiocytic storage disease. We discuss the very prolonged use of L-AmB leading to the development of a lysosomal storage disease.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Michot JM,Gubavu C,Fourn E,Maigne G,Teicher E,Angoulvant A,Blanche S,Lortholary O,Coilly A,Duclos-Vallée JC,Sebagh M,Guettier C,Aumont C,Delfraissy JF,Lambotte O

doi

10.1016/j.ijantimicag.2014.02.015

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

566-9

issue

6

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(14)00087-9

journal_volume

43

pub_type

杂志文章

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