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A pilot study evaluating the safety and effectiveness of Lactobacillus vaginal suppositories in patients with recurrent urinary tract infection.

Abstract：

:Changes in the indigenous vaginal microflora with uropathogenic bacteria can predispose women to frequently recurring bacterial cystitis. Lactobacilli used as probiotics have played an important role in preventing the colonization of pathogenic bacteria in the vagina. A prospective clinical pilot study was performed to confirm the safety and effectiveness of Lactobacillus vaginal suppositories against the recurrence of bacterial urinary tract infection (UTI). The patients enrolled in the study were instructed to administer vaginal suppositories containing the strain Lactobacillus crispatus GAI 98322. A significant reduction in the number of recurrences was noted, without any adverse complication (P=0.0007). The administration of vaginal suppositories containing L. crispatus GAI 98332 seemed to be a safe and promising treatment for the prevention of recurrent UTI.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Uehara S,Monden K,Nomoto K,Seno Y,Kariyama R,Kumon H

doi

10.1016/j.ijantimicag.2006.05.008

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

S30-4

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(06)00175-0

journal_volume

28 Suppl 1

pub_type

临床试验,杂志文章

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