Abstract:
:The chequerboard technique was used to look for synergistic combinations of ceftazidime, imipenem and pefloxacin. The synergistic combinations were used in vivo in mice experimentally infected with Escherichia coli, Salmonella typhimurium and Pseudomonas aeruginosa. In vitro ceftazidime/imipenem, ceftazidime/pefloxacin and pefloxacin/imipenem combinations showed synergistic effects against Staphylococcus aureus and S. typhimurium and additive effects against P. aeruginosa. Only the ceftazidime/pefloxacin combination was synergistic against E. coli while the ceftazidime/imipenem and pefloxacin/imipenem combinations resulted in additive effects. In vivo, combination of ceftazidime/imipenem against E. coli infection and the pefloxacin/imipenem combination against S. typhimurium infection were protective.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
El-Sukhon SN,Faiza Boukhatem Zdoi
10.1016/s0924-8579(03)00127-4subject
Has Abstractpub_date
2003-12-01 00:00:00pages
613-7issue
6eissn
0924-8579issn
1872-7913pii
S0924857903001274journal_volume
22pub_type
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