Synthesis, antimicrobial activity and toxicity to nematodes of cyclam derivatives.

abstract：:In this study, 183 Salmonella enterica isolates were characterised for integrons and virulence genes. Among the isolates, 46% were positive for intI1, but no isolates carried intI2 or intI3. Eighteen class 1 integrons (21%) contained resistance gene cassettes (i.e. dfrA1-orfC, dfrA12-aadA2, bla(PSE-1) and aadA2) and f...

journal_title：International journal of antimicrobial agents

authors： Wannaprasat W,Padungtod P,Chuanchuen R

更新日期：2011-05-01 00:00:00

abstract：:A total of 300 Streptococcus pyogenes isolates, collected during 2001 from five hospitals in the Thessalia district (Central Greece), were examined for their resistance to macrolides. Resistance to erythromycin was detected in 58 isolates (19.3%). Of these, 68.9% were susceptible to clindamycin (M-phenotype) and carri...

journal_title：International journal of antimicrobial agents

authors： Petinaki E,Kontos F,Pratti A,Skulakis C,Maniatis AN

更新日期：2003-01-01 00:00:00

abstract：:Recent basic and clinical research efforts have shed more light on the taxonomy, microbiology, epidemiology, antimicrobial susceptibility and treatment of Bacteroides, Prevotella, and Porphyromonas species. Of all anaerobic bacteria, Bacteroides is the most frequently isolated pathogen from clinical specimens, includi...

journal_title：International journal of antimicrobial agents

authors： Falagas ME,Siakavellas E

更新日期：2000-06-01 00:00:00

abstract：:Carbapenem-resistant Enterobacteriaceae (CRE) are among the most difficult to treat emerging multidrug-resistant organisms. Major limitations exist in surveillance needed to address CRE, particularly in areas with inadequate resources. We utilised optimised strategies to search for data on carbapenem susceptibility of...

journal_title：International journal of antimicrobial agents

authors： Mitgang EA,Hartley DM,Malchione MD,Koch M,Goodman JL

更新日期：2018-09-01 00:00:00

abstract：:Polymyxins are increasingly used as a last resort for the treatment of infections caused by multidrug-resistant Gram-negative bacteria in patients. Over the last decade, significant progress has been made in understanding the pharmacokinetics/pharmacodynamics/toxicodynamics (PK/PD/TD) of parenteral and inhaled polymyx...

journal_title：International journal of antimicrobial agents

authors： Lin YW,Aye SM,Rao G,Zhou QT,Chan HK,Li J

更新日期：2020-12-01 00:00:00

abstract：:Healthcare resources are being diverted for the containment and control of coronavirus disease 2019 (COVID-19). During this outbreak, it is cautioned that antibiotic misuse may be increased, especially for respiratory tract infections. With stewardship interventions, the duration of antibiotic therapy and length of st...

journal_title：International journal of antimicrobial agents

authors： Liew Y,Lee WHL,Tan L,Kwa ALH,Thien SY,Cherng BPZ,Chung SJ

更新日期：2020-11-01 00:00:00

abstract：:Coxiella burnetii is the bacterial agent of Q fever in humans. Acute Q fever generally manifests as a flu-like illness and is typically self-resolving. In contrast, chronic Q fever usually presents with endocarditis and is often life-threatening without appropriate antimicrobial therapy. Unfortunately, available optio...

journal_title：International journal of antimicrobial agents

authors： Minnick MF,Hicks LD,Battisti JM,Raghavan R

更新日期：2010-10-01 00:00:00

abstract：:Enterococcus faecium is a significant opportunistic human pathogen with a broad host range, including humans, farm animals, pets and wildlife. Specialised subpopulations have globally evolved towards a powerful and convergent adaption to the healthcare environment by acquiring a cocktail of key antimicrobial resistanc...

journal_title：International journal of antimicrobial agents

authors： Freitas AR,Pereira AP,Novais C,Peixe L

更新日期：2021-01-01 00:00:00

abstract：:The activity of amphotericin B, fluconazole, flucytosine, itraconazole and voriconazole was tested in vitro against 618 clinical Candida spp. isolates, using the broth microdilution or the disk diffusion method (voriconazole). Amphotericin B and voriconazole were the most potent antifungal agents assayed (100% of susc...

journal_title：International journal of antimicrobial agents

authors： Gualco L,Debbia EA,Bandettini R,Pescetto L,Cavallero A,Ossi MC,Schito AM,Marchese A

更新日期：2007-02-01 00:00:00

abstract：:Spongistatin 1, a macrocyclic lactone polyether from the marine sponge Hyrtios erecta, was fungicidal for a variety of opportunistic yeasts and filamentous fungi, including strains resistant to amphotericin B, ketoconazole and flucytosine. In broth macrodilution assays, MICs ranged from 0.195 to 12.5 microg/ml, and mi...

journal_title：International journal of antimicrobial agents

authors： Pettit RK,McAllister SC,Pettit GR,Herald CL,Johnson JM,Cichacz ZA

更新日期：1997-01-01 00:00:00

abstract：:Acinetobacter baumannii is an opportunistic pathogen predominantly associated with nosocomial infections. The World Health Organization's data on antibiotic-resistant 'priority pathogens' reports carbapenem-resistant A. baumannii as a pathogen which is in critical need of research and development of new antimicrobials...

journal_title：International journal of antimicrobial agents

authors： Thomas VM,Brown RM,Ashcraft DS,Pankey GA

更新日期：2019-05-01 00:00:00

abstract：:One hundred and seventy-seven strains of Streptococcus pneumoniae derived from respiratory specimens between 1987 and 2001 were evaluated for their antimicrobial susceptibilities and distribution of genes related to penicillin and macrolide resistance. Resistance rates tended to be higher for the 1996-2001 isolates th...

journal_title：International journal of antimicrobial agents

authors： Hiramatsu K,Ohama M,Mijajima Y,Kishi K,Mizunoe S,Tokimatsu I,Nagai H,Kadota J,Saikawa T,Nasu M

更新日期：2004-08-01 00:00:00

abstract：:Using a murine model of disseminated infection by Fusarium verticillioides, the efficacy of liposomal amphotericin (L-AmB) B at 10mg/kg body weight once daily and terbinafine (TRB) at 150 mg/kg body weight twice daily, alone and in combination, was evaluated. The combination of L-AmB with TRB was the only treatment ab...

journal_title：International journal of antimicrobial agents

authors： Ruíz-Cendoya M,Pastor FJ,Capilla J,Guarro J

更新日期：2011-01-01 00:00:00

abstract：:The ongoing seventh cholera pandemic is attributed to Vibrio cholerae O1 El Tor biotype strains. Although antibiotic therapy ameliorates symptoms in patients and reduces pathogen transfer to the environment, multidrug resistance remains a major clinical threat. An O1 El Tor strain isolated from a patient in 1998 was i...

journal_title：International journal of antimicrobial agents

authors： Wang R,Li J,Kan B

更新日期：2016-09-01 00:00:00

abstract：:Growth of Staphylococcus aureus in the presence of salicylate leads to reduced ciprofloxacin and ethidium accumulation and increased resistance to ethidium. Salicylate induced reduction in ciprofloxacin accumulation is energy-independent while salicylate induced alterations in ethidium accumulation and efflux is proto...

journal_title：International journal of antimicrobial agents

authors： Price CT,Kaatz GW,Gustafson JE

更新日期：2002-09-01 00:00:00

abstract：:Infestation with parasitic helminths is a common problem in human populations of third world countries and is ubiquitous in livestock and other domestic animals. The cell-membrane efflux pump, P-glycoprotein (Pgp), appears to contribute to anthelmintic resistance. Pgp have been identified from both phyla of parasitic ...

journal_title：International journal of antimicrobial agents

authors： Kerboeuf D,Blackhall W,Kaminsky R,von Samson-Himmelstjerna G

更新日期：2003-09-01 00:00:00

abstract：:Twenty-five years after its introduction, ceftazidime remains the most active cephalosporin against Pseudomonas aeruginosa. Nevertheless, resistance arises by upregulation of AmpC beta-lactamase, by efflux or, less often, via acquisition of additional beta-lactamases. Mutational resistance is especially prevalent amon...

journal_title：International journal of antimicrobial agents

authors： Livermore DM,Mushtaq S,Ge Y,Warner M

更新日期：2009-11-01 00:00:00

abstract：:The activity of six fluoroquinolones (FQs) was determined against 100 methicillin-resistant Staphylococcus aureus (MRSA) isolated in 2002 along with mutations in the grlA and gyrA genes and in the norA promoter of these isolates. Of the isolates tested, 97% had mutations in grlA and gyrA. A single mutation in grlA and...

journal_title：International journal of antimicrobial agents

authors： Noguchi N,Okihara T,Namiki Y,Kumaki Y,Yamanaka Y,Koyama M,Wakasugi K,Sasatsu M

更新日期：2005-05-01 00:00:00

abstract：:Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) is a frequent cause of acute pyelonephritis (APN), requiring carbapenem therapy. However, alternatives to carbapenems are needed due to the emergence of carbapenemase-producing micro-organisms. The purpose of this study was to compare the clinical effi...

journal_title：International journal of antimicrobial agents

authors： Yoon YK,Kim JH,Sohn JW,Yang KS,Kim MJ

更新日期：2017-04-01 00:00:00

abstract：:Norfloxacin is the first in a series of new 4-quinolones that have been introduced into medical practice for the treatment of bacterial infections. This totally synthetic compound is a broad spectrum, bactericidal agent that is much more potent than the earlier analogs, i.e. nalixidic acid, pipemidic acid, cinoxacin, ...

journal_title：International journal of antimicrobial agents

authors： Gadebusch HH,Shungu DL

更新日期：1991-01-01 00:00:00

abstract：:In this study, we analysed the antimicrobial susceptibility of 92 strains of Achromobacter spp. isolated from clinical samples to 18 antimicrobial agents. The disk diffusion method and Etest were compared with the agar dilution method, and the breakpoints of susceptibility and resistance for the disk diffusion method ...

journal_title：International journal of antimicrobial agents

authors： Almuzara M,Limansky A,Ballerini V,Galanternik L,Famiglietti A,Vay C

更新日期：2010-01-01 00:00:00

abstract：:To compare the antimicrobial effects (AMEs) of two quinolones in terms of the AUC/MIC- and dose (D)-response relationships, five differentially susceptible clinical isolates of Pseudomonas aeruginosa were exposed to decreasing concentrations of ciprofloxacin (two 12-h doses with T(1/2) = 4 h) and trovafloxacin (a sing...

journal_title：International journal of antimicrobial agents

authors： Lubenko IY,Vostrov SN,Portnoy YA,Zinner SH,Firsov AA

更新日期：2002-07-01 00:00:00

abstract：:The comparative safety of azithromycin was assessed in adult patients (> or =12 years) with community-acquired respiratory tract infections. Of 3229 patients evaluated, 1616 received azithromycin 500 mg once daily for 3 days and 1613 received standard regimens of amoxycillin, amoxycillin/clavulanic acid, cefaclor, cla...

journal_title：International journal of antimicrobial agents

authors： Treadway G,Pontani D,Reisman A

更新日期：2002-03-01 00:00:00

abstract：:S fimbrial adhesins (Sfa) represent virulence factors of E. coli wild-type strains causing urinary tract infections and meningitis of the new born. In order to determine the influence of subinhibitory concentration of antibiotics on the expression of the sfa gene cluster, a wild-type strain carrying the lacZ gene, cod...

journal_title：International journal of antimicrobial agents

authors： Hacker J,Ott M,Hof H

更新日期：1993-01-01 00:00:00

abstract：:There is strong evidence that self-monitoring and feedback are effective behaviour change techniques (BCTs) across a range of healthcare interventions and that their effectiveness is enhanced by goal setting and action planning. Here we report a summary of the update of a systematic review assessing the application of...

journal_title：International journal of antimicrobial agents

authors： Davey P,Peden C,Charani E,Marwick C,Michie S

更新日期：2015-03-01 00:00:00

abstract：:The proline-rich antimicrobial peptide oncocin is remarkably active in vitro against a number of important Gram-negative bacteria of concern to humans owing to their increasing resistance to antibiotics, i.e. Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacae) and non-fermenting speci...

journal_title：International journal of antimicrobial agents

authors： Knappe D,Kabankov N,Hoffmann R

更新日期：2011-02-01 00:00:00

abstract：:In vitro and in vivo anti-Candida albicans and anti-Aspergillus fumigatus activities of NND-502, a new imidazole-antimycotic, were compared with those of fluconazole (FCZ), itraconazole (ITZ) and/or amphotericin B (AmB). NND-502 exhibited strong in vitro antifungal activity against both fungal species; its MIC against...

journal_title：International journal of antimicrobial agents

authors： Niwano Y,Kuzuhara N,Goto Y,Munechika Y,Kodama H,Kanai K,Yoshida M,Miyazaki T,Yamaguchi H

更新日期：1999-08-01 00:00:00

abstract：:Piperacillin plasma concentrations are known to vary between critically ill patients. However, there are no comprehensive data on the variability of antibiotic concentrations within the same patient. The purpose of this study was to investigate the adequacy of dosing during an entire 7-day antibiotic course and to inv...

journal_title：International journal of antimicrobial agents

authors： Carlier M,Carrette S,Stove V,Verstraete AG,De Waele JJ

更新日期：2014-05-01 00:00:00

abstract：:In an open-label emergency-use study, 23 patients with bacterial infections caused by multiply drug resistant pathogens were treated with clinafloxacin. Efficacy and safety were evaluated by tabulating investigators' assessments at the end of treatment, treatment discontinuations and adverse event data. Most of the pa...

journal_title：International journal of antimicrobial agents

authors： Shah P,Trostmann U,Tack K

更新日期：2002-03-01 00:00:00

abstract：:Resistance to chemotherapy is a common clinical problem in patients with infectious diseases as well as in patients with cancer. During treatment of infections or malignant tumors, the drug targets of prokaryotic or eukaryotic microorganisms and neoplastic cells are often found to be refractory to a variety of drugs t...

journal_title：International journal of antimicrobial agents

authors： Lage H

更新日期：2003-09-01 00:00:00