Abstract：
:The management of some serious infections such as infective endocarditis (IE) and bone and joint infections (BJIs) caused by Gram-positive cocci (GPC) is complex and requires great responsiveness and effective antimicrobials with high bioavailability in heart valves or bone tissues. Treatment of these infections requires the use of a higher dosage that may result in increased toxicity or the use of new promising antimicrobials to control the infection. However, use of these new antimicrobials could still bring about new toxicity and resistance. Another approach may be the 'comeback' of old antimicrobials, which is evaluated in this review in the treatment of IE and BJIs caused by GPC.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Seng P,Amrane S,Million M,Stein Adoi
10.1016/j.ijantimicag.2017.03.004subject
Has Abstractpub_date
2017-05-01 00:00:00pages
558-564issue
5eissn
0924-8579issn
1872-7913pii
S0924-8579(17)30098-5journal_volume
49pub_type
杂志文章,评审abstract：:The purpose of this study was (i) to determine the optimal dosage of teicoplanin for each patient group stratified by renal function and weight based on a population pharmacokinetic model and observed distribution of patient characteristics and (ii) to develop new simplified dosing regimens designed to achieve 15-30 μ...
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journal_title：International journal of antimicrobial agents
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journal_title：International journal of antimicrobial agents
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journal_title：International journal of antimicrobial agents
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journal_title：International journal of antimicrobial agents
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journal_title：International journal of antimicrobial agents
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