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In vitro activities of small peptides from snake venom against clinical isolates of drug-resistant Mycobacterium tuberculosis.

Abstract：

:The recent re-emergence of tuberculosis, especially the multidrug-resistant cases, has highlighted the importance of screening effective novel drugs against Mycobacterium tuberculosis. In this study, the in vitro activities of small peptides isolated from snake venom were investigated against multidrug-resistant M. tuberculosis. Minimum inhibitory concentrations (MICs) were determined by the Bactec TB-460 radiometric method. A small peptide with the amino acid sequence ECYRKSDIVTCEPWQKFCYREVTFFPNHPVYLSGCASECTETNSKWCCTTDKCNRARGG (designated as vgf-1) from Naja atra (isolated from Yunnan province of China) venom had in vitro activity against clinically isolated multidrug-resistant strains of M. tuberculosis. The MIC was 8.5 mg/l. The antimycobacterial domain of this 60aa peptide is under investigation.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Xie JP,Yue J,Xiong YL,Wang WY,Yu SQ,Wang HH

doi

10.1016/s0924-8579(03)00110-9

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

172-4

issue

2

eissn

0924-8579

issn

1872-7913

pii

S0924857903001109

journal_volume

22

pub_type

杂志文章

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