Abstract：
UNLABELLED:DNA microarray technology has been used for genome-wide gene expression studies that incorporate molecular genetics and computer science skills on massive levels. The technology permits the simultaneous analysis of tens of thousands of genes for the purposes of gene discovery, disease diagnosis. improved drug development, and therapeutics tailored to specific disease processes. OBJECTIVE:In this review, the two most common microarray technologies and their potential application to dental research will be discussed. The authors review current articles pertaining to the technologies and analysis of mRNA expression using DNA micro-arrays and its application to dental research. Since many genes contribute to normal functioning, research efforts are moving from the search for a disease specific gene to the understanding of the biochemical and molecular functioning of a variety of genes and how complicated networks of interaction can lead to a disease state, such as oral cancer. With the incorporation of DNA micro-array based research, we can look forward to more accurate diagnosis and surgical treatment/drug-delivery therapy based on an individual patient's genetic profile.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Kuo WP,Whipple ME,Sonis ST,Ohno-Machado L,Jenssen TKdoi
10.1016/s1368-8375(02)00013-1subject
Has Abstractpub_date
2002-10-01 00:00:00pages
650-6issue
7eissn
1368-8375issn
1879-0593pii
S1368-8375(02)00013-1journal_volume
38pub_type
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