Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity.

Abstract:

:Toll and related proteins play important roles in innate immunity in both invertebrates and vertebrates. In Drosophila melanogaster, Tehao shares a striking similarity in its intracellular domain with Toll. In this paper, we show that Tehao is expressed throughout development and appears to be glycosylated. In transiently transfected cells, Tehao activated both Dorsal and the transcription of endogenous drosomycin and metchnikowin genes. Purified recombinant Tehao interacted specifically in vitro not only with the Pelle protein kinase, but also with the Toll intracytoplasmic domain. Remarkably, Tehao was found to activate Dorsal-dependent transcription in a synergistic manner with Toll, as well as Pelle in co-transfected cells. Thus, Tehao, alone or with Toll as a multimeric complex, has the potential to participate in both the development and innate immune responses of Drosophila.

journal_name

Insect Mol Biol

journal_title

Insect molecular biology

authors

Luo C,Shen B,Manley JL,Zheng L

doi

10.1046/j.0962-1075.2001.00284.x

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

457-64

issue

5

eissn

0962-1075

issn

1365-2583

pii

284

journal_volume

10

pub_type

杂志文章
  • Functional characterization of Musca glutamate- and GABA-gated chloride channels expressed independently and coexpressed in Xenopus oocytes.

    abstract::Ligand-gated chloride channels (LGICs) are important targets for insecticides and parasiticides. Genes encoding subunits of two LGICs, a glutamate-gated chloride channel (MdGluCl-alpha) and a gamma-aminobutyric acid (GABA)-gated chloride channel (MdRdl), were cloned from house-flies (Musca domestica L.). These genes w...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.2006.00680.x

    authors: Eguchi Y,Ihara M,Ochi E,Shibata Y,Matsuda K,Fushiki S,Sugama H,Hamasaki Y,Niwa H,Wada M,Ozoe F,Ozoe Y

    更新日期:2006-12-01 00:00:00

  • Induction of the white egg 3 mutant phenotype by injection of the double-stranded RNA of the silkworm white gene.

    abstract::Injection of double-stranded RNA (dsRNA) corresponding to the silkworm white gene (Bmwh3) into preblastoderm eggs of the wild-type silkworm induced phenotypes similar to those observed with mutants of the white egg 3 locus (10-19.6). The induced phenotypes were characterized by the presence of white eggs and transluce...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2583.2002.00328.x

    authors: Quan GX,Kanda T,Tamura T

    更新日期:2002-06-01 00:00:00

  • Middle region of FancM interacts with Mhf and Rmi1 in silkworms, a species lacking the Fanconi anaemia (FA) core complex.

    abstract::The Fanconi anaemia (FA) pathway is responsible for interstrand crosslink (ICL) repair. Among the FA core complex components, FANCM is believed to act as a damage sensor for the ICL-blocked replication fork and also as a molecular platform for FA core complex assembly and interaction with Bloom's syndrome (BS) complex...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/imb.12072

    authors: Sugahara R,Mon H,Lee JM,Kusakabe T

    更新日期:2014-04-01 00:00:00

  • Five major subfamilies of mariner transposable elements in insects, including the Mediterranean fruit fly, and related arthropods.

    abstract::We have used a PCR assay to screen 404 insects and related arthropods for mariner elements using primers corresponding to amino acids conserved between the mariner elements of Drosophila mauritiana and a moth, Hyalophora cecropia. Potential mariner elements were detected in sixty-three species, representing ten insect...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.1993.tb00132.x

    authors: Robertson HM,MacLeod EG

    更新日期:1993-01-01 00:00:00

  • Levels and activity of cyclic guanosine monophosphate-dependent protein kinase in nurse and forager honeybees.

    abstract::Age-dependent division of labour in honeybees was shown to be connected to sensory response thresholds. Foragers show a higher gustatory responsiveness than nurse bees. It is generally assumed that nutrition-related signalling pathways underlie this behavioural plasticity. Here, one important candidate gene is the for...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/imb.12520

    authors: Thamm M,Sturm K,Schlossmann J,Scheiner R

    更新日期:2018-12-01 00:00:00

  • Insect glutathione transferases and insecticide resistance.

    abstract::Glutathione transferases (GSTs) are a diverse family of enzymes found ubiquitously in aerobic organisms. They play a central role in the detoxification of both endogenous and xenobiotic compounds and are also involved in intracellular transport, biosynthesis of hormones and protection against oxidative stress. Interes...

    journal_title:Insect molecular biology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2583.2004.00529.x

    authors: Enayati AA,Ranson H,Hemingway J

    更新日期:2005-01-01 00:00:00

  • The expression of the HSP90 gene in response to winter and summer diapauses and thermal-stress in the onion maggot, Delia antiqua.

    abstract::The full-length Hsp90 cDNA in Delia antiqua was cloned and sequenced. The deduced polypeptide comprised 717 amino acid residues, with a molecular mass of 82 140 Da. Summer- and winter-diapauses both elevated HSP90 transcript levels in D. antiqua pupae. Levels gradually increased with time in summer diapausing pupae wh...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.2005.00602.x

    authors: Chen B,Kayukawa T,Monteiro A,Ishikawa Y

    更新日期:2005-12-01 00:00:00

  • Molecular basis for odorant receptor tuning: a short C-terminal sequence is necessary and sufficient for selectivity of mosquito Or8.

    abstract::A birth-and-death evolutionary model for odorant receptor gene repertoires presumes the creation of repertoires with the capacity for high-level diversity and rapid ligand specificity change. This changes the recognised odour space, directly affecting fitness-related behaviours and ultimately affecting adaptation to n...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/imb.12176

    authors: Hill SR,Majeed S,Ignell R

    更新日期:2015-08-01 00:00:00

  • Identification and molecular characterization of a novel protein Saglin as a target of monoclonal antibodies affecting salivary gland infectivity of Plasmodium sporozoites.

    abstract::Molecular mechanisms underlying the interaction between malarial sporozoites and putative receptor(s) on the salivary glands of Anopheles gambiae remain largely unknown. In previous studies, a salivary gland protein of ~100 kDa was identified as a putative target based on recognition of the protein by a monoclonal ant...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.2007.00765.x

    authors: Okulate MA,Kalume DE,Reddy R,Kristiansen T,Bhattacharyya M,Chaerkady R,Pandey A,Kumar N

    更新日期:2007-12-01 00:00:00

  • Molecular characterization of the Anopheles gambiae 2L telomeric region via an integrated transgene.

    abstract::A Drosophila P-element derivative (pUChsneo) integrated into the telomeric region of the left arm of the second chromosome of Anopheles gambiae was used to clone the proximally flanking An. gambiae sequences. Molecular analyses revealed that the pUChsneo construct was partially duplicated and had integrated into a sub...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.1996.tb00035.x

    authors: Biessmann H,Donath J,Walter MF

    更新日期:1996-02-01 00:00:00

  • Neuropeptide Y-like signalling and nutritionally mediated gene expression and behaviour in the honey bee.

    abstract::Previous research has led to the idea that derived traits can arise through the evolution of novel roles for conserved genes. We explored whether neuropeptide Y (NPY)-like signalling, a conserved pathway that regulates food-related behaviour, is involved in a derived, nutritionally-related trait, the division of labou...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.2011.01068.x

    authors: Ament SA,Velarde RA,Kolodkin MH,Moyse D,Robinson GE

    更新日期:2011-06-01 00:00:00

  • Differential regulation of ribosomal protein gene expression in Aedes aegypti mosquitoes before and after the blood meal.

    abstract::In fat body of the mosquito, Aedes aegypti, a cycle of ribosome accumulation and degradation accompanies synthesis of the yolk protein precursor, vitellogenin. Here we compare the transcription and translation of ribosomal proteins rpS6, rpL8 and rpL34, relative to rRNA and vitellogenin genes in Aedes aegypti fat body...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2583.2000.00226.x

    authors: Niu LL,Fallon AM

    更新日期:2000-12-01 00:00:00

  • Identification and isolation of cDNA clones encoding the abundant secreted proteins in the saliva proteome of Culicoides nubeculosus.

    abstract::Culicoides spp. are vectors of several infectious diseases of veterinary importance and a major cause of allergy in horses and other livestock. Their saliva contains a number of proteins which enable blood feeding, enhance disease transmission and act as allergens. We report the construction of a novel cDNA library fr...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.2009.00882.x

    authors: Russell CL,Heesom KJ,Arthur CJ,Helps CR,Mellor PS,Day MJ,Torsteinsdottir S,Björnsdóttir TS,Wilson AD

    更新日期:2009-06-01 00:00:00

  • Isolation of seven unique biogenic amine receptor clones from the honey bee by library scanning.

    abstract::The biogenic amine receptor genes constitute an ancient and highly divergent family within the larger superfamily of G-protein-coupled receptors. These receptors play a central role in modulating nerve cell activity and thus behaviour. Because the honey bee offers numerous advantages for behavioural studies we endeavo...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2583.1998.72059.x

    authors: Ebert PR,Rowland JE,Toma DP

    更新日期:1998-05-01 00:00:00

  • Precise excision and transposition of piggyBac in pink bollworm embryos.

    abstract::Transposable elements such as P, hobo, Hermes, mariner and Minos have been successfully harnessed as gene vectors to achieve the transformation of several dipteran species including Drosophila melanogaster, Ceratitis capitata and Aedes aegypti. Plasmid-based excision and transposition assays have been useful indicator...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2583.1999.810119.x

    authors: Thibault ST,Luu HT,Vann N,Miller TA

    更新日期:1999-02-01 00:00:00

  • Compatible interaction with its rice host leads to enhanced expression of the gamma subunit of oligosaccharyl transferase in the Asian rice gall midge, Orseolia oryzae.

    abstract::The Asian rice gall midge, Orseolia oryzae, is a fast evolving, damaging pest of rice. Understanding the underlying molecular mechanism of interaction between the gall midge and rice will help in devising strategies to control and manage the pest. The present study aims to identify rice-responsive genes in the gall mi...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.2011.01085.x

    authors: Sinha DK,Bentur JS,Nair S

    更新日期:2011-10-01 00:00:00

  • Homing endonucleases catalyze double-stranded DNA breaks and somatic transgene excision in Aedes aegypti.

    abstract::Aedes aegypti is a major vector of arthropod-borne viruses such as yellow fever virus and dengue viruses. Efforts to discern the function of genes involved in important behaviours, such as vector competence and host seeking through reverse genetics, would greatly benefit from the ability to generate targeted gene disr...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.2009.00905.x

    authors: Traver BE,Anderson MA,Adelman ZN

    更新日期:2009-10-01 00:00:00

  • Identification, characterization and expression of a receptor for the unusual myosuppressin in the blood-feeding bug, Rhodnius prolixus.

    abstract::Myosuppressins are a family of the FMRFamide-like peptides. They have been characterized in many insects and shown to inhibit visceral muscle contraction. Rhodnius prolixus possesses an unusual myosuppressin in that the typical FLRFamide C-terminal motif is unique and ends with FMRFamide. In the present study, we isol...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/imb.12141

    authors: Lee D,James TE,Lange AB

    更新日期:2015-02-01 00:00:00

  • Evolutionary variation in gene expression is associated with dimorphism in eusocial vespid wasps.

    abstract::Phenotypic diversity is frequently generated by differences in gene expression. In this study, we addressed the relationship between homology in gene expression and phenotype among four species of eusocial wasps. Specifically, we investigated the evolution of caste-specific and sex-specific gene expression patterns as...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.2010.01021.x

    authors: Hunt BG,Goodisman MA

    更新日期:2010-10-01 00:00:00

  • Specific developmental gene silencing in the honey bee using a homeobox motif.

    abstract::Manipulating the expression of genes in species that are not currently used as genetic models will provide comparative insights into the evolution of gene functions. However the experimental tools in doing so are limited in species that have not served as models for genetic studies. We have examined the effects of dou...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2583.2002.00361.x

    authors: Beye M,Härtel S,Hagen A,Hasselmann M,Omholt SW

    更新日期:2002-12-01 00:00:00

  • Cloning of a family of serine protease genes from the cat flea Ctenocephalides felis.

    abstract::Serine protease gene fragments approximately 480 nucleotides in length were amplified from Ctenocephalides felis larval and adult cDNA libraries using degenerate oligonucleotide PCR primers. Partial clones of thirty-eight distinct serine protease encoding sequences were isolated, and nineteen different full-length cDN...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2583.1999.810011.x

    authors: Gaines PJ,Sampson CM,Rushlow KE,Stiegler GL

    更新日期:1999-02-01 00:00:00

  • Antennal esterase cDNAs from two pest moths, Spodoptera littoralis and Sesamia nonagrioides, potentially involved in odourant degradation.

    abstract::Rapid degradation of odours after interaction with olfactory receptors is a critical step of the signal reception process. However, the implied mechanisms are still largely unknown in vertebrates as well as in insects. Involvement of odourant-degrading enzymes in odourant degradation within the antennae has been shown...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.2006.00702.x

    authors: Merlin C,Rosell G,Carot-Sans G,François MC,Bozzolan F,Pelletier J,Jacquin-Joly E,Guerrero A,Maïbèche-Coisne M

    更新日期:2007-02-01 00:00:00

  • The D7 family of salivary proteins in blood sucking diptera.

    abstract::The D7 subfamily of salivary proteins is widespread in blood sucking Diptera and belongs to the superfamily of pheromone/odourant binding proteins. Although D7 proteins are among the most abundant salivary proteins in adult female mosquitoes and sand flies, their role in blood feeding remains elusive. In the present w...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2583.2002.00319.x

    authors: Valenzuela JG,Charlab R,Gonzalez EC,de Miranda-Santos IK,Marinotti O,Francischetti IM,Ribeiro JM

    更新日期:2002-04-01 00:00:00

  • Transcriptome analysis of the cowpea weevil bruchid: identification of putative proteinases and alpha-amylases associated with food breakdown.

    abstract::We describe here the first systematic work to discover insect genes involved in food breakdown using a cDNA library enriched for gut-expressed transcripts from Callosobruchus maculatus. A total of 1056 clones were screened for cDNA insert-containing plasmids, and 503 nonredundant open reading frames were discovered. T...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2583.2003.00425.x

    authors: Pedra JH,Brandt A,Westerman R,Lobo N,Li HM,Romero-Severson J,Murdock LL,Pittendrigh BR

    更新日期:2003-08-01 00:00:00

  • Molecular analysis of a mutant Anticarsia gemmatalis multiple nucleopolyhedrovirus (AgMNPV) shows an interruption of an inhibitor of apoptosis gene (iap-3) by a new class-II piggyBac-related insect transposon.

    abstract::A new piggyBac-related transposable element (TE) was found in the genome of a mutant Anticarsia gemmatalis multiple nucleopolyhedrovirus interrupting an inhibitor of apoptosis gene. This mutant virus induces apoptosis upon infection of an Anticarsia gemmatalis cell line, but not in a Trichoplusia ni cell line. The seq...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.2009.00917.x

    authors: Carpes MP,Nunes JF,Sampaio TL,Castro ME,Zanotto PM,Ribeiro BM

    更新日期:2009-11-01 00:00:00

  • Raalin, a transcript enriched in the honey bee brain, is a remnant of genomic rearrangement in Hymenoptera.

    abstract::We identified a predicted compact cysteine-rich sequence in the honey bee genome that we called 'Raalin'. Raalin transcripts are enriched in the brain of adult honey bee workers and drones, with only minimum expression in other tissues or in pre-adult stages. Open-reading frame (ORF) homologues of Raalin were identifi...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.2012.01138.x

    authors: Tirosh Y,Morpurgo N,Cohen M,Linial M,Bloch G

    更新日期:2012-06-01 00:00:00

  • Homeodomain-interacting protein kinase (Hipk) phosphorylates the small SPOC family protein Spenito.

    abstract::The Drosophila homeodomain-interacting protein kinase (Hipk) is a versatile regulator involved in a variety of pathways, such as Notch and Wingless signalling, thereby acting in processes including the promotion of eye development or control of cell numbers in the nervous system. In vertebrates, extensive studies have...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/imb.12117

    authors: Dewald DN,Steinmetz EL,Walldorf U

    更新日期:2014-12-01 00:00:00

  • Microarray analysis of genes showing variable expression following a blood meal in Anopheles gambiae.

    abstract::A microarray analysis of 14 900 genes of the malaria vector mosquito, Anopheles gambiae, shows that as many as 33% (4924) of their corresponding transcription products vary in abundance within 24 h after a blood meal. Approximately half (2388) of these products increase in their accumulation and the remainder (2536) d...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.2005.00567.x

    authors: Marinotti O,Nguyen QK,Calvo E,James AA,Ribeiro JM

    更新日期:2005-08-01 00:00:00

  • Physiological significance of alternatively spliced exon combinations of the single-copy gene class A chitin synthase in the insect Ostrinia furnacalis (Lepidoptera).

    abstract::Insect chitin synthase is an essential enzyme involved in chitin biosynthesis in insects. Chitin synthase A (CHSA) is expressed in different insect tissues during different developmental stages. CHSA contains alternative-splicing exons that allow tissue- and development-specific chitin synthesis. Here, we report that ...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.2012.01145.x

    authors: Qu M,Yang Q

    更新日期:2012-08-01 00:00:00

  • Characterization and expression of the odorant-binding protein 7 gene in Anopheles stephensi and comparative analysis among five mosquito species.

    abstract::Odorant-binding proteins (OBPs) are important molecular players in insect olfaction, which has a great influence on the host-seeking behaviour of mosquitoes and other disease vectors. The mRNA level of the Anopheles gambiae Obp7 gene (Agam-Obp7) is higher in the adult female antennae and is slightly reduced in the fem...

    journal_title:Insect molecular biology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2583.2008.00837.x

    authors: Sengul MS,Tu Z

    更新日期:2008-12-01 00:00:00