Insect glutathione transferases and insecticide resistance.

Abstract:

:Glutathione transferases (GSTs) are a diverse family of enzymes found ubiquitously in aerobic organisms. They play a central role in the detoxification of both endogenous and xenobiotic compounds and are also involved in intracellular transport, biosynthesis of hormones and protection against oxidative stress. Interest in insect GSTs has primarily focused on their role in insecticide resistance. GSTs can metabolize insecticides by facilitating their reductive dehydrochlorination or by conjugation reactions with reduced glutathione, to produce water-soluble metabolites that are more readily excreted. In addition, they contribute to the removal of toxic oxygen free radical species produced through the action of pesticides. Annotation of the Anopheles gambiae and Drosophila melanogaster genomes has revealed the full extent of this enzyme family in insects. This mini review describes the insect GST enzyme family, focusing specifically on their role in conferring insecticide resistance.

journal_name

Insect Mol Biol

journal_title

Insect molecular biology

authors

Enayati AA,Ranson H,Hemingway J

doi

10.1111/j.1365-2583.2004.00529.x

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

3-8

issue

1

eissn

0962-1075

issn

1365-2583

pii

IMB529

journal_volume

14

pub_type

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