Abstract:
:Glutathione transferases (GSTs) are a diverse family of enzymes found ubiquitously in aerobic organisms. They play a central role in the detoxification of both endogenous and xenobiotic compounds and are also involved in intracellular transport, biosynthesis of hormones and protection against oxidative stress. Interest in insect GSTs has primarily focused on their role in insecticide resistance. GSTs can metabolize insecticides by facilitating their reductive dehydrochlorination or by conjugation reactions with reduced glutathione, to produce water-soluble metabolites that are more readily excreted. In addition, they contribute to the removal of toxic oxygen free radical species produced through the action of pesticides. Annotation of the Anopheles gambiae and Drosophila melanogaster genomes has revealed the full extent of this enzyme family in insects. This mini review describes the insect GST enzyme family, focusing specifically on their role in conferring insecticide resistance.
journal_name
Insect Mol Bioljournal_title
Insect molecular biologyauthors
Enayati AA,Ranson H,Hemingway Jdoi
10.1111/j.1365-2583.2004.00529.xsubject
Has Abstractpub_date
2005-01-01 00:00:00pages
3-8issue
1eissn
0962-1075issn
1365-2583pii
IMB529journal_volume
14pub_type
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1111/imb.12602
更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2583.2010.01064.x
更新日期:2011-04-01 00:00:00
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journal_title:Insect molecular biology
pub_type: 杂志文章
doi:10.1111/imb.12305
更新日期:2017-08-01 00:00:00
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journal_title:Insect molecular biology
pub_type: 杂志文章
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journal_title:Insect molecular biology
pub_type: 杂志文章
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journal_title:Insect molecular biology
pub_type: 杂志文章
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更新日期:2003-12-01 00:00:00
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