Gene structure and expression of nanos (nos) and oskar (osk) orthologues of the vector mosquito, Culex quinquefasciatus.

Abstract:

:The products of the maternal-effect genes, nanos (nos) and oskar (osk), are important for the development of germ cells in insects. Furthermore, these genes have been proposed as candidates for donating functional DNA regulatory sequences for use in gene drive systems to control transmission of mosquito-borne pathogens. The nos and osk genes of the cosmopolitan vector mosquito, Culex quinquefasciatus, encode proteins with domains common to orthologues found in other mosquitoes. Expression analyses support the conclusion that the role of these genes is conserved generally among members of the nematocera. Hybridization in situ analyses reveal differences in mRNA distribution in early embryos in comparison with the cyclorraphan, Drosophila melanogaster, highlighting a possible feature in the divergence of the clades each insect represents.

journal_name

Insect Mol Biol

journal_title

Insect molecular biology

authors

Juhn J,Marinotti O,Calvo E,James AA

doi

10.1111/j.1365-2583.2008.00823.x

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

545-52

issue

5

eissn

0962-1075

issn

1365-2583

pii

IMB823

journal_volume

17

pub_type

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