Abstract：
OBJECTIVE:To determine if gabapentin is effective in monotherapy or add-on treatment of non-refractory bipolar disorder in open prospective treatment. METHODS:Charts of 21 outpatients meeting DSM-IV criteria for bipolar spectrum disorder (type I, type II, NOS, and cyclothymia) and who were treated with gabapentin were reviewed and clinical response was assessed based on prospective application of the Hamilton Depression Rating Scale (HDRS), the Young Mania Rating Scale (YMRS), the Clinical Global Impression scale (CGI), and the Global Assessment of Functioning scale (GAF). Also, response was rated retrospectively using the Clinical Global Impression scale for Bipolar Disorder (CGI-BP). RESULTS:Eight patients received gabapentin monotherapy and 13 received adjunctive therapy. Similar improvement in depression was noted in the monotherapy group, without induction of mania. Gabapentin was associated with a 43.8% improvement in manic symptoms and a 27.6% improvement in depressive symptoms in the overall sample. In the depressed subsample (n=10), there was a 57.5% improvement in depressive symptoms (P=0.10). Using the CGI-BP, gabapentin was moderately to markedly effective in 43% of patients for overall bipolar illness, 38% for depressive symptoms, and 25% for manic symptoms. Of those in the study, 62% reported side effects, mainly sedation and nausea, with 14% of the total sample discontinuing treatment due to adverse events. CONCLUSIONS:Gabapentin, either alone or as an adjunct, appeared moderately effective in treating depression in this small, uncontrolled, heterogeneous sample of non-refractory bipolar spectrum illness. Coupled with the earlier clinical literature, these data suggest the need for prospective double-blind studies of depressive illness in the bipolar spectrum.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Ghaemi SN,Goodwin FKdoi
10.1016/s0165-0327(00)00218-4subject
Has Abstractpub_date
2001-07-01 00:00:00pages
167-71issue
2eissn
0165-0327issn
1573-2517pii
S0165032700002184journal_volume
65pub_type
杂志文章abstract：:The new ICD-10 categories of 'depressive episode' (F32) and 'recurrent depressive disorder' (F33) were evaluated on the levels of diagnoses, subtypes, syndromes and symptoms. Interrater reliability was analyzed from findings of four independent diagnosticians who rated 100 written psychiatric case records with the hel...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(94)90126-0
更新日期：1994-05-01 00:00:00
abstract：:Current formal psychiatric approaches to nosology are plagued by an unwieldy degree of heterogeneity with insufficient appreciation of the commonalities of emotional, personality, behavioral, and addictive disorders. We address this challenge by building a spectrum model that integrates the advantages of Cloninger's a...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2006.02.025
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:China's HIV epidemic commenced in its agrarian provinces through contaminated commercial plasma donation centers and is now becoming a public health concern nationwide. Little is known of the psychiatric and substance use disorder characteristics of this population, or their impact on everyday function, empl...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2010.10.039
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:We examined the performance the Beck Depression Inventory (BDI) and its short form (BDI-FS) and the Hospital Anxiety and Depression Scale depression (HADS-D) and anxiety (HADS-A) subscales in detecting depression in a group of patients with hepatitis C. METHODS:SCID-CV was used to establish DSM-IV diagnosis...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2006.10.020
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:This study examines comorbidity of posttraumatic stress disorder (PTSD) and depression following myocardial infarction (MI). It has two aims: (a) to examine whether this comorbidity is predicted by the objective severity of the MI and the patients' initial appraisal and stress responses; and (b) to determine...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2006.03.016
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:Ketamine induces rapid and robust antidepressant effects, and many patients also describe dissociation, which is associated with antidepressant response. This follow-up study investigated whether antidepressant efficacy is uniquely related to dissociative symptom clusters. METHODS:Treatment-resistant patien...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
doi：10.1016/j.jad.2018.02.049
更新日期：2018-05-01 00:00:00
abstract：UNLABELLED:Biased inhibitory processing, frequency and valence of automatic thoughts, and inability to use positive schemas to regulate negative mood are cognitive factors linked to depression. These processes may underlie the established link between adaptive cognitive coping strategies (acceptance and positive refram...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.05.014
更新日期：2013-09-25 00:00:00
abstract：:The two diagnostic Newcastle Scales for depression have been evaluated in a drug trial with antidepressants. By use of latent structure analysis (Rasch models) it was found that two dimensions are necessary for describing the diagnosis of depression, one for endogenous features and one for reactive features. Of the de...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
doi：10.1016/0165-0327(88)90059-6
更新日期：1988-03-01 00:00:00
abstract：BACKGROUND:Circadian rhythm disturbances have been reported in patients with major depressive disorder (MDD). Among these is an increased phase angle between peak cortisol concentration and dim-light melatonin onset (DLMO). The aim of this study was to evaluate changes in chronobiologic parameters of sleep in patients ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.09.026
更新日期：2021-01-01 00:00:00
abstract：:The comparison of polysomnographic data between a group of nine major depressive adolescents, 12 minor depressive adolescents and 12 controls showed a significant difference in sleep efficiency index and in percentage of awakenings. Sleep efficiency was reduced in major depressive adolescents and the percentage of awa...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(88)90069-9
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:Vital statistics on the number of, alcohol-induced death (AICD) drug-induced death (DICD), and suicides at the local-level are only available after a substantial lag of up to two years after the events occur. We (1) investigate how well Google Trends search data explain variation in state-level rates in the ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.10.038
更新日期：2017-04-15 00:00:00
abstract：BACKGROUND:The maternity blues have been studied world-wide and are generally regarded as a cross-cultural phenomenon. However, low prevalence rates of the blues have been reported recently in studies of Japanese women. The purposes of this study are, firstly, to establish whether the low prevalence noted in Japanese w...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(02)00039-3
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND:Although the clinical efficacy of electroconvulsive therapy (ECT) is well established, the underlying mechanisms of action remain elusive. The aim of this study was to elucidate structural changes of the brain following ECT in patients with major depressive disorder (MDD). METHOD:Fifteen patients with MDD u...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.06.051
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Little is known about medical comorbidity or health-related quality of life (HRQOL) in bipolar disorder across the adult age span, especially in public sector patients. METHODS:We obtained cross-sectional demographic, clinical, and functional ratings for 330 veterans hospitalized for bipolar disorder with M...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2004.12.006
更新日期：2005-05-01 00:00:00
abstract：:Mental disorders among suicide victims who had suffered from cancer were investigated using psychological autopsy data on all suicides in Finland over 1 year. Retrospective DSM-III-R consensus diagnoses were assigned to all 60 cancer suicides and to 60 age- and sex-matched comparison suicides without a cancer history....
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(95)00047-x
更新日期：1995-12-24 00:00:00
abstract：:Thirteen patients with major depressive disorder, 25 patients with dysthymia and 12 healthy controls underwent ergopsychometric testing. The effect of self-paced and set-paced load on mood, vigilance and perseveration tendency was recorded. Within the clinical groups, various types of load seemed to result mainly in v...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(91)90095-a
更新日期：1991-10-01 00:00:00
abstract：:Computed axial brain tomography was studied in 25 patients with panic disorder. Patients had normal ventricular-brain ratio (VBR) compared to published norms. There was a significant association between VBR and duration of benzodiazepine use. ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(87)90011-5
更新日期：1987-03-01 00:00:00
abstract：BACKGROUND:The association between loneliness and suicide is poorly understood. We investigated how living alone, loneliness and emotional support were related to suicide and self-harm in a longitudinal design. METHODS:Between 2006 and 2010 UK Biobank recruited and assessed in detail over 0.5 million people in middle ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.10.026
更新日期：2021-01-15 00:00:00
abstract：BACKGROUND:Previous studies have indicated that obsessive-compulsive disorder (OCD) might have a reduced placebo response compared to other anxiety-related disorders including generalized anxiety disorder, panic disorder, post-traumatic stress disorder, and social anxiety disorder. No previous analysis has directly com...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jad.2017.04.068
更新日期：2017-08-15 00:00:00
abstract：BACKGROUND:Suicidal ideation (SI) is a common and serious clinical concern in people with major depressive disorder (MDD). Inconsistent evidence suggests that individuals with SI may have a lower measured intelligence quotient (IQ) than those without SI. The aims of this study were to examine SI prevalence and its asso...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.12.017
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Depression remains the second leading cause of disability worldwide. Symptoms of depression are expressed and experienced differently across cultural groups, impacting treatment decisions. Patient preferences predict service utilization, treatment selection and persistence, as well as health outcomes for med...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.05.075
更新日期：2018-10-15 00:00:00
abstract：BACKGROUND:The transition from adolescence to adulthood is associated with stressful adaptation experiences that may increase symptoms of depression. We explored the prevalence and sex differences of depressive symptoms and suicidal ideation in freshmen Latino college students in Puerto Rico, and identified stressful l...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2012.08.010
更新日期：2013-03-05 00:00:00
abstract：BACKGROUND:Little is known about the early phases of bipolar disorders (BPAD) and most of current knowledge derives from putative "high-risk" studies conducted in populations of bipolar off-spring; such information may therefore be relevant only to a sub-group of at-risk subjects. METHODS:Retrospective assessment of t...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2009.12.021
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:The aim of this study was to characterize at the population level how innate features of temperament relate to experience of depressive mood and anxiety, and whether these symptoms have separable temperamental backgrounds. METHODS:The study subjects were 4773 members of the population-based Northern Finland...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2010.12.008
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:Histories of childhood trauma (CT) are risk factors for affect dysregulation and poor clinical outcomes in women with bipolar disorder (BD). While much is known about the link between BD and CT in adult patients, there is limited data on this research topic in pediatric BD (PBD). The present study aims to inv...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.12.007
更新日期：2019-03-15 00:00:00
abstract：INTRODUCTION:Empirical evidence has suggested an association between mood and color sensitivity. The purpose of this study is to report on the psychometric properties of a new postpartum depression rating scale while at the same time showing a correlation between depression severity and impaired color sensitivity. MET...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2012.03.039
更新日期：2012-12-10 00:00:00
abstract：BACKGROUND:More than 50% of individuals with bipolar disorder (BD) do not reach full psychosocial functioning, even during periods of euthymia. It has been suggested that history of psychotic symptoms is one of the factors which are associated with a worse functional outcome. The objective was to compare psychosocial f...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2017.12.094
更新日期：2018-03-15 00:00:00
abstract：BACKGROUND:Postnatal depression can have a major impact on the lives of women affected and on those around them. While effective treatments are available, it would be preferable to prevent the condition. The aim of this review was to examine the effectiveness of antenatal interventions designed to prevent postnatal dep...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2011.02.029
更新日期：2012-03-01 00:00:00
abstract：:We evaluated the efficacy of buspirone, in the augmentation of social phobic symptom response to the selective serotonin reuptake inhibitors (SSRIs). Ten patients meeting DSM-III-R criteria for generalized social phobia were studied. Patients obtaining only a partial response to an adequate trial of an SSRI, received ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(96)00030-4
更新日期：1996-07-08 00:00:00
abstract：BACKGROUND:While there has been research into the relationship between blood lead (BPb) level and mental disorders, there have been few investigations that use clinically diagnosed mental disorders in the adult population with a retrospective cohort study design. Hence, our study investigated the association between BP...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.09.030
更新日期：2016-01-15 00:00:00
