Is vecuronium toxicity abolished by hemodialysis? A case report.

Abstract:

:Vecuronium is a curaric agent, largely used in anesthesia. Indications as to its employ in uremic patients appear to be debated because of partial renal elimination of the drug. A 52-year-old hemodialyzed woman required transplantectomy for rejection. At awakeness after general anesthesia (induced with fentanyl, propofol, and 6 mg of vecuronium, repeated with a single 2 mg dose 30 min later), she presented diafragmatic and muscular limb weakeness that lasted 180 min in spite of prostigmine administration. A 2 h 30 min predilutional hemofiltration was then performed, which induced rapid disappearance of neuromuscular blockade. Even if vecuronium can be used in dialysis patients, one should remember its possible side effects, especially with repeated doses, in determining prolonged neuromuscular blockade. Cautious use of this drug in renal failure is mandatory. Low dosage must be employed and repeated administration avoided. Neuromuscular blockade seems to be rapidly reversible with dialytic treatment.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Rollino C,Visetti E,Borsa S,Pignataro A,Pozzato M,Vallero A,Quarello F

doi

10.1046/j.1525-1594.2000.06496.x

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

386-7

issue

5

eissn

0160-564X

issn

1525-1594

pii

aor6496

journal_volume

24

pub_type

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