In vitro toxicity assessment of mouthwashes in the pollen tube growth test: first results.

abstract：:Within the brain, dissemination of glioma cells follows myelinated fiber tracts and extracellular matrix containing structures such as the basement membranes of blood vessels. These patterns represent the two major routes of invasion frequently observed in clinical disease. Previously, we have characterized the substr...

journal_title：Anticancer research

authors： Giese A,Laube B,Zapf S,Mangold U,Westphal M

更新日期：1998-07-01 00:00:00

abstract：AIM:The aim of the present study was to evaluate the correlation between WT1 expression levels and clinical features, to investigate the prognostic value of WT1 expression and to use lentiviral constructs to examine whether overexpression of WT1 affects cell proliferation and invasion in ovarian cancer patients. MATER...

journal_title：Anticancer research

authors： Liu Z,Yamanouchi K,Ohtao T,Matsumura S,Seino M,Shridhar V,Takahashi T,Takahashi K,Kurachi H

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND/AIM:Human lectins translate sugar-encoded signals of cell surface glycoconjugates into biological effects, and this is what is known for the adhesion/growth-regulatory galectins. In addition, the multifunctional members of this group can be intracellular, binding to distinct proteins. The presence of galecti...

journal_title：Anticancer research

authors： Dawson H,André S,Karamitopoulou E,Zlobec I,Gabius HJ

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Hyperbaric oxygen (HBO) seems to intensify the effect of ionising radiation. We investigated whether HBO combined with irradiation decreases the capability of U251 glioblastoma cells for relapse and metastasis. MATERIALS AND METHODS:Cells were treated with O2 at 1.3 bar and then irradiated with 2 Gy photons...

journal_title：Anticancer research

authors： Bühler H,Strohm GL,Nguemgo-Kouam P,Lamm H,Fakhrian K,Adamietz IA

更新日期：2015-04-01 00:00:00

abstract：AIM:This study assessed the symptoms and health-related quality of life (HRQOL) of patients with advanced non-small cell lung cancer (NSCLC) and examined the symptom-associated characteristics. PATIENTS AND METHODS:The symptoms of 122 patients with NSCLC scheduled for chemotherapy before starting treatment were survey...

journal_title：Anticancer research

authors： Silvoniemi M,Vasankari T,Löyttyniemi E,Valtonen M,Salminen E

更新日期：2016-08-01 00:00:00

abstract：:This randomized study was designed to compare the efficacy and toxicity of MMV chemotherapy (mitomycin C(MMC), methotrexate (MTX) and vincristine(VCR)), MMVM (MMV+medroxyprogesterone acetate(MPA)) and MMVP (MMV+prednisolone(P)), and to evaluate potential additional effects of MPA or P to the chemotherapy in doxorubici...

journal_title：Anticancer research

authors： Tashiro H,Nomura Y

更新日期：1995-09-01 00:00:00

abstract：:Sarcomas in the forearm and hand are very rare, accounting for less than 1% of all upper-limb tumors and clinical outcomes after surgery and adjuvant therapies are uncertain. The forearm and hand present specific challenges due to their unique anatomical structures. There is little soft tissue and each compartment is ...

journal_title：Anticancer research

authors： Muramatsu K,Ihara K,Yoshida K,Tominaga Y,Hashimoto T,Taguchi T

更新日期：2013-10-01 00:00:00

abstract：:We have examined several aspects of protein tyrosine kinase (PTK)-activity in the cytosolic and membrane fractions of both normal and malignant lymphoid cells. The expression of the PTK-encoding oncogenes fes, abl and src, was investigated with the use of antibodies generated to their respective gene products. These a...

journal_title：Anticancer research

authors： Punt CJ,Rijksen G,van Oirschot BA,Kester-Schipper GP,van der Heijden MC,Dekker AW,Staal GE

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Abnormal hypermethylation of the CDKN2A (p14ARF and p16INK4a) gene can lead to repression of gene expression and contribute to carcinogenesis and tumor progression. MATERIALS AND METHODS:In esophageal squamous cell carcinoma (ESCC), the promoter methylation of the p14ARF and p16INK4a gene was investigated i...

journal_title：Anticancer research

authors： Ito S,Ohga T,Saeki H,Watanabe M,Kakeji Y,Morita M,Yamada T,Maehara Y

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND/AIM:The significance of microvascular invasion (MVI) of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) is unknown. PATIENTS AND METHODS:We studied 149 patients with solitary small-sized HCC (≤3 cm) who underwent hepatectomy, and developed a predictive model of MVI using independent facto...

journal_title：Anticancer research

authors： Imai K,Yamashita YI,Yusa T,Nakao Y,Itoyama R,Nakagawa S,Okabe H,Chikamoto A,Ishiko T,Baba H

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Paclitaxel pharmacokinetics were shown to be related to toxicity and survival. PATIENTS AND METHODS:We evaluated the effects of time above paclitaxel concentrations of 0.05 micromol/l (T(>0.05) and systemic exposures (AUC) to total and unbound paclitaxel (tPAC, uPAC) on response in patients with advanced ca...

journal_title：Anticancer research

authors： Mielke S,Sparreboom A,Behringer D,Mross K

更新日期：2005-11-01 00:00:00

abstract：:Melanoma is a tumor of continuously increasing incidence for which new methods of imaging and targeted therapy are widely sought. Radioiodinated methylene blue is a promising tracer, showing selective uptake in human pigmented melanoma cells. We performed 131I-labeling of the tracer using 1% methylene blue injection U...

journal_title：Anticancer research

authors： Sobal G,Rodrigues M,Sinzinger H

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Mistletoe lectins (ML), the major biologically active components of mistletoe extracts, which are used for adjuvant cancer therapy, induce apoptosis in lymphocytes and tumor cells. In addition, ML at toxic concentrations induce the release of cytokines, but it remains unclear as to whether dying or activated...

journal_title：Anticancer research

authors： Stein GM,Pfüller U,Schietzel M,Büssing A

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) is the prototypical biomarker of inflammation. Genetic variations within the CRP gene have been shown to be associated with alterations of CRP expression and prognosis in cancer patients. The purpose of this study was to evaluate the association between four polymorphisms of the CRP ...

journal_title：Anticancer research

authors： Polterauer S,Grimm C,Zeillinger R,Heinze G,Tempfer C,Reinthaller A,Hefler L

更新日期：2011-06-01 00:00:00

abstract：AIM:We investigated the immunohistochemical expression of estrogen receptors alpha (ERalpha) and beta (ERbeta) in pituitary adenoma subtypes combined with clinicopathological factors. MATERIALS AND METHODS:Pituitary adenomas (n=75) were immunostained for ERalpha and ERbeta using the streptavidin-biotin-peroxidase comp...

journal_title：Anticancer research

authors： Manoranjan B,Salehi F,Scheithauer BW,Rotondo F,Kovacs K,Cusimano MD

更新日期：2010-07-01 00:00:00

abstract：:Two different techniques [reduction of a tetrazolium derivative (MTT) and 3HTdR uptake assays] were compared in order to evaluate the cytotoxic effects of different chemotherapeutic agents in vitro. The cytotoxicities of Melphalan, hexamethylmelamine and seven derivatives, and daunorubicin were measured on P388D1 mous...

journal_title：Anticancer research

authors： Arnould R,Dubois J,Abikhalil F,Libert A,Ghanem G,Atassi G,Hanocq M,Lejeune FJ

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:DeltaNp63 is an isoform of the p53 homolog p63, which lacks an amino-terminal transactivation domain. The aim of this study was to detect the deltaNp63 expression in the squamous carcinoma component of adenosquamous carcinoma and evaluate its usefulness as a specific squamous carcinoma marker. PATIENTS AND ...

journal_title：Anticancer research

authors： Uramoto H,Yamada S,Hanagiri T

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Laparoscopic pelvic lymph node staging is widely used in patients with cervical cancer prior to the initiation of primary chemoradiation therapy. Data on the morbidity of this procedure are sparse. PATIENTS AND METHODS:Between 1995 and 2007, 71 patients with locally advanced cervical cancer (FIGO stage IB2-...

journal_title：Anticancer research

authors： Polterauer S,Hefler LA,Petry M,Seebacher V,Tempfer C,Reinthaller A

更新日期：2008-05-01 00:00:00

abstract：:The effect of dehydroepiandrosterone (DHEA) (2 mg, twice daily p.o.) on the growth of the dimethylbenz (a) anthracene (DMBA)-induced mammary carcinoma was studied in intact and ovariectomized adult female rats. DHEA treatment stimulated the tumor growth in ovariectomized animals. Conversely, the tumors of intact rats ...

journal_title：Anticancer research

authors： Boccuzzi G,Aragno M,Brignardello E,Tamagno E,Conti G,Di Monaco M,Racca S,Danni O,Di Carlo F

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:The process of tumour invasion and subsequent metastasis represents the most lethal aspect of cancer and is responsible for the majority of deaths among cancer patients. Our objective was to identify invasion-specific genes in a series of isogenic breast cancer cell lines of differing invasive potential usin...

journal_title：Anticancer research

authors： Hughes L,O'Brien SL,Gallagher WM,Mcdonnell S

更新日期：2007-05-01 00:00:00

abstract：:The recombinant plasmid pBHIV-1 carrying the long terminal repeat (LTR) of the human immunodeficiency virus 1 (HIV-1), linked to the reported chloramphenicol acetyl transferase (CAT) gene, was introduced into human and rat fibroblasts. Stable transfectants were obtained which were resistant to genetecin and expressed ...

journal_title：Anticancer research

authors： Zoumpourlis V,Eliopoulos AG,Spandidos DA

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND/AIM:SLC9A9 plays an oncogenic role in esophageal squamous carcinoma and glioblastoma. Herein, we showed an oncogenic function of SLC9A9 in colorectal cancer (CRC). MATERIALS AND METHODS:We examined SLC9A9 expression in CRC specimens by immunohistochemistry. In CRC tissues, the relationship between SLC9A9 ex...

journal_title：Anticancer research

authors： Ueda M,Iguchi T,Masuda T,Komatsu H,Nambara S,Sakimura S,Hirata H,Uchi R,Eguchi H,Ito S,Sugimachi K,Mizushima T,Doki Y,Mori M,Mimori K

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The antiemetic effects of serotonin receptor antagonists during chemoradiotherapy for solid tumors have never been reported. We have developed hyperthermo-chemo-radiotherapy (HCR) for esophageal cancer. However, with this treatment, the more potent the chemotherapy was, the more frequently emesis was experie...

journal_title：Anticancer research

authors： Morita M,Kuwano H,Ohno S,Kitamura K,Sugimachi K

更新日期：2000-09-01 00:00:00

abstract：:Two monoclonal antibodies, KM227 (IgM) and KM432 (IgG1), were established by immunizing mice with the crude membrane fraction of lung squamous cell carcinoma and the high-molecular-weight antigen in pleural perfusion from patients with lung adenocarcinoma, respectively. They were found to recognize the carbohydrate ep...

journal_title：Anticancer research

authors： Shitara K,Hanai N,Yoshida H

更新日期：1993-05-01 00:00:00

abstract：:This study is related to the serious side effects of Doxorubicin-cardiotoxicity and serum lipid caused by the drug's cumulative effect. Studies were performed on experimental animals treated with intensive administration of Doxorubicin. Seventy five wistar rats were divided in two equal groups A and B. Group A was use...

journal_title：Anticancer research

authors： Samelis GF,Stathopoulos GP,Kotsarelis D,Dontas I,Frangia C,Karayannacos PE

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND/AIM:KRAS and BRAF are two genes commonly mutated in colorectal cancer (CRC). Even though BRAF is a downstream target of KRAS in the MAPK signalling pathway, KRAS- and BRAF-mutated CRCs are found to display several different clinical and histopathological features. We investigated whether a differential expre...

journal_title：Anticancer research

authors： Lundberg IV,Wikberg ML,Ljuslinder I,Li X,Myte R,Zingmark C,Löfgren-Burström A,Edin S,Palmqvist R

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs), which are endogenously expressed regulatory noncoding RNAs, have an altered expression in tumor tissues. MiRNAs regulate cancer-related processes such as cell growth and tissue differentiation, and therefore, might function as oncogenes or tumor-suppressor genes. The aim of our study was ...

journal_title：Anticancer research

authors： Pesta M,Klecka J,Kulda V,Topolcan O,Hora M,Eret V,Ludvikova M,Babjuk M,Novak K,Stolz J,Holubec L

更新日期：2010-09-01 00:00:00

abstract：:The E6 protein of the high-risk human papillomavirus (HPV) types 16 and 18 is capable of complexing with the wild-type p53 tumor suppressor gene product, leading to loss of the normal p53 function as an anti-oncogene, whereas the low-risk HPV types 6 and 11 lack this binding property. The malignant potential of HPV 16...

journal_title：Anticancer research

authors： Tervahauta AI,Syrjänen SM,Väyrynen M,Saastamoinen J,Syrjänen KJ

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND/AIM:The objective of this study was to determine the molecular and clinicopathological features, as well as the prognosis of patients with endometrial cancer (EC) having prior malignancy (second primary EC: SPEC) compared with those without a history of prior malignancy (first primary EC: FPEC). MATERIALS A...

journal_title：Anticancer research

authors： Haraga J,Nakamura K,Haruma T,Nyuya A,Nagasaka T,Masuyama H

更新日期：2020-07-01 00:00:00

abstract：:We have examined the effects of irradiation on the cytokine secretion from genetically modified human esophageal and gastric carcinomas. Both cell lines were transduced retrovirally to secrete interleukin-2, interleukin-6 and granulocyte-macrophage colony-stimulating factor, respectively. The metabolism of all the tra...

journal_title：Anticancer research

authors： Matsubara H,Tagawa M,Gunji Y,Takenaga K,Sugaya M,Urashima T,Koide Y,Suzuki T,Asano T,Ochiai T,Isono K,Kageyama H,Nakamura Y,Sakiyama S

更新日期：1996-03-01 00:00:00