Abstract:
:Our recent studies have shown that vanadium, a dietary micronutrient, has an inhibitory response against experimentally induced rat liver carcinogenesis. In the present study, the effect of vanadium on hepatic xenobiotic biotransformation in rats exposed to diethylnitrosamine (DENA, 200 mg/kg, IP) was investigated to elucidate a possible mechanism of vanadium-mediated prevention of chemical carcinogenesis. Supplementary vanadium in drinking water at 0.5 parts per million (ppm) was employed ad lib before and after the intiation with DENA, before the initiation only, or during the promotional event. After 20 weeks, there was a significant reduction of hepatocyte nodules (HNs) (P<0.01), nodule multiplicity (P<0.001), and the number of nodules more than 3 mm in size in the long-term vanadium-supplemented rats than their DENA control counterparts. Total cytochrome P450 and b5 contents as well as cytochrome P450 2E1 (CYP2E1, EC 1.5.99), aryl hydrocarbon hydroxylase (AHH, EC 1.14.14.2), and UDP-glucuronyl transferase (UDPGT, EC 2.4.1.17) activities in the microsomal fractions of HNs and nonnodular surrounding parenchyma (NNSP) were found to be significantly decreased in DENA control group compared to untreated normal control. Though supplementary vanadium had little or no influence on the contents of cytochrome P450 and b5 and activities of CYP2E1 and AHH in HNs and NNSP, it substantially elevated the UDPGT activity in both HNs and NNSP liver areas. DENA treatment alone also brought about a sharp decrease in cytosolic UDP-glucose dehydrogenase (EC 1.1.1.22), DT-diaphorase (EC 1.6.99.2), and glutathione S-transferase (EC 2.5.1.18) activities in HNs and NNSP compared to normal liver. Supplementary vanadium was found to exert a marked induction in these cytosolic enzymes in HNs as well as NNSP when compared to DENA control. A positive correlation of phase I and phase II drug metabolizing enzymes in HNs or NNSP was always observed in DENA or DENA plus long-term vanadium-treated group. It is concluded that the chemoprotective effect of vanadium may be attributed to the substantial elevation of phase II conjugating enzymes, which may lead to a move and shift of the metabolic profile that may reduce the intracellular concentration of carcinogen-derived reactive intermediates.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Bishayee A,Roy S,Chatterjee Msubject
Has Abstractpub_date
1999-01-01 00:00:00pages
41-53issue
1eissn
0965-0407issn
1555-3906journal_volume
11pub_type
杂志文章abstract::We investigated the regulatory effect of interleukin (IL) 10 on IL-12-inducible killer activity of blood mononuclear cells (MNC) of healthy subjects. IL-10 suppressed non-MHC-restricted killer activity induced by IL-12 in a dose-dependent manner. Cytotoxicity against Daudi cells of blood MNC activated with optimal dos...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::ErbB4 is a member of the ErbB family of receptor tyrosine kinases. Because of a paucity of appropriate pharmacologic tools, little is known about ErbB4 functions in vivo. In response to this need, we hypothesized that a recombinant form of the extracellular domain of ErbB4 would antagonize ligand-induced receptor tyro...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/0965040042707907
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abstract::The mechanism of action of the anthraquinone antileukemic drug mitoxantrone (MIT) was investigated and compared with that of daunorubicin (DNR) with emphasis on the interaction with DNA to clarify the more potent cytotoxic activity of MIT than DNR in human leukemia cells. MIT showed similar characteristics to those of...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::The aim of this study was to analyze the efficacy according to EGFR status and predictors of TKIs in Chinese advanced lung adenocarcinoma patients in a single institute. We retrospectively enrolled 253 patients with advanced or recurrent adenocarcinoma and history of EGFR-TKI treatment attended at Beijing Chest Hospit...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504014X13907540404833
更新日期:2014-01-01 00:00:00
abstract::Ovarian cancer is highly malignant with a gradually increasing incidence and a high mortality rate. Immunosuppression is induced in ovarian cancer, although the mechanism detail is not clear. It has been indicated that HVEM (herpesvirus entry mediator) B- and T-lymphocyte attenuator (BTLA) negatively regulates the imm...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504016X14641336229602
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abstract::HL-60 cells isolated for resistance to vincristine are multidrug resistant and defective in the cellular accumulation of drug. Further studies demonstrate that these cells are also highly defective in 12-O-tetradecanoylphorbol-13-acetate (TPA) induced differentiation to macrophages. Analysis of this system demonstrate...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Phytochemicals present in tea, particularly polyphenols, have anticancer properties against several cancer types. However, studies elucidating the role and the mechanism(s) of action of tea polyphenols in cervical cancer are sparse. In this study, we investigated the mechanism of antiproliferative and apoptotic action...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504011x13021877989711
更新日期:2011-01-01 00:00:00
abstract::HeLa cells were transfected with full-length multidrug resistance protein (MRP) cDNA and with MRP cDNAs that had been mutated at certain nucleotide binding domains. Stable transfectants were isolated and those producing equivalent amounts of P190 were tested in cytotoxicity assays using a variety of chemotherapeutic a...
journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504016X14761384026719
更新日期:2017-05-24 00:00:00
abstract::MicroRNAs (miRNAs) play important roles in the carcinogenesis of cervical cancer. However, the expression and underlying mechanisms of miRNA in cervical cancer progression remain unclear. In the present study, our data showed that the expression of miR-138-5p was significantly downregulated in cervical cancer tissues,...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X15017209042610
更新日期:2018-04-10 00:00:00
abstract::The potency of flavonoids (isoflavones, flavones, and flavanones) to inhibit efflux of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein (BCPCF) from human erythrocytes was investigated. Structure-activity relationship analysis showed that the strongest inhibitors were found among flavanones bearing a hydrophobic pren...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/000000003108747983
更新日期:2003-01-01 00:00:00
abstract::The ability of mitoxantrone to form DNA adducts was investigated in a series of human tumor cell lines consisting of human cervical cancer (HeLa), human breast cancer (MCF-7), and human neuroblastoma (IMR-32) cells. The mitoxantrone-resistant human promyelocytic leukemia cell line HL60/MX2 was also compared to the par...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504003773994815
更新日期:2004-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/000000007783630006
更新日期:2007-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/000000003108748612
更新日期:2003-01-01 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504016X14761811155298
更新日期:2017-04-14 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504013X13685487925095
更新日期:2013-01-01 00:00:00
abstract::Cancer-associated fibroblasts (CAFs) play a predominant role in regulating tumor progression. Understanding how CAFs communicate with osteosarcoma is crucial for developing novel approaches for osteosarcoma therapy. Exosomes are able to transmit messages between cells. In this study, we demonstrated that CAFs transfer...
journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504018X15336368805108
更新日期:2019-09-23 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:10.3727/096504017X14957939026111
更新日期:2018-04-27 00:00:00
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journal_title:Oncology research
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更新日期:2011-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Oncology research
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Oncology research
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journal_title:Oncology research
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doi:10.3727/096504008786991611
更新日期:2008-01-01 00:00:00
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journal_title:Oncology research
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doi:10.3727/0965040041292350
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journal_title:Oncology research
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doi:10.3727/096504017X14965111926391
更新日期:2018-03-05 00:00:00
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journal_title:Oncology research
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doi:10.3727/096504017X14841698396829
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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