HL-60 cells isolated for resistance to vincristine are defective in 12-O-tetradecanoylphorbol-13-acetate induced differentiation and the formation of a functional AP-1 complex.

abstract：:Gastric cancer (GC) is the most common epithelial malignancy worldwide. Basic transcription factor 3 (BTF3) plays a crucial role in the regulation of various biological processes. We designed experiments to investigate the molecular mechanism underlying the role of BTF3 in GC cell proliferation and metastasis. We conf...

journal_title：Oncology research

authors： Zhang DZ,Chen BH,Zhang LF,Cheng MK,Fang XJ,Wu XJ

更新日期：2017-11-02 00:00:00

abstract：:The present study evaluated the modulatory effects of zinc on colonic membrane fluidity and surface abnormalities following 1,2 dimethylhydrazine (DMH)-induced colon carcinogenesis. Rats were segregated into four groups: normal control, DMH treated, zinc treated, DMH + zinc treated. Colon carcinogenesis was initiated ...

journal_title：Oncology research

authors： Chadha VD,Dhawan DK

更新日期：2009-01-01 00:00:00

abstract：:Laryngeal cancer, one of the most common head and neck malignancies, is an aggressive neoplasm. Increasing evidence has demonstrated that microRNAs (miRNAs) exert important roles in oncogenesis and progression of diverse types of human cancers. miR-632, a tumor-related miRNA, has been reported to be dysregulated and i...

journal_title：Oncology research

authors： Zhou ZX,Zhang ZP,Tao ZZ,Tan TZ

更新日期：2020-02-07 00:00:00

abstract：:DT-diaphorase [also called NAD(P)H:menadione oxidoreductase; NAD(P)H:(quinone acceptor) oxidoreductase; quinone reductase, azo-dye reductase] (EC.1.6.99.2) has been shown to have a role in activation of quinone-containing cancer chemotherapeutic prodrugs to their active form, as well as inactivation of a variety of xe...

journal_title：Oncology research

authors： Rauth AM,Goldberg Z,Misra V

更新日期：1997-01-01 00:00:00

abstract：:This commentary proposes the working hypothesis that transforming growth factor-beta (TGF-beta) can play two different and opposite roles with respect to the process of malignant progression. During the earliest stages of carcinogenesis, TGF-beta can act as potent tumor suppressor and may mediate the actions of chemop...

journal_title：Oncology research

authors： Reiss M

更新日期：1997-01-01 00:00:00

abstract：:Pyroptosis is a type of proinflammatory programmed cell death mediated by caspase 1 activity and occurs in several types of eukaryotic tumor cells, including gliomas. MicroRNAs (miRNAs), small endogenous noncoding RNAs, have been demonstrated to be advantageous in glioma therapy. However, the question of whether miRNA...

journal_title：Oncology research

authors： Jiang Z,Yao L,Ma H,Xu P,Li Z,Guo M,Chen J,Bao H,Qiao S,Zhao Y,Shen J,Zhu M,Meyers C,Ma G,Xie C,Liu L,Wang H,Zhang W,Dong Q,Shen H,Lin Z

更新日期：2017-07-05 00:00:00

abstract：:Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the initiation and development of many solid tumors, including osteosarcoma (OS). In this study, we showed that MALAT1 was increased in human OS tissues and cell lines. MALAT1 knockdown suppressed OS ce...

journal_title：Oncology research

authors： Zhang Y,Dai Q,Zeng F,Liu H

更新日期：2018-04-27 00:00:00

abstract：:The poly(ADP-ribose) polymerase (PARP) enzymes play a key role in the regulation of cellular processes (e.g., DNA damage repair, genomic stability). It has been shown that PARP inhibitors (PARPIs) are selectively cytotoxic against cells having dysfunctions in genes involved in DNA repair mechanisms (synthetic lethalit...

journal_title：Oncology research

authors： Mini E,Landini I,Lucarini L,Lapucci A,Napoli C,Perrone G,Tassi R,Masini E,Moroni F,Nobili S

更新日期：2017-11-02 00:00:00

abstract：:The anticancer drug Adriamycin is widely used in cancer chemotherapy and is classified as a topoisomerase II inhibitor. However, in the presence of formaldehyde, Adriamycin also forms high levels of DNA adducts. In this study, a new series of butyric acid and formaldehyde-releasing drugs related to AN9 (pivaloyloxymet...

journal_title：Oncology research

authors： Cutts SM,Nudelman A,Pillay V,Spencer DM,Levovich I,Rephaeli A,Phillips DR

更新日期：2005-01-01 00:00:00

abstract：:Agosterol A (AG-A) is a novel agent that reverses P-glycoprotein (P-gp) and multidrug resistance protein-1 (MRP1)-meditated multidrug resistance (MDR). We have synthesized [125I]11-azidophenyl agosterol A (azidoAG-A), a photoaffinity analog of AG-A, and characterized its binding to P-gp in membrane vesicles prepared f...

journal_title：Oncology research

authors： Mitsuo M,Noguchi T,Nakajima Y,Aoki S,Ren XQ,Sumizawa T,Haraguchi M,Kobayashi M,Baba M,Nagata Y,Akiyama S,Furukawa T

更新日期：2003-01-01 00:00:00

abstract：:Glioma is a common type of malignant brain tumor characterized by aggressive metastasis capability. Recent evidence has suggested that noncoding RNAs, including microRNAs, have important functions in the pathophysiology of glioma development. In this study, we investigated the biological function of miR-422a in human ...

journal_title：Oncology research

authors： Wang H,Tang C,Na M,Ma W,Jiang Z,Gu Y,Ma G,Ge H,Shen H,Lin Z

更新日期：2017-01-26 00:00:00

abstract：:Expression of sphingosine kinase 1 (SPHK1) plays a role in colorectal cancer progression. This study aimed to demonstrate the mechanism of human colorectal cancer cell metastatic phenotype through SPHK1 knockdown. Human colorectal cancer HT-29 cells were stimulated by phorbol 12-myristate 13-acetate (PMA) with or with...

journal_title：Oncology research

authors： Qin MB,Huang JA,Liu SQ,Tang GD,Jiang HX

更新日期：2011-01-01 00:00:00

abstract：:Spinal osteosarcoma (OS) is a malignant tumor that has a poor outcome. MicroRNA-520b (miR-520b) acts as a cancer suppressor in various types of cancer. Because of the limited amount of literature on OS, we aimed to identify the role of miR-520b in OS. The miR-520b level in clinical spinal OS tissues and adjacent nontu...

journal_title：Oncology research

authors： Wang J,Pang W,Zuo Z,Zhang W,He W

更新日期：2017-09-21 00:00:00

abstract：:N-Butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), which induces bladder carcinoma in female Wistar rats and female C3H/HeJ mice, was given as 0.025% (w/v) solution to rats and 0.05% to mice in the drinking water. Thymosin fraction 5 (TF5) or thymosin alpha 1 (T alpha 1) dissolved in normal saline, and normal saline (contr...

journal_title：Oncology research

authors： Wada S,Kinoshita Y,Kamizuru M,Asai Y,Iwata H,Ikemoto S,Hato F,Kishimoto T,Fukushima S

更新日期：1996-01-01 00:00:00

abstract：:To elucidate the proteins related to the development and progress of esophageal squamous cell carcinoma (ESCC), we performed gene expression profile analysis of 14 ESCC tissues. We identified 182 genes that were commonly upregulated (p < 10(-5)) and 54 genes that were downregulated in ESCC tissues (p < 10(-6)). In ord...

journal_title：Oncology research

authors： Kwon YJ,Lee SJ,Koh JS,Kim SH,Kim YJ,Park JH

更新日期：2009-01-01 00:00:00

abstract：:S100 binding protein A16 (S100A16) expression levels are closely associated with microRNA (miRNA) processing. Higher levels of S100A16 are reported during the progression of many cancers. Our study mainly explored the interaction between S100A16 and miR-6884-5p in gastric cancer (GC). Quantitative real-time polymerase...

journal_title：Oncology research

authors： Lv H,Hou H,Lei H,Nie C,Chen B,Bie L,Han L,Chen X

更新日期：2020-05-29 00:00:00

abstract：:The present study aimed to investigate the effect of miR-186 on proliferation, migration, invasion, and epithelialmesenchymal transition (EMT) of hepatocellular carcinoma (HCC). In this work, miR-186 was downregulated in HCC tissues and cells, and low miR-186 level helped predict the occurrence of vascular invasion an...

journal_title：Oncology research

authors： Lu J,Zhao Z,Ma Y

更新日期：2020-12-10 00:00:00

abstract：:To enhance the anticancer efficacy of gemcitabine in the treatment of non-small cell lung cancer (NSCLC), the potential synergistic effect of piceatannol on gemcitabine cytotoxicity was investigated in the human NSCLC A459 cell line. The MTT cell viability assay showed that piceatannol significantly enhanced the cytot...

journal_title：Oncology research

authors： Xu B,Tao ZZ

更新日期：2014-01-01 00:00:00

abstract：:We have compared the effects of a number of inhibitors including aphidicolin, 2,4-dinitrophenol (DNP) and novobiocin on the in vitro cytotoxicity of several topoisomerase II (topo II)-directed agents, using cultured murine Lewis lung carcinoma cells. These agents comprised amsacrine, CI-921 (9-[(2-methoxy-4-methylsulf...

journal_title：Oncology research

authors： Haldane A,Finlay GJ,Baguley BC

更新日期：1993-01-01 00:00:00

abstract：:Signal peptide CUB EGF-like domain-containing protein 2 (SCUBE2), a member of the SCUBE family of proteins, was recently found to play an important role in cancer development. However, little is known regarding its biological function in glioma. In the present study, we investigated the effect of SCUBE2 on glioma and ...

journal_title：Oncology research

authors： Guo E,Liu H,Liu X

更新日期：2017-03-13 00:00:00

abstract：:A novel keto-diepoxide Sch 49209 and its derivative Sch 50672, produced by the fungus Nattrassia mangiferae, inhibited tumor cell invasion through an artificial basement membrane. These compounds, at nontoxic concentrations, inhibited invasion of HT-1080 cells in a dose-dependent manner. The IC50 values for Sch 49209 ...

journal_title：Oncology research

authors： King I,Blood C,Chu M,Patel M,Liu M,Li Z,Robertson N,Maxwell E,Catino JJ

更新日期：1995-01-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) has remained an enigmatic disease, the etiology of which is mostly unknown. Considering the age incidence around menopause, a "gonadotrophin theory" has been proposed, and considering the association with infertility, an "incessant ovulation" theory has been proposed. EOC originates fro...

journal_title：Oncology research

authors： Bose CK

更新日期：2008-01-01 00:00:00

abstract：:The importance of receptors involved in the clearance of proteases and protease/inhibitor complexes in tumor invasion is unknown. We studied the expression of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP/alpha 2-MR), the major receptor involved in the clearance of protease/i...

journal_title：Oncology research

authors： Kancha RK,Stearns ME,Hussain MM

更新日期：1994-01-01 00:00:00

abstract：:All-trans-Retinoic acid (RA) induces differentiation and inhibits growth of many tumor types. Whereas the RA nuclear receptors mediate genomic effects of RA, there also are many nongenomic effects that do not have defined mechanisms. Some nongenomic effects of RA may involve retinoylation (RA acylation), a posttransla...

journal_title：Oncology research

authors： Takahashi N,Iwahori A,Breitman TR,Fukui T

更新日期：1997-01-01 00:00:00

abstract：:The aim of this study was to analyze the efficacy according to EGFR status and predictors of TKIs in Chinese advanced lung adenocarcinoma patients in a single institute. We retrospectively enrolled 253 patients with advanced or recurrent adenocarcinoma and history of EGFR-TKI treatment attended at Beijing Chest Hospit...

journal_title：Oncology research

authors： Wang J,Nong J,Jia H,Qin N,Li X,Zhang H,Zhang Q,Zhang Z,Zhang S

更新日期：2014-01-01 00:00:00

abstract：:We previously reported that vasoactive intestinal polypeptide (VIP) significantly inhibited Matrigel invasion and haptotactic migration of murine colon 26-L5 carcinoma in vitro. To extend our study, we investigated the inhibitory mechanisms of VIP on Matrigel invasion of colon 26-L5 carcinoma, and the effect on metast...

journal_title：Oncology research

authors： Ogasawara M,Murata J,Ayukawa K,Saiki I

更新日期：1998-01-01 00:00:00

abstract：:Baicalein, a flavonoid derived from the root of Scutellaria baicalensis, has been reported to possess multiple pharmacological activities, such as anticancer and anti-inflammatory properties. This study investigated the effect of baicalein in cervical cancer cells. Cell growth curve and MTT assay were performed and re...

journal_title：Oncology research

authors： Wu X,Yang Z,Dang H,Peng H,Dai Z

更新日期：2018-05-07 00:00:00

abstract：:MTA1 was reported as a metastasis-associated gene. Tumors with higher MTA1 mRNA level were shown to have higher rates of invasion and lymph node metastasis and tended to have higher rates of vascular involvement. The majority of invasive breast carcinomas were demonstrated to overexpress MTA1 compared to surrounding n...

journal_title：Oncology research

authors： Tong D,Heinze G,Schremmer M,Schuster E,Czerwenka K,Leodolter S,Zeillinger R

更新日期：2007-01-01 00:00:00

abstract：:Tripartite motif-containing protein 37 (TRIM37), a new member of the RING-B-box-coiled-coil (RBCC) subfamily of zinc finger proteins, was found to be involved in the development and progression of several cancers. However, the expression pattern and biological functions of TRIM37 in colorectal cancer (CRC) remain unkn...

journal_title：Oncology research

authors： Zhao P,Guan HT,Dai ZJ,Ma YG,Liu XX,Wang XJ

更新日期：2017-01-02 00:00:00

abstract：:We applied a differential display method to screen mRNAs isolated from a newly established cell line that carried a wild-type p53 transgene under control of the lactose operon. To investigate the p53 signaling pathway, we looked for genes whose expression was significantly induced or suppressed by induction of wild-ty...

journal_title：Oncology research

authors： Okamura S,Ng CC,Koyama K,Takei Y,Arakawa H,Monden M,Nakamura Y

更新日期：1999-01-01 00:00:00