Formaldehyde-releasing prodrugs in combination with adriamycin can overcome cellular drug resistance.

abstract：:Currently, multiple microRNAs (miRNAs) have been found to play vital roles in the pathogenesis of osteosarcoma. This study aimed to investigate the role of miR-21 in osteosarcoma. The level of miR-21 in 20 pairs of osteosarcoma and corresponding adjacent tissues was monitored by qPCR. Human osteosarcoma cell line SAOS...

journal_title：Oncology research

authors： Xu B,Xia H,Cao J,Wang Z,Yang Y,Lin Y

更新日期：2017-08-07 00:00:00

abstract：:Triptorelin, a kind of GnRH agonist, is widely used in the treatment of hormone-responsive cancers in the clinic. This study aimed to discover the underlying mechanism of triptorelin in protection from 5-fluorouracil (5-FU)-induced ovarian damage in Sprague-Dawley rats. In the present study, after using 5-FU to induce...

journal_title：Oncology research

authors： Wang Y,Tian X,Liang L,Wang Y,Wang R,Cheng X,Yan Z,Chen Y,Qi P

更新日期：2014-01-01 00:00:00

abstract：:DT-diaphorase [also called NAD(P)H:menadione oxidoreductase; NAD(P)H:(quinone acceptor) oxidoreductase; quinone reductase, azo-dye reductase] (EC.1.6.99.2) has been shown to have a role in activation of quinone-containing cancer chemotherapeutic prodrugs to their active form, as well as inactivation of a variety of xe...

journal_title：Oncology research

authors： Rauth AM,Goldberg Z,Misra V

更新日期：1997-01-01 00:00:00

abstract：:A number of previous investigations have reported that physical exercise renders immunopotentiating and antitumor therapeutic benefits to the tumor-bearing host. As these effects of physical exercise are mainly mediated through the modulation of hormonal and cytokine repertoire, it remains unclear if male and female t...

journal_title：Oncology research

authors： Verma VK,Singh V,Singh MP,Singh SM

更新日期：2010-01-01 00:00:00

abstract：:The present study evaluated the modulatory effects of zinc on colonic membrane fluidity and surface abnormalities following 1,2 dimethylhydrazine (DMH)-induced colon carcinogenesis. Rats were segregated into four groups: normal control, DMH treated, zinc treated, DMH + zinc treated. Colon carcinogenesis was initiated ...

journal_title：Oncology research

authors： Chadha VD,Dhawan DK

更新日期：2009-01-01 00:00:00

abstract：:The ability of mitoxantrone to form DNA adducts was investigated in a series of human tumor cell lines consisting of human cervical cancer (HeLa), human breast cancer (MCF-7), and human neuroblastoma (IMR-32) cells. The mitoxantrone-resistant human promyelocytic leukemia cell line HL60/MX2 was also compared to the par...

journal_title：Oncology research

authors： Parker BS,Rephaeli A,Nudelman A,Phillips DR,Cutts SM

更新日期：2004-01-01 00:00:00

abstract：:The purpose of this study was to investigate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) treatment in Chinese hepatocellular carcinoma (HCC) patients and the prognostic factors for treatment response as well as survival. A total of 275 HCC patients were included in this pro...

journal_title：Oncology research

authors： Sun J,Zhou G,Xie X,Gu W,Huang J,Zhu D,Hu W,Hou Q,Shi C,Li T,Zhang X,Ji W,Ying S,Peng Z,Zhou J,Yu Z,Ji J,Du H,Guo X,Fang J,Han J,Xu H,Sun Z,Yu W,Shao G,Wu X,Hu H,Li L,Zheng J,Luo J,Chen Y,Cao

更新日期：2020-02-07 00:00:00

abstract：:ErbB4 is a member of the ErbB family of receptor tyrosine kinases. Because of a paucity of appropriate pharmacologic tools, little is known about ErbB4 functions in vivo. In response to this need, we hypothesized that a recombinant form of the extracellular domain of ErbB4 would antagonize ligand-induced receptor tyro...

journal_title：Oncology research

authors： Gilmore JL,Riese DJ 2nd

更新日期：2004-01-01 00:00:00

abstract：:Our recent studies have shown that vanadium, a dietary micronutrient, has an inhibitory response against experimentally induced rat liver carcinogenesis. In the present study, the effect of vanadium on hepatic xenobiotic biotransformation in rats exposed to diethylnitrosamine (DENA, 200 mg/kg, IP) was investigated to ...

journal_title：Oncology research

authors： Bishayee A,Roy S,Chatterjee M

更新日期：1999-01-01 00:00:00

abstract：:All-trans-Retinoic acid (RA) induces differentiation and inhibits growth of many tumor types. Whereas the RA nuclear receptors mediate genomic effects of RA, there also are many nongenomic effects that do not have defined mechanisms. Some nongenomic effects of RA may involve retinoylation (RA acylation), a posttransla...

journal_title：Oncology research

authors： Takahashi N,Iwahori A,Breitman TR,Fukui T

更新日期：1997-01-01 00:00:00

abstract：:Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are used as first-line agents for treating nonsquamous cell lung cancer with EGFR mutation, there are many patients who have to receive these drugs following platinum-based chemotherapy. This study was designed to define whether exposure ...

journal_title：Oncology research

authors： Rho JK,Choi YJ,Choi YR,Kim SY,Choi SJ,Choi CM,Na II,Lee JC

更新日期：2011-01-01 00:00:00

abstract：:Accumulated studies have strongly implicated aberrantly expressed microRNAs (miRNAs) in carcinogenesis and cancer progression of various cancers, including colorectal cancer (CRC). Hence, a comprehensive study of miRNAs and their association with CRC may be a promising therapeutic method for patients with this maligna...

journal_title：Oncology research

authors： Shen J,Li M

更新日期：2018-10-17 00:00:00

abstract：:Gastric cancer (GC) is the most common epithelial malignancy worldwide. Basic transcription factor 3 (BTF3) plays a crucial role in the regulation of various biological processes. We designed experiments to investigate the molecular mechanism underlying the role of BTF3 in GC cell proliferation and metastasis. We conf...

journal_title：Oncology research

authors： Zhang DZ,Chen BH,Zhang LF,Cheng MK,Fang XJ,Wu XJ

更新日期：2017-11-02 00:00:00

abstract：:Colorectal cancer is an aggressive malignancy for which there are limited treatment options. Oncolytic vaccinia virus isbeing developed as a novel strategy for cancer therapy. Arming vaccinia virus with immunostimulatory cytokines can enhance the tumor cell-specific replication and antitumor efficacy. Interleukin-24 (...

journal_title：Oncology research

authors： Deng L,Yang X,Fan J,Ding Y,Peng Y,Xu D,Huang B,Hu Z

更新日期：2020-07-08 00:00:00

abstract：: THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHER IN NOVEMBER 2020. ...

journal_title：Oncology research

authors： Yongyu Z,Lewei Y,Jian L,Yuqin S

更新日期：2018-10-17 00:00:00

abstract：:The sequence of biochemical and molecular events that mediate growth arrest and cell death in tumor cells exposed to agents that induce DNA damage is poorly defined. This commentary exploits the recent explosion of information regarding oncogenes, tumor suppressor genes, and cell-cycle regulatory genes to develop a mo...

journal_title：Oncology research

authors： Gewirtz DA

更新日期：1993-01-01 00:00:00

abstract：:Accumulation of beta-catenin in cytoplasm and nuclei is frequently observed in a wide variety of tumors arising, for example, in the colon, liver, uterus, or brain. In association with Tcf/LEF transcription factors, beta-catenin regulates expression of genes involved in the Wnt/wingless signaling pathway, but the prec...

journal_title：Oncology research

authors： Miwa N,Furuse M,Tsukita S,Niikawa N,Nakamura Y,Furukawa Y

更新日期：2001-01-01 00:00:00

abstract：:Thymosin-beta-4 (TB4) as an actin-sequestering peptide has been detected outside of cells in blood plasma or in wound fluid. TB4 induces tumor metastasis and paclitaxel resistance, which is the most significant obstacle to successful therapy in tumors. Here we investigated the inhibitory effect of TB4 peptides on tumo...

journal_title：Oncology research

authors： Moon EY,Song JH,Yang KH

更新日期：2007-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies, with a poor prognosis and high recurrence rate. In the present study, we identified CD133, one of the markers of cancer stem cells, as a novel molecular target of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). In four human HCC ce...

journal_title：Oncology research

authors： Lee SH,Hyun SK,Kim HB,Kang CD,Kim SH

更新日期：2016-10-27 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated mortality worldwide. Although the mechanisms of HCC progression are not well understood, recent studies demonstrated the potential contribution of uric acid transporter SLC2A9 to tumor suppression. However, the roles and underlying mechanis...

journal_title：Oncology research

authors： Han X,Yang J,Li D,Guo Z

更新日期：2019-05-07 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) play a predominant role in regulating tumor progression. Understanding how CAFs communicate with osteosarcoma is crucial for developing novel approaches for osteosarcoma therapy. Exosomes are able to transmit messages between cells. In this study, we demonstrated that CAFs transfer...

journal_title：Oncology research

authors： Wang JW,Wu XF,Gu XJ,Jiang XH

更新日期：2019-09-23 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is an uncommon and highly aggressive tumor of the neuroendocrine system, which derives from the neuroendocrine C cells of the thyroid gland. Except for surgical resection, there are not very many effective systemic treatment options for MTC. N-Myc downstream-regulated gene 2 (NDRG2) h...

journal_title：Oncology research

authors： Yin A,Wang C,Sun J,Gao J,Tao L,Du X,Zhao H,Yang J,Li Y

更新日期：2016-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) are at the foundation of the hematopoietic hierarchy and give rise to all blood lineages in the adult organism. A thorough understanding of the molecular, cellular, and developmental biology of HSCs is of fundamental importance, but is also clinically relevant for the advancement of cel...

journal_title：Oncology research

authors： Robin C,Ottersbach K,de Bruijn M,Ma X,van der Horn K,Dzierzak E

更新日期：2003-01-01 00:00:00

abstract：:Drug resistance is the major obstacle for the successful therapy of lung adenocarcinoma. It was suggested that ß-elemene, a major isoform of elemene, could reverse the drug resistance in lung cancer cells. However, the underlying mechanisms remains poorly known. Here, we aimed to investigate whether elemene is involve...

journal_title：Oncology research

authors： Zhou K,Wang L,Cheng R,Liu X,Mao S,Yan Y

更新日期：2017-05-23 00:00:00

abstract：:In colorectal cancers, the local cytokine network and the levels of nitric oxide (NO) and reactive oxygen species (ROS) are known to be closely related to cancer progression and metastasis, but the influence of the currently administered therapies on the cancer microenvironment is not completely understood. We analyze...

journal_title：Oncology research

authors： Paduch R,Kandefer-Szerszeń M,Piersiak T

更新日期：2010-01-01 00:00:00

abstract：:Chemoresistance is a major impediment to the successful treatment of cancer. It involves various mechanisms, including defects in the apoptosis program that is induced by anticancer drugs. To further explore the mechanisms underlying the development of chemoresistance in ovarian carcinoma after cisplatin (CDDP) treatm...

journal_title：Oncology research

authors： Mansouri A,Zhang Q,Ridgway LD,Tian L,Claret FX

更新日期：2003-01-01 00:00:00

abstract：:We investigated the susceptibility of three inbred strains of rats to the hepatocarcinogen, N-nitrosomorpholine (NNM), to establish a spontaneous metastatic model of hepatocellular carcinoma (HCC). WS/Shi. SD/gShi, and F344/DuCrj rats were given 0.02% NNM in drinking water for 8 weeks and thereafter left without any t...

journal_title：Oncology research

authors： Murai T,Mori S,Hosono M,Iwakura Y,Takashima A,Oohara T,Makino S,Takeda R,Fukushima S

更新日期：2000-01-01 00:00:00

abstract：:N-Butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), which induces bladder carcinoma in female Wistar rats and female C3H/HeJ mice, was given as 0.025% (w/v) solution to rats and 0.05% to mice in the drinking water. Thymosin fraction 5 (TF5) or thymosin alpha 1 (T alpha 1) dissolved in normal saline, and normal saline (contr...

journal_title：Oncology research

authors： Wada S,Kinoshita Y,Kamizuru M,Asai Y,Iwata H,Ikemoto S,Hato F,Kishimoto T,Fukushima S

更新日期：1996-01-01 00:00:00

abstract：:It has been demonstrated that microRNAs (miRNAs) act as oncogenes or tumor suppressors in a variety of cancers. Our previous work suggested that miR-10a/b functioned as a tumor suppressor in gastric cancer, and miR-10b was also reported to be significantly downregulated in advanced stage cervical cancer tissues. Howev...

journal_title：Oncology research

authors： Zou D,Zhou Q,Wang D,Guan L,Yuan L,Li S

更新日期：2016-01-01 00:00:00

abstract：:Ovarian cancer is the most lethal disease among gynecological malignancies. More effective therapy is required to counter high recurrence rates and chemotherapy resistance. We investigated the efficacy and molecular mechanisms of three combined treatments (TCTs)-a novel histone deacetylase (HDAC) inhibitor OBP-801/YM7...

journal_title：Oncology research

authors： Akiyama M,Sowa Y,Taniguchi T,Watanabe M,Yogosawa S,Kitawaki J,Sakai T

更新日期：2017-09-21 00:00:00