Efficacy and Safety of Drug-Eluting Beads Transarterial Chemoembolization by CalliSpheres® in 275 Hepatocellular Carcinoma Patients: Results From the Chinese CalliSpheres® Transarterial Chemoembolization in Liver Cancer (CTILC) Study.

Abstract:

:The purpose of this study was to investigate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) treatment in Chinese hepatocellular carcinoma (HCC) patients and the prognostic factors for treatment response as well as survival. A total of 275 HCC patients were included in this prospective study. Treatment response was assessed by modified Response Evaluation Criteria in Solid Tumors (mRECIST), and progression-free survival (PFS) as well as overall survival (OS) were determined. Liver function and adverse events (AEs) were assessed before and after DEB-TACE operation. Complete response (CR), partial response (PR), and objective response rate (ORR) were 22.9%, 60.7%, and 83.6%, respectively. The mean PFS was 362 (95% CI: 34.9-375) days, the 6-month PFS rate was 89.4 ± 2.1%, while the mean OS was 380 (95% CI: 370-389) days, and the 6-month OS rate was 94.4 ± 1.7%. Multivariate logistic regression revealed that portal vein invasion (p = 0.011) was an independent predictor of worse clinical response. Portal vein invasion (p = 0.040), previous cTACE treatment (p = 0.030), as well as abnormal serum creatinine level (BCr) (p = 0.017) were independent factors that predicted worse ORR. In terms of survival, higher Barcelona Clinic Liver Cancer (BCLC) stage (p = 0.029) predicted for worse PFS, and abnormal albumin (ALB) (p = 0.011) and total serum bilirubin (TBIL) (p = 0.009) predicted for worse OS. The number of patients with abnormal albumin, total protein (TP), TBIL, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were augmented at 1 week posttreatment and were similar at 1-3 months compared with baseline. The most common AEs were pain, fever, nausea, and vomiting, and no severe AEs were observed in this study. DEB-TACE was effective and tolerable in treating Chinese HCC patients, and portal vein invasion, previous cTACE treatment, abnormal BCr, ALB, and TBIL appear to be important factors that predict worse clinical outcome.

journal_name

Oncol Res

journal_title

Oncology research

authors

Sun J,Zhou G,Xie X,Gu W,Huang J,Zhu D,Hu W,Hou Q,Shi C,Li T,Zhang X,Ji W,Ying S,Peng Z,Zhou J,Yu Z,Ji J,Du H,Guo X,Fang J,Han J,Xu H,Sun Z,Yu W,Shao G,Wu X,Hu H,Li L,Zheng J,Luo J,Chen Y,Cao

doi

10.3727/096504019X15662966719585

subject

Has Abstract

pub_date

2020-02-07 00:00:00

pages

75-94

issue

1

eissn

0965-0407

issn

1555-3906

journal_volume

28

pub_type

临床试验,杂志文章,多中心研究
  • Characterization of a novel immunocytolytic factor secreted by pancreatic adenocarcinoma.

    abstract::We observed a putative immunocytolytic factor secreted in the supernatant of several pancreatic adenocarcinoma cell lines that induces apoptosis in lymphocytes. A marked reduction in the viability of the target splenocytes was evident after coincubation with the supernatants from various pancreatic adenocarcinoma cell...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Divino CM,Angel LP,Brower ST,Chen SH

    更新日期:1999-01-01 00:00:00

  • Experimental study on safety for granulopoiesis in simultaneous therapy with recombinant human granulocyte colony-stimulating factor and chemotherapy.

    abstract::Since recombinant human granulocyte colony-stimulating factor (rhG-CSF) recruits hematopoietic progenitor cells into the cell cycle, the possibility remains that simultaneous injection of rhG-CSF and chemotherapeutic agents may aggravate the chemotherapy-induced neutropenia by sensitizing normal progenitor cells to th...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Kabaya K,Obuchi M,Watanabe M,Kusaka M,Seki M

    更新日期:1995-01-01 00:00:00

  • MicroRNA-204 Potentiates the Sensitivity of Acute Myeloid Leukemia Cells to Arsenic Trioxide.

    abstract::Although arsenic trioxide (ATO) is a well-known antileukemic drug used for acute promyelocytic leukemia treatment, the development of ATO resistance is still a big challenge. We previously reported that microRNA-204 (miR-204) was involved in the regulation of acute myeloid leukemia (AML) cell apoptosis, but its role i...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504019X15528367532612

    authors: Wang Z,Fang Z,Lu R,Zhao H,Gong T,Liu D,Hong L,Ma J,Zhang M

    更新日期:2019-09-23 00:00:00

  • MicroRNA-384 Inhibits the Growth and Invasion of Renal Cell Carcinoma Cells by Targeting Astrocyte Elevated Gene 1.

    abstract::MicroRNAs (miRNAs) are emerging as pivotal regulators in the development and progression of various cancers, including renal cell carcinoma (RCC). MicroRNA-384 (miR-384) has been found to be an important cancer-related miRNA in several types of cancers. However, the role of miR-384 in RCC remains unclear. In this stud...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X15035025554553

    authors: Song H,Rao Y,Zhang G,Kong X

    更新日期:2018-04-10 00:00:00

  • Flavonoids as inhibitors of MRP1-like efflux activity in human erythrocytes. A structure-activity relationship study.

    abstract::The potency of flavonoids (isoflavones, flavones, and flavanones) to inhibit efflux of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein (BCPCF) from human erythrocytes was investigated. Structure-activity relationship analysis showed that the strongest inhibitors were found among flavanones bearing a hydrophobic pren...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/000000003108747983

    authors: Bobrowska-Hägerstrand M,Wróbel A,Mrówczyńska L,Söderström T,Shirataki Y,Motohashi N,Molnár J,Michalak K,Hägerstrand H

    更新日期:2003-01-01 00:00:00

  • Targeted Silencing of Kim-1 Inhibits the Growth of Clear Cell Renal Cell Carcinoma Cell Line 786-0 In Vitro and In Vivo.

    abstract::To investigate the effect of Kim-1 on 786-0 cells in vivo and in vitro, several experiments such as quantitative real-time PCR, Western blot, MTT, colony formation, and flow cytometry were performed to evaluate the biological behavior of 786-0 cells treated with Kim-1 siRNA. Furthermore, the tumor xenograft model was ...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X15140544654946

    authors: Xu J,Sun L,Sun W,Tian J,Guo H

    更新日期:2018-08-23 00:00:00

  • Knockdown of Tripartite Motif-Containing Protein 37 (TRIM37) Inhibits the Proliferation and Tumorigenesis in Colorectal Cancer Cells.

    abstract::Tripartite motif-containing protein 37 (TRIM37), a new member of the RING-B-box-coiled-coil (RBCC) subfamily of zinc finger proteins, was found to be involved in the development and progression of several cancers. However, the expression pattern and biological functions of TRIM37 in colorectal cancer (CRC) remain unkn...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504016X14732772150181

    authors: Zhao P,Guan HT,Dai ZJ,Ma YG,Liu XX,Wang XJ

    更新日期:2017-01-02 00:00:00

  • Decreased Expression of miR-138-5p by lncRNA H19 in Cervical Cancer Promotes Tumor Proliferation.

    abstract::MicroRNAs (miRNAs) play important roles in the carcinogenesis of cervical cancer. However, the expression and underlying mechanisms of miRNA in cervical cancer progression remain unclear. In the present study, our data showed that the expression of miR-138-5p was significantly downregulated in cervical cancer tissues,...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X15017209042610

    authors: Ou L,Wang D,Zhang H,Yu Q,Hua F

    更新日期:2018-04-10 00:00:00

  • Enhanced PPAR-gamma expression may correlate with the development of Barrett's esophagus and esophageal adenocarcinoma.

    abstract::PPAR-gamma is known to have a growth-suppressive effect in different cancers. In this study, we investigated the role of PPAR-gamma in the development of Barrett's esophagus (BE) and esophageal adenocarcinoma (EA). We used immunohistochemistry and real-time PCR to analyze differences in PPAR-gamma protein and mRNA exp...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504011x12935427587849

    authors: Wang W,Wang R,Zhang Z,Li D,Yut Y

    更新日期:2011-01-01 00:00:00

  • miR-767-3p Inhibits Growth and Migration of Lung Adenocarcinoma Cells by Regulating CLDN18.

    abstract::Claudin18 (CLDN18) is necessary for intercellular junctions and is reported to be involved in cell migration and metastasis, making it like an oncogene in various cancer types. However, the biological function and regulatory mechanisms of CLDN18 in lung adenocarcinoma are not yet clear. In this study, we found downreg...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X15112639918174

    authors: Wan YL,Dai HJ,Liu W,Ma HT

    更新日期:2018-05-07 00:00:00

  • Combinatorial effects of monoclonal anti-p120 antibody (MAbp120), liposomes and hyperthermia on MCF-7 and LOX tumor cell lines.

    abstract::The human nucleolar protein p120 is highly expressed in human cancers. Its high expression in breast cancer correlates with a poor prognosis, and its overexpression in 3T3 mouse fibroblasts causes malignant transformation. This study reports that a combination of monoclonal anti-p 120 antibody (MAbp120), liposomes (Li...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Perlaky L,Busch RK,Busch H

    更新日期:1996-01-01 00:00:00

  • Expression patterns of aurora kinase B, heat shock protein 47, and periostin in esophageal squamous cell carcinoma.

    abstract::To elucidate the proteins related to the development and progress of esophageal squamous cell carcinoma (ESCC), we performed gene expression profile analysis of 14 ESCC tissues. We identified 182 genes that were commonly upregulated (p < 10(-5)) and 54 genes that were downregulated in ESCC tissues (p < 10(-6)). In ord...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504009790217407

    authors: Kwon YJ,Lee SJ,Koh JS,Kim SH,Kim YJ,Park JH

    更新日期:2009-01-01 00:00:00

  • Mutational alterations of the p16CDKN2A tumor suppressor gene have low incidence in mesenchymal chondrosarcoma.

    abstract::Mutational inactivation of the cyclin-dependent kinase inhibitors (CDKIs) (p16INK4A/MTS1) tumor suppressor gene has been found in a variety of human tumor types. To investigate the involvement of CDKI abnormality in mesenchymal chondrosarcoma, alterations of CDKIs were examined in human mesenchymal chondrosarcoma tiss...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/000000001108747381

    authors: Bae DK,Park YK,Chi SG,Lee CW,Unni KK

    更新日期:2000-01-01 00:00:00

  • DT-diaphorase: possible roles in cancer chemotherapy and carcinogenesis.

    abstract::DT-diaphorase [also called NAD(P)H:menadione oxidoreductase; NAD(P)H:(quinone acceptor) oxidoreductase; quinone reductase, azo-dye reductase] (EC.1.6.99.2) has been shown to have a role in activation of quinone-containing cancer chemotherapeutic prodrugs to their active form, as well as inactivation of a variety of xe...

    journal_title:Oncology research

    pub_type: 杂志文章,评审

    doi:

    authors: Rauth AM,Goldberg Z,Misra V

    更新日期:1997-01-01 00:00:00

  • Ursolic Acid Attenuates TGF-β1-Induced Epithelial-Mesenchymal Transition in NSCLC by Targeting Integrin αVβ5/MMPs Signaling.

    abstract::Transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) of non-small cell lung cancer (NSCLC) may contribute to tumor metastasis. TGF-β1-induced EMT in H1975 cells (a human NSCLC cell line) resulted in the adoption of mesenchymal responses that were predominantly mediated via the TGF-β1-...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X15051723858706

    authors: Ruan JS,Zhou H,Yang L,Wang L,Jiang ZS,Sun H,Wang SM

    更新日期:2019-05-07 00:00:00

  • Heterogeneous expression of DNA topoisomerase II alpha isoforms in tumor cell lines.

    abstract::DNA topoisomerase II alpha is a nuclear enzyme essential for DNA metabolism and cell cycle progression. Previous studies have shown that human tumor cell lines can express more than one topoisomerase II alpha isoform through alternative splicing. A 160-kDa isoform of topoisomerase II alpha has been described in severa...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Mo YY,Beck WT

    更新日期:1997-01-01 00:00:00

  • MicroRNA-107 Promotes Proliferation, Migration, and Invasion of Osteosarcoma Cells by Targeting Tropomyosin 1.

    abstract::Osteosarcoma is the most common primary bone malignancy manifested predominantly in children and young adults. Studies indicate that miR-107 is involved in the pathogenesis of osteosarcoma and that tropomyosin 1 (TPM1) acts as a tumor suppressor in many types of cancer. In this study, we analyzed the effect of miR-107...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X14882829077237

    authors: Jiang R,Zhang C,Liu G,Gu R,Wu H

    更新日期:2017-09-21 00:00:00

  • MicroRNA-744 Inhibits Cellular Proliferation and Invasion of Colorectal Cancer by Directly Targeting Oncogene Notch1.

    abstract::Accumulated studies have strongly implicated aberrantly expressed microRNAs (miRNAs) in carcinogenesis and cancer progression of various cancers, including colorectal cancer (CRC). Hence, a comprehensive study of miRNAs and their association with CRC may be a promising therapeutic method for patients with this maligna...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504018X15188747585738

    authors: Shen J,Li M

    更新日期:2018-10-17 00:00:00

  • Overexpression of NDRG2 Increases Iodine Uptake and Inhibits Thyroid Carcinoma Cell Growth In Situ and In Vivo.

    abstract::Medullary thyroid carcinoma (MTC) is an uncommon and highly aggressive tumor of the neuroendocrine system, which derives from the neuroendocrine C cells of the thyroid gland. Except for surgical resection, there are not very many effective systemic treatment options for MTC. N-Myc downstream-regulated gene 2 (NDRG2) h...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504015X14452563486093

    authors: Yin A,Wang C,Sun J,Gao J,Tao L,Du X,Zhao H,Yang J,Li Y

    更新日期:2016-01-01 00:00:00

  • Characterization of selective induction and alteration of xenobiotic biotransforming enzymes by vanadium during diethylnitrosamine-induced chemical rat liver carcinogenesis.

    abstract::Our recent studies have shown that vanadium, a dietary micronutrient, has an inhibitory response against experimentally induced rat liver carcinogenesis. In the present study, the effect of vanadium on hepatic xenobiotic biotransformation in rats exposed to diethylnitrosamine (DENA, 200 mg/kg, IP) was investigated to ...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Bishayee A,Roy S,Chatterjee M

    更新日期:1999-01-01 00:00:00

  • CRISPR/Cas9-Mediated Gene Knockout of ARID1A Promotes Primary Progesterone Resistance by Downregulating Progesterone Receptor B in Endometrial Cancer Cells.

    abstract::Medroxyprogesterone (MPA) is used for the conservative treatment of endometrial cancer. Unfortunately, progesterone resistance seriously affects its therapeutic effect. The purpose of the current study was to investigate the influence of deletion of AT-rich interactive domain 1A (ARID1A) in progesterone resistance in ...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504019X15561873320465

    authors: Wang H,Tang Z,Li T,Liu M,Li Y,Xing B

    更新日期:2019-09-23 00:00:00

  • miR-133a-3p Targets SUMO-Specific Protease 1 to Inhibit Cell Proliferation and Cell Cycle Progress in Colorectal Cancer.

    abstract::Dysregulation of SUMO-specific protease 1 (SENP1) expression has been reported in several kinds of cancer, including human colorectal and prostate cancers, proposing SENP1 as an oncogene with a critical role in cancer progression. miR-133a-3p has been reported as a tumor suppressor in several malignant neoplasias. How...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X15004613574679

    authors: Zhou GQ,Han F,Shi ZL,Yu L,Li XF,Yu C,Shen CL,Wan DW,Zhu XG,Li R,He SB

    更新日期:2018-06-11 00:00:00

  • Frequent mutations in the beta-catenin gene in desmoid tumors from patients without familial adenomatous polyposis.

    abstract::Mutations in the APC gene contribute to development of sporadic desmoid tumors as well as to the hereditary tumors that usually accompany familial adenomatous polyposis (FAP). Adenomatous polyposis coli (APC) mutations cause an intracellular accumulation of beta-catenin that results in abnormal signaling in the wnt/wi...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Miyoshi Y,Iwao K,Nawa G,Yoshikawa H,Ochi T,Nakamura Y

    更新日期:1998-01-01 00:00:00

  • WITHDRAWN: Downregulation of MicroRNA-152 and Inhibition of Cell Proliferation, Migration, and Invasion in Breast Cancer.

    abstract::Ahead of Print article withdrawn by publisher. ...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504017X14974821032421

    authors: Maimaitiming A,Wusiman A,Aimudula A,Tudahong T,Aisimutula D

    更新日期:2017-06-15 00:00:00

  • The identification of miR-375 as a potential biomarker in distal gastric adenocarcinoma.

    abstract::MicroRNAs (miRNAs) are endogenous small noncoding RNAs that negatively regulate gene expression at the posttranscriptional level and play an important role in carcinogenesis. Herein, we characterized the global expression of miRNA in distal gastric adenocarcinomas and determined if circulating miRNAs could be used as ...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504012x13522227232156

    authors: Zhang WH,Gui JH,Wang CZ,Chang Q,Xu SP,Cai CH,Li YN,Tian YP,Yan L,Wu B

    更新日期:2012-01-01 00:00:00

  • Transferrin and insulin enhance human colon tumor cell growth by differentiation class specific mechanisms.

    abstract::Human colon tumor cell lines that were adapted to grow in chemically defined medium were tested for their growth sensitivity to exogenous transferrin, insulin, and epidermal growth factor (EGF). Less differentiated cell lines, C and HCT116, were able to grow in the presence of a single peptide supplement, to respond s...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Yeoman LC,Wan CW,Zorbas MA

    更新日期:1996-01-01 00:00:00

  • HL-60 cells isolated for resistance to vincristine are defective in 12-O-tetradecanoylphorbol-13-acetate induced differentiation and the formation of a functional AP-1 complex.

    abstract::HL-60 cells isolated for resistance to vincristine are multidrug resistant and defective in the cellular accumulation of drug. Further studies demonstrate that these cells are also highly defective in 12-O-tetradecanoylphorbol-13-acetate (TPA) induced differentiation to macrophages. Analysis of this system demonstrate...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:

    authors: Ma L,Krishnamachary N,Perbal B,Center MS

    更新日期:1992-01-01 00:00:00

  • Association of interleukin-18 gene promoter polymorphism on the risk of cervix carcinogenesis in north Indian population.

    abstract::Cervical cancer is one of the most common neoplastic diseases affecting women, with a combined worldwide incidence of almost half a million new cases. Considering the fact that IL-18 plays an important role in the interactions among T cells, NK cells, and macrophages and induces IFN-gamma production, efforts should be...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/096504008785114156

    authors: Sobti RC,Shekari M,Tamandani DM,Malekzadeh K,Suri V

    更新日期:2008-01-01 00:00:00

  • The development of awareness of the carcinogenic hazard of inhaled iron.

    abstract::Numerous studies have observed that workers in ferriferous industries have an elevated risk of respiratory tract neoplasia. Research at the cellular and animal model levels indicates that iron compounds, per se, are carcinogenic. However, some investigators have suggested that inhaled iron compounds are merely carrier...

    journal_title:Oncology research

    pub_type: 杂志文章,评审

    doi:

    authors: Weinberg ED

    更新日期:1999-01-01 00:00:00

  • secErbB4-26/549 antagonizes ligand-induced ErbB4 tyrosine phosphorylation.

    abstract::ErbB4 is a member of the ErbB family of receptor tyrosine kinases. Because of a paucity of appropriate pharmacologic tools, little is known about ErbB4 functions in vivo. In response to this need, we hypothesized that a recombinant form of the extracellular domain of ErbB4 would antagonize ligand-induced receptor tyro...

    journal_title:Oncology research

    pub_type: 杂志文章

    doi:10.3727/0965040042707907

    authors: Gilmore JL,Riese DJ 2nd

    更新日期:2004-01-01 00:00:00