A study of antitumor effects of thymosin on rat and mouse urinary bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine.

abstract：:Laryngeal cancer, one of the most common head and neck malignancies, is an aggressive neoplasm. Increasing evidence has demonstrated that microRNAs (miRNAs) exert important roles in oncogenesis and progression of diverse types of human cancers. miR-632, a tumor-related miRNA, has been reported to be dysregulated and i...

journal_title：Oncology research

authors： Zhou ZX,Zhang ZP,Tao ZZ,Tan TZ

更新日期：2020-02-07 00:00:00

abstract：:We investigated the susceptibility of three inbred strains of rats to the hepatocarcinogen, N-nitrosomorpholine (NNM), to establish a spontaneous metastatic model of hepatocellular carcinoma (HCC). WS/Shi. SD/gShi, and F344/DuCrj rats were given 0.02% NNM in drinking water for 8 weeks and thereafter left without any t...

journal_title：Oncology research

authors： Murai T,Mori S,Hosono M,Iwakura Y,Takashima A,Oohara T,Makino S,Takeda R,Fukushima S

更新日期：2000-01-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is an uncommon and highly aggressive tumor of the neuroendocrine system, which derives from the neuroendocrine C cells of the thyroid gland. Except for surgical resection, there are not very many effective systemic treatment options for MTC. N-Myc downstream-regulated gene 2 (NDRG2) h...

journal_title：Oncology research

authors： Yin A,Wang C,Sun J,Gao J,Tao L,Du X,Zhao H,Yang J,Li Y

更新日期：2016-01-21 00:00:00

abstract：:Aberrantly expressed microRNAs (miRNAs/miRs) and their role in cancer development have recently gained more attention. However, the potential role of miRNAs in hepatocellular carcinoma (HCC) remains largely unknown. In this study, we demonstrated that miR-377 was markedly downregulated in HCC cell lines and primary hu...

journal_title：Oncology research

authors： Ge H,Zou D,Wang Y,Jiang H,Wang L

更新日期：2017-01-02 00:00:00

abstract：:A novel hydroquinone and NADH oxidase with protein disulfide-thiol interchange activity (designated ENOX2 or tNOX), associated exclusively with the outer leaflet of the plasma membrane at the surface of cancer cells and in sera of cancer patients, is absent from the surface of noncancer cells and from sera from health...

journal_title：Oncology research

authors： Tang X,Morré DJ,Morré DM

更新日期：2007-01-01 00:00:00

abstract：:3'-Azido-3'-deoxythymidine (AZT) competitively inhibited the transport of thymidine (Km = 0.23 mM) into human erythrocytes with a Ki of 1.0 mM at 37 degrees C. The principal human metabolite of AZT in plasma, the 5'-glucuronide (GAZT), was a weak inhibitor of the nucleoside transporter (< 20% inhibition of the influx ...

journal_title：Oncology research

authors： Zimmerman TP,Domin BA,Mahony WB

更新日期：1993-01-01 00:00:00

abstract：:It has been reported that upregulated SIRT1 (NAD(+)-dependent class III histone deacetylase) deacetylates the p53 protein, represses its function, and allows for tumor cell growth in various cancers. Here we investigated antitumor effects of tenovin-6, a small-molecule inhibitor of SIRT1 and SIRT2, in various colon ca...

journal_title：Oncology research

authors： Ueno T,Endo S,Saito R,Hirose M,Hirai S,Suzuki H,Yamato K,Hyodo I

更新日期：2013-01-01 00:00:00

abstract：:Human skin fibroblasts were exposed to global system for mobile communication (GSM) cellular phone radiofrequency for 1 h. GSM exposure induced alterations in cell morphology and increased the expression of mitogenic signal transduction genes (e.g., MAP kinase kinase 3, G2/mitotic-specific cyclin G1), cell growth inhi...

journal_title：Oncology research

authors： Pacini S,Ruggiero M,Sardi I,Aterini S,Gulisano F,Gulisano M

更新日期：2002-01-01 00:00:00

abstract：:Empty spiracles homeobox 2 (EMX2) is a homeodomain-containing transcription factor that plays an essential role in tumorigenesis. However, to the best of our knowledge, the role of EMX2 in human colorectal cancer (CRC) is still unclear. Thus, the aim of this study was to investigate the expression and role of EMX2 in ...

journal_title：Oncology research

authors： Zhang Y,Cao G,Yuan QG,Li JH,Yang WB

更新日期：2017-04-14 00:00:00

abstract：:This study was designed to investigate the role of miR-183 in modulating cell growth and apoptosis of tongue squamous cell carcinoma SCC25 cell line. Human squamous epithelial cell and squamous cell carcinoma cell line SCC25 was used, and miR-183 was inhibited. Cell growth, colony formation, and apoptotic rate, as wel...

journal_title：Oncology research

authors： Yan D,Cai X,Feng Y

更新日期：2016-10-27 00:00:00

abstract：:MicroRNAs (miRNAs) are emerging as pivotal regulators in the development and progression of various cancers, including renal cell carcinoma (RCC). MicroRNA-384 (miR-384) has been found to be an important cancer-related miRNA in several types of cancers. However, the role of miR-384 in RCC remains unclear. In this stud...

journal_title：Oncology research

authors： Song H,Rao Y,Zhang G,Kong X

更新日期：2018-04-10 00:00:00

abstract：:Metaplastic tubular complexes (MTC) have been proposed as precursor lesions for pancreatic adenocarcinoma (PDAC). In this study, we investigated the potential role of bone marrow-derived progenitor cells (BMPC) in the formation of MTC and PDAC in a rat model. F344 rats defective for CD26 (dipeptidyl peptidase IV, DPPI...

journal_title：Oncology research

authors： Pan JJ,Oh SH,Lee WC,Petersen BE

更新日期：2009-01-01 00:00:00

abstract：:Our recent studies have shown that vanadium, a dietary micronutrient, has an inhibitory response against experimentally induced rat liver carcinogenesis. In the present study, the effect of vanadium on hepatic xenobiotic biotransformation in rats exposed to diethylnitrosamine (DENA, 200 mg/kg, IP) was investigated to ...

journal_title：Oncology research

authors： Bishayee A,Roy S,Chatterjee M

更新日期：1999-01-01 00:00:00

abstract：:To ascertain whether insulin-like growth factors (IGF-1 and IGF-2) affect the estrogen- and insulin-responsive R3230AC mammary carcinoma, studies of IGF-1 and IGF-2 receptors were conducted on primary-culture tumor cells and on membranes purified from whole tumors. By saturation binding analysis, cells in culture disp...

journal_title：Oncology research

authors： Korc-Grodzicki B,Furlanetto RW,Hilf R

更新日期：1992-01-01 00:00:00

abstract：:This study evaluated the survival effects of metronomic maintenance therapy with oral fluoropyrimidine in patients with stage III colorectal cancer (CRC) according to epidermal growth factor receptor (EGFR) expression. We enrolled 197 patients with stage III CRC who had undergone radical resection and FOLFOX regimen a...

journal_title：Oncology research

authors： Huang CW,Ma CJ,Su WC,Chen YT,Tsai HL,Yeh YS,Chang TK,Hsu WH,Yu FJ,Wang JY

更新日期：2020-08-28 00:00:00

abstract：:Pancreatic cancer (PC) is a devastating malignant disease with a poor prognosis. This study aimed to investigate the role of urothelial carcinoma associated 1 (UCA1) in the progression of PC. Our results revealed that long noncoding RNA (lncRNA) UCA1 was overexpressed in PC tissues compared with adjacent histologicall...

journal_title：Oncology research

authors： Zhang X,Gao F,Zhou L,Wang H,Shi G,Tan X

更新日期：2017-11-02 00:00:00

abstract：:PPAR-gamma is known to have a growth-suppressive effect in different cancers. In this study, we investigated the role of PPAR-gamma in the development of Barrett's esophagus (BE) and esophageal adenocarcinoma (EA). We used immunohistochemistry and real-time PCR to analyze differences in PPAR-gamma protein and mRNA exp...

journal_title：Oncology research

authors： Wang W,Wang R,Zhang Z,Li D,Yut Y

更新日期：2011-01-01 00:00:00

abstract：: THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHER IN NOVEMBER 2020. ...

journal_title：Oncology research

authors： Yongyu Z,Lewei Y,Jian L,Yuqin S

更新日期：2018-10-17 00:00:00

abstract：:The aim of this study was to assess serum levels of vascular endothelial growth factor C and D (VEGF-C, VEGF-D) and soluble VEGF receptor 2 (sVEGFR-2) in patients with lung cancer during chemotherapy. The study included 80 patients (64 men and 16 women; mean age 61.1) diagnosed histologically with lung cancer. Forty-f...

journal_title：Oncology research

authors： Naumnik W,Izycki T,Swidzińska E,Ossolińiska M,Chyczewska E

更新日期：2007-01-01 00:00:00

abstract：:S100 binding protein A16 (S100A16) expression levels are closely associated with microRNA (miRNA) processing. Higher levels of S100A16 are reported during the progression of many cancers. Our study mainly explored the interaction between S100A16 and miR-6884-5p in gastric cancer (GC). Quantitative real-time polymerase...

journal_title：Oncology research

authors： Lv H,Hou H,Lei H,Nie C,Chen B,Bie L,Han L,Chen X

更新日期：2020-05-29 00:00:00

abstract：:Concentrations of the flame retardant 2,2',4,4'-tetrabrominated diphenyl ether (2,2',4,4'-TeBDE) in the adipose tissue of 77 individuals from Sweden were determined. The subjects were recruited during the time period 1995-97 and encompassed both men and women ranging from 28 to 85 years in age. Of the subjects include...

journal_title：Oncology research

authors： Hardell L,Lindström G,van Bavel B,Wingfors H,Sundelin E,Liljegren G

更新日期：1998-01-01 00:00:00

abstract：:The mechanism of action of the anthraquinone antileukemic drug mitoxantrone (MIT) was investigated and compared with that of daunorubicin (DNR) with emphasis on the interaction with DNA to clarify the more potent cytotoxic activity of MIT than DNR in human leukemia cells. MIT showed similar characteristics to those of...

journal_title：Oncology research

authors： Fukushima T,Kawai Y,Nakayama T,Yamauchi T,Yoshida A,Urasaki Y,Imamura S,Kamiya K,Tsutani H,Ueda T,Nakamura T

更新日期：1996-01-01 00:00:00

abstract：:Signal peptide CUB EGF-like domain-containing protein 2 (SCUBE2), a member of the SCUBE family of proteins, was recently found to play an important role in cancer development. However, little is known regarding its biological function in glioma. In the present study, we investigated the effect of SCUBE2 on glioma and ...

journal_title：Oncology research

authors： Guo E,Liu H,Liu X

更新日期：2017-03-13 00:00:00

abstract：:Thymosin-beta-4 (TB4) as an actin-sequestering peptide has been detected outside of cells in blood plasma or in wound fluid. TB4 induces tumor metastasis and paclitaxel resistance, which is the most significant obstacle to successful therapy in tumors. Here we investigated the inhibitory effect of TB4 peptides on tumo...

journal_title：Oncology research

authors： Moon EY,Song JH,Yang KH

更新日期：2007-01-01 00:00:00

abstract：:Colorectal cancer is an aggressive malignancy for which there are limited treatment options. Oncolytic vaccinia virus isbeing developed as a novel strategy for cancer therapy. Arming vaccinia virus with immunostimulatory cytokines can enhance the tumor cell-specific replication and antitumor efficacy. Interleukin-24 (...

journal_title：Oncology research

authors： Deng L,Yang X,Fan J,Ding Y,Peng Y,Xu D,Huang B,Hu Z

更新日期：2020-07-08 00:00:00

abstract：:Drug resistance is the major obstacle for the successful therapy of lung adenocarcinoma. It was suggested that ß-elemene, a major isoform of elemene, could reverse the drug resistance in lung cancer cells. However, the underlying mechanisms remains poorly known. Here, we aimed to investigate whether elemene is involve...

journal_title：Oncology research

authors： Zhou K,Wang L,Cheng R,Liu X,Mao S,Yan Y

更新日期：2017-05-23 00:00:00

abstract：:Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the initiation and development of many solid tumors, including osteosarcoma (OS). In this study, we showed that MALAT1 was increased in human OS tissues and cell lines. MALAT1 knockdown suppressed OS ce...

journal_title：Oncology research

authors： Zhang Y,Dai Q,Zeng F,Liu H

更新日期：2018-04-27 00:00:00

abstract：:Point mutations and deletions in the p53 tumor suppressor gene occur frequently in advanced stage bladder tumors. To extend these observations to an in vitro model of bladder tumorigenicity, we have evaluated the presence of p53 mutations in a panel of bladder carcinoma cell lines. p53 alleles were cloned using the re...

journal_title：Oncology research

authors： Cooper MJ,Haluschak JJ,Johnson D,Schwartz S,Morrison LJ,Lippa M,Hatzivassiliou G,Tan J

更新日期：1994-01-01 00:00:00

abstract：:Spinal osteosarcoma (OS) is a malignant tumor that has a poor outcome. MicroRNA-520b (miR-520b) acts as a cancer suppressor in various types of cancer. Because of the limited amount of literature on OS, we aimed to identify the role of miR-520b in OS. The miR-520b level in clinical spinal OS tissues and adjacent nontu...

journal_title：Oncology research

authors： Wang J,Pang W,Zuo Z,Zhang W,He W

更新日期：2017-09-21 00:00:00

abstract：:We investigated the regulatory effect of interleukin (IL) 10 on IL-12-inducible killer activity of blood mononuclear cells (MNC) of healthy subjects. IL-10 suppressed non-MHC-restricted killer activity induced by IL-12 in a dose-dependent manner. Cytotoxicity against Daudi cells of blood MNC activated with optimal dos...

journal_title：Oncology research

authors： Pai K,Yanagawa H,Takauchi E,Suzuki Y,Hanibuchi M,Parajuli P,Sone S

更新日期：1998-01-01 00:00:00