Overexpression of SCUBE2 Inhibits Proliferation, Migration, and Invasion in Glioma Cells.

abstract：:O6-Alkylguanine-DNA alkyltransferase (AGT) is a DNA repair protein that reverses alkylation damage produced by chloroethylnitrosoureas and is a major determinant of cellular resistance to adjuvant chemotherapy with these drugs. AGT activity was measured in 119 samples from 69 patients, including normal, tumor, and dis...

journal_title：Oncology research

authors： White A,Kibitel J,Garcia Y,Belanich M,Yarosh D,Wideroff J,Levin L,Held D,Fuchs A,Citron M

更新日期：1997-01-01 00:00:00

abstract：:There is growing evidence on the clinical significance of Tumor Microenvironment (TME) cells in predicting prognosis and therapeutic effects. However, cell interactionsin tumor microenvironments have not been thoroughly studied or systematicallyanalyzed so far. In this study, 22 immune cell components in the lung aden...

journal_title：Oncology research

authors： Ling B,Huang Z,Huang S,Qian L,Li G,Tang Q

更新日期：2020-05-29 00:00:00

abstract：:The aim of this study was to assess serum levels of vascular endothelial growth factor C and D (VEGF-C, VEGF-D) and soluble VEGF receptor 2 (sVEGFR-2) in patients with lung cancer during chemotherapy. The study included 80 patients (64 men and 16 women; mean age 61.1) diagnosed histologically with lung cancer. Forty-f...

journal_title：Oncology research

authors： Naumnik W,Izycki T,Swidzińska E,Ossolińiska M,Chyczewska E

更新日期：2007-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a disease with poor prognosis rates and ineffective therapeutic options. Previous studies have reported the involvement of mitogen-inducible gene 6 (MIG-6) as a negative regulator in tumor formation. MicroRNAs (miRNAs) play crucial roles in the development of different types of cancer...

journal_title：Oncology research

authors： Li H,Chen H,Wang H,Dong Y,Yin M,Zhang L,Wei J

更新日期：2018-05-07 00:00:00

abstract：:Protein disulfide isomerases A6 (PDIA6) belongs to the PDI family. Recently, PDIA6 was found to have a close association with various cancers. However, there has been little investigation into the biological functions of PDIA6 in bladder cancer (BC). In this study, we explored the expression pattern and functional sig...

journal_title：Oncology research

authors： Cheng HP,Liu Q,Li Y,Li XD,Zhu CY

更新日期：2017-04-14 00:00:00

abstract：:To investigate the effect of Kim-1 on 786-0 cells in vivo and in vitro, several experiments such as quantitative real-time PCR, Western blot, MTT, colony formation, and flow cytometry were performed to evaluate the biological behavior of 786-0 cells treated with Kim-1 siRNA. Furthermore, the tumor xenograft model was ...

journal_title：Oncology research

authors： Xu J,Sun L,Sun W,Tian J,Guo H

更新日期：2018-08-23 00:00:00

abstract：:Baicalein, a flavonoid derived from the root of Scutellaria baicalensis, has been reported to possess multiple pharmacological activities, such as anticancer and anti-inflammatory properties. This study investigated the effect of baicalein in cervical cancer cells. Cell growth curve and MTT assay were performed and re...

journal_title：Oncology research

authors： Wu X,Yang Z,Dang H,Peng H,Dai Z

更新日期：2018-05-07 00:00:00

abstract：:Previous studies demonstrated that an antisense phosphorothioate oligodeoxynucleotide, ISIS 3466, to the human nucleolar p120 protein, markedly inhibited the growth of human tumor cell lines in vitro and inhibited the growth of the human LOX tumor in vivo in an i.p./i.p. model, in the presence of DOTMA (Perlaky et al....

journal_title：Oncology research

authors： Saijo Y,Perlaky L,Valdez BC,Wang H,Henning D,Busch H

更新日期：1993-01-01 00:00:00

abstract：:A novel keto-diepoxide Sch 49209 and its derivative Sch 50672, produced by the fungus Nattrassia mangiferae, inhibited tumor cell invasion through an artificial basement membrane. These compounds, at nontoxic concentrations, inhibited invasion of HT-1080 cells in a dose-dependent manner. The IC50 values for Sch 49209 ...

journal_title：Oncology research

authors： King I,Blood C,Chu M,Patel M,Liu M,Li Z,Robertson N,Maxwell E,Catino JJ

更新日期：1995-01-01 00:00:00

abstract：:Astragaloside IV (AS-IV) is an active ingredient in Astragalus membranaceus and is involved in various biological processes, such as regulating the immune system, and counteracting inflammation and malignancy. The aim of this study was to explore the effect of AS-IV on non-small cell lung cancer (NSCLC) cells. Cell co...

journal_title：Oncology research

authors： Jia L,Lv D,Zhang S,Wang Z,Zhou B

更新日期：2019-03-29 00:00:00

abstract：:Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are used as first-line agents for treating nonsquamous cell lung cancer with EGFR mutation, there are many patients who have to receive these drugs following platinum-based chemotherapy. This study was designed to define whether exposure ...

journal_title：Oncology research

authors： Rho JK,Choi YJ,Choi YR,Kim SY,Choi SJ,Choi CM,Na II,Lee JC

更新日期：2011-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies, with a poor prognosis and high recurrence rate. In the present study, we identified CD133, one of the markers of cancer stem cells, as a novel molecular target of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). In four human HCC ce...

journal_title：Oncology research

authors： Lee SH,Hyun SK,Kim HB,Kang CD,Kim SH

更新日期：2016-10-27 00:00:00

abstract：:To elucidate the proteins related to the development and progress of esophageal squamous cell carcinoma (ESCC), we performed gene expression profile analysis of 14 ESCC tissues. We identified 182 genes that were commonly upregulated (p < 10(-5)) and 54 genes that were downregulated in ESCC tissues (p < 10(-6)). In ord...

journal_title：Oncology research

authors： Kwon YJ,Lee SJ,Koh JS,Kim SH,Kim YJ,Park JH

更新日期：2009-01-01 00:00:00

abstract：:The clinical study of compounds that modulate multidrug resistance has been hindered by both the toxicities of these agents and the inability to monitor their effectiveness at the level of the tumor cell. Previously, toremifene has been shown to be well tolerated clinically and to sensitize multidrug resistant cells t...

journal_title：Oncology research

authors： Baker WJ,Maenpaa JU,Wurz GT,Koester SK,Seymour RC,Emshoff VD,Wiebe VJ,DeGregorio MW

更新日期：1993-01-01 00:00:00

abstract：:Human skin fibroblasts were exposed to global system for mobile communication (GSM) cellular phone radiofrequency for 1 h. GSM exposure induced alterations in cell morphology and increased the expression of mitogenic signal transduction genes (e.g., MAP kinase kinase 3, G2/mitotic-specific cyclin G1), cell growth inhi...

journal_title：Oncology research

authors： Pacini S,Ruggiero M,Sardi I,Aterini S,Gulisano F,Gulisano M

更新日期：2002-01-01 00:00:00

abstract：:Inflammation plays a major role in the pathogenesis of cervical cancer. Chemokines are involved in inflammation, cancer, and infectious diseases. Therefore, we evaluated the association of the chemokine receptor gene polymorphism CCR5 Delta32 with risk of cervical cancer. A total of 150 histopathologically confirmed p...

journal_title：Oncology research

authors： Singh H,Sachan R,Jain M,Mittal B

更新日期：2008-01-01 00:00:00

abstract：:N-Butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), which induces bladder carcinoma in female Wistar rats and female C3H/HeJ mice, was given as 0.025% (w/v) solution to rats and 0.05% to mice in the drinking water. Thymosin fraction 5 (TF5) or thymosin alpha 1 (T alpha 1) dissolved in normal saline, and normal saline (contr...

journal_title：Oncology research

authors： Wada S,Kinoshita Y,Kamizuru M,Asai Y,Iwata H,Ikemoto S,Hato F,Kishimoto T,Fukushima S

更新日期：1996-01-01 00:00:00

abstract：:Human papillomavirus type 16 (HPV16) is a major causative factor in the development of uterine cervical carcinomas. We investigated the role of E6/E7 in tumor formation. Skin-specific E6/E7 transgenic mice showed approximately twice as many tumors compared with nontransgenic mice in dimethylbenz[a]anthracene (DMBA)-in...

journal_title：Oncology research

authors： Kim MO,Kim SH,Shin MJ,Yu DH,Kim BS,Chang KT,Lee S,Park YB,Lee TH,Ryoo ZY

更新日期：2007-01-01 00:00:00

abstract：:The present study aimed to investigate the effect of miR-186 on proliferation, migration, invasion, and epithelialmesenchymal transition (EMT) of hepatocellular carcinoma (HCC). In this work, miR-186 was downregulated in HCC tissues and cells, and low miR-186 level helped predict the occurrence of vascular invasion an...

journal_title：Oncology research

authors： Lu J,Zhao Z,Ma Y

更新日期：2020-12-10 00:00:00

abstract：:Ahead of Print article withdrawn by publisher. ...

journal_title：Oncology research

authors： Maimaitiming A,Wusiman A,Aimudula A,Tudahong T,Aisimutula D

更新日期：2017-06-15 00:00:00

abstract：:Osteosarcoma is the most common primary bone malignancy manifested predominantly in children and young adults. Studies indicate that miR-107 is involved in the pathogenesis of osteosarcoma and that tropomyosin 1 (TPM1) acts as a tumor suppressor in many types of cancer. In this study, we analyzed the effect of miR-107...

journal_title：Oncology research

authors： Jiang R,Zhang C,Liu G,Gu R,Wu H

更新日期：2017-09-21 00:00:00

abstract：:There is an urgent need to improve the clinical management of hepatocellular carcinoma (HCC), one of the most common causes of global cancer-related deaths. Zingibar officinale is a medicinal herb used throughout history for both culinary and medicinal purposes. It has antioxidant, anticarcinogenic, and free radical s...

journal_title：Oncology research

authors： Elkady AI,Abu-Zinadah OA,Hussein RAEH

更新日期：2017-07-05 00:00:00

abstract：:Electron-affinic compounds with strong DNA intercalating properties have demonstrated less than the expected radiosensitization due to restriction of their mobility along the DNA backbone and their lower extravascular diffusion in tumors. A 2-nitroimidazole linked 1,2,3,4-tetrahydroacridine derivative (THNLA-1) has be...

journal_title：Oncology research

authors： Papadopoulou MV,Rosenzweig HS,Doddi M,Bloomer WD

更新日期：1994-01-01 00:00:00

abstract：:Adaptive changes occurring in C1300 murine neuroblastoma cell lines developed for resistance to nucleoside analogue inhibitors of S-adenosyl-L-homocysteine hydrolase (AdoHcyase, EC 3.3.1.1) were investigated. Two drug-resistant cell lines, rMNB-MDL-7-2 and rMNB-Deaz-7-2, were established from wild-type C1300 neuroblas...

journal_title：Oncology research

authors： Hamre MR,Clark SH,Mirkin BL

更新日期：1995-01-01 00:00:00

abstract：:The importance of receptors involved in the clearance of proteases and protease/inhibitor complexes in tumor invasion is unknown. We studied the expression of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP/alpha 2-MR), the major receptor involved in the clearance of protease/i...

journal_title：Oncology research

authors： Kancha RK,Stearns ME,Hussain MM

更新日期：1994-01-01 00:00:00

abstract：:Kaempferol is a flavonoid that has been extensively investigated owing to its antitumor effects. Nevertheless, little is known about its underlying mechanisms of action. We aimed to explore the role of kaempferol in breast cancer (BC), and thus we investigated how kaempferol suppresses the growth of BC cells. The cell...

journal_title：Oncology research

authors： Zhu L,Xue L

更新日期：2019-06-21 00:00:00

abstract：:Medroxyprogesterone (MPA) is used for the conservative treatment of endometrial cancer. Unfortunately, progesterone resistance seriously affects its therapeutic effect. The purpose of the current study was to investigate the influence of deletion of AT-rich interactive domain 1A (ARID1A) in progesterone resistance in ...

journal_title：Oncology research

authors： Wang H,Tang Z,Li T,Liu M,Li Y,Xing B

更新日期：2019-09-23 00:00:00

abstract：:Ameloblastoma is the most frequently encountered odontogenic tumor, characterized by a locally invasive behavior, frequent recurrences, and, although rare, metastatic capacity. Loss or inactivation of tumor suppressor genes (TSGs) allows cells to acquire neoplastic growth. The ING family proteins are tumor suppressors...

journal_title：Oncology research

authors： Borkosky SS,Gunduz M,Beder L,Tsujigiwa H,Tamamura R,Gunduz E,Katase N,Rodriguez AP,Sasaki A,Nagai N,Nagatsuka H

更新日期：2010-01-01 00:00:00

abstract：:Empty spiracles homeobox 2 (EMX2) is a homeodomain-containing transcription factor that plays an essential role in tumorigenesis. However, to the best of our knowledge, the role of EMX2 in human colorectal cancer (CRC) is still unclear. Thus, the aim of this study was to investigate the expression and role of EMX2 in ...

journal_title：Oncology research

authors： Zhang Y,Cao G,Yuan QG,Li JH,Yang WB

更新日期：2017-04-14 00:00:00

abstract：:Carbonic anhydrase (CA) IX has emerged as a promising target for cancer therapy. It is highly upregulated in hypoxic regions and mediates pH regulation critical for tumor cell survival as well as extracellular acidification of the tumor microenvironment, which promotes tumor aggressiveness via various mechanisms, such...

journal_title：Oncology research

authors： Riemann A,Güttler A,Haupt V,Wichmann H,Reime S,Bache M,Vordermark D,Thews O

更新日期：2018-03-05 00:00:00