Abstract:
:The aim of this study was to assess serum levels of vascular endothelial growth factor C and D (VEGF-C, VEGF-D) and soluble VEGF receptor 2 (sVEGFR-2) in patients with lung cancer during chemotherapy. The study included 80 patients (64 men and 16 women; mean age 61.1) diagnosed histologically with lung cancer. Forty-four (55%) had non-small cell lung cancer (NSCLC) and 36 (45%) had small cell lung cancer (SCLC). Squamous cell carcinoma was established in 56% (25 patients) of all patients with NSCLC, adenocarcinoma in 20% (9 patients), and non-small cell lung cancer in 23% (10 patients). The control group consisted of 20 healthy volunteers. Peripheral blood samples were taken before and after four cycles of chemotherapy. VEGF-C, VEGF-D, and sVEGFR-2 levels were assessed by ELISA method. Serum levels of VEGF-C and VEGF-D were significantly higher in both NSCLC and SCLC groups in comparison with controls. VEGF-C concentration decreased after chemotherapy, whereas VEGF-D concentration was at the same level. No correlation was found between VEGF-C and VEGF-D concentrations and the effect of treatment. Patients with lung cancer and progression after chemotherapy (PD) had the higher concentration of sVEGFR-2 than patients with partial remission (PR). The levels of sVEGFR-2 were lower before and after treatment than in controls. No relation was found between VEGF-C, VEGF-D, and sVEGFR-2 concentrations and the histological type and staging of lung cancer. Summing up, serum concentrations of VEGF-C and VEGF-D were higher in patients with lung cancer both before and after chemotherapy than in healthy controls, whereas sVEGFR-2 concentration was lower than in healthy controls. An increase in concentration of sVEGFR-2 during chemotherapy may suggest progression of the disease. However, it requires further examination.
journal_name
Oncol Resjournal_title
Oncology researchauthors
Naumnik W,Izycki T,Swidzińska E,Ossolińiska M,Chyczewska Esubject
Has Abstractpub_date
2007-01-01 00:00:00pages
445-51issue
9eissn
0965-0407issn
1555-3906journal_volume
16pub_type
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journal_title:Oncology research
pub_type: 杂志文章,评审
doi:10.3727/096504010x12828372551867
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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doi:10.3727/096504017X14886494526344
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journal_title:Oncology research
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journal_title:Oncology research
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-01-01 00:00:00
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journal_title:Oncology research
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journal_title:Oncology research
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journal_title:Oncology research
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doi:10.3727/096504017X15051723858706
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journal_title:Oncology research
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journal_title:Oncology research
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doi:10.3727/096504012x13522227232156
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doi:10.3727/096504012x13285365944337
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journal_title:Oncology research
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